Periprosthetic infection: diagnostic and treatment. Part 1 (literature review)

Filipenko, Volodymyr; Marushchak, O. P.; Bondarenko, Stanislav

doi:10.15674/0030-598720162102-110

Cited by 2 publications

(2 citation statements)

References 44 publications

(41 reference statements)

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“…Предложены многочисленные клинические, клинико-лабораторные, визуализирующие, патоморфологические критерии идентификации ППИ. Из клинико-лабораторных методов наиболее широко изученными и используемыми в практике диагностики ППИ являются уровень СОЭ, С-реактивный белок, содержание нейтрофильных лейкоцитов в периферической крови и аспиратах перипротезной жидкости, а также количественные цитологические и интраоперационные гистологические исследования [17]. Было установлено, что гистологическое исследование замороженных срезов перипротезных тканей с подсчетом порогового количества нейтрофильных лейкоцитов обладает высокой чувствительностью при подтверждении ППИ, однако весьма умеренной специфичностью при ее исключении [18].…”

Section: Discussionunclassified

Morphometric Parameters of Lower Leg Tissues and Their Correlation with Laboratory Data in Patients with Post-Traumatic Osteomyelitis

Григоровский

Грицай

Цокало

et al. 2021

Traumatology and Orthopedics of Russia

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Background. Knowledge about the pathological processes in the tissues of the limb is necessary for the targeted optimization of their course, the expectation of certain treatment results. The aim of the study was to determine the ratio of different severity cases and the correlation between individual clinical, laboratory and morphometric indicators of the tissues state in patients with trophic disorders in the extremity.Materials and Methods.The material was fragments of the lower leg tissues (bones, soft tissues, skin) of 38 patients with chronic post-traumatic osteomyelitis. Gradation morphometric indicators reflecting the tissues state in the lesion focuses were used. Frequency analysis of semiquantitative indicators and correlation analysis of the relationships between clinical, laboratory and morphometric indicators with the evaluation of the association coefficient were carried out. Results.Trophic disorders in the limb tissues (bones, soft tissues, muscles, skin), observed in patients with lower leg bones post-traumatic osteomyelitis, do not represent a group of well-defined pathological processes. They form a complex of dyscirculatory, ischemic, necrotic, dystrophic, atrophic, inflammatory, reparative and regenerative changes, which are combined in tissues in different proportions. This involves the use of a number of quantitative and semi-quantitative, gradation indicators: clinical, laboratory, and pathomorphological. Pathomorphological changes in the lesions in patients with chronic posttraumatic osteomyelitis of the lower leg bones with clinical signs of trophic disorders do not differ qualitatively from the changes usually detected in chronic post-traumatic osteomyelitis. In the bones, the most frequent are destructive focuses with a predominance of exudative and productive inflammation of high activity, sequestration and osteonecrosis. In paraossal soft tissues, more common are focuses, in which mature fibrous tissue and productive inflammation of low activity predominate. In the skin near the chronic post-traumatic osteomyelitis focuses, there is dermis fibrosis and productive inflammation of low activity.Conclusion. A number of correlations between clinical and laboratory parameters, on the one hand, and morphological parameters, on the other, have been established. The closest and most stable connections for different sites are the following indicators: blood leukocytes (negative dependence for affected bone, soft tissue and skin tissues), ESR (positive dependence for soft tissues), C-reactive protein (positive dependence for soft tissues and skin), agglutination with a polyvalent strain of Staphylococcus aureus (negative dependence for affected bones and skin).

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Section: Discussionunclassified

Morphometric Parameters of Lower Leg Tissues and Their Correlation with Laboratory Data in Patients with Post-Traumatic Osteomyelitis

Григоровский

Грицай

Цокало

et al. 2021

Traumatology and Orthopedics of Russia

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“…Більшість праць останнього десятиліття, де аналізували діагностичні можливості клінічних методів оцінювання у хворих з інфекцією органів опорно-рухової системи, розглядають виявлення перипротезної інфекції після ендопротезування великих суглобів. Запропоновано численні клінічні, клініко-лабораторні, візуалізивні, морфологічні критерії ідентифікації перипротезної інфекції [12][13][14].…”

Section: продовження таблиціunclassified

Crural tissues histopathology and clinical-morphological correlations in patients with traumatic osteomyelitis, combined with trophic disorders

Hryhorovskyi¹,

Hrytsai²,

Цокало³

et al. 2020

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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Periprosthetic infection: diagnostic and treatment. Part 1 (literature review)

Cited by 2 publications

References 44 publications

Morphometric Parameters of Lower Leg Tissues and Their Correlation with Laboratory Data in Patients with Post-Traumatic Osteomyelitis

Morphometric Parameters of Lower Leg Tissues and Their Correlation with Laboratory Data in Patients with Post-Traumatic Osteomyelitis

Crural tissues histopathology and clinical-morphological correlations in patients with traumatic osteomyelitis, combined with trophic disorders

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