“…This is particularly pronounced in patients with severe AS and with longer duration of catheterization. 33,34 Intuitively, the larger caliber and stiffer catheters used in TAVI result in comparatively worse disruption and, therefore, increased embolic load. 35 Furthermore, repeated attempts to cross the often friable calcified valve, a higher degree of manipulation of the aortic valve annulus, longer procedural duration, and the forces of valve deployment and balloon pre/postdilation all potentially worsen this disruption.…”