Periprocedural effects of statins on the incidence of contrast-induced acute kidney injury: a systematic review and meta-analysis of randomized controlled trials

Cheungpasitporn, Wisit; Kittanamongkolchai, Wonngarm; Edmonds, Peter J.; O'Corragain, O.A.; Srivali, Narat; Ungprasert, Patompong; Erickson, Stephen B.

doi:10.3109/0886022x.2015.1010939

Cited by 18 publications

(10 citation statements)

References 38 publications

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“…Contrast media are universally classified as a nephrotoxic agent (35)(36)(37). However, patients who require contrast material for imaging studies or procedures usually carry a clinical milieu that predisposes them to a higher risk of developing AKI.…”

Section: Discussionmentioning

confidence: 99%

The effects of contrast media volume on acute kidney injury after transcatheter aortic valve replacement: a systematic review and meta‐analysis

Cheungpasitporn

Podboy

Gillaspie

et al. 2016

J Evidence Based Medicine

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Section: Discussionmentioning

confidence: 99%

The effects of contrast media volume on acute kidney injury after transcatheter aortic valve replacement: a systematic review and meta‐analysis

Cheungpasitporn

Podboy

Gillaspie

et al. 2016

J Evidence Based Medicine

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“…However, other reports have not demonstrated such association ( 32 , 34 , 40 - 43 ). Minimization of the contrast dose during TAVR to <100 mL and use of low or iso-osmolar contrast media can explain these observations ( 34 , 35 , 37 , 44 ).…”

Section: Contrast Agent Exposurementioning

confidence: 99%

Transcatheter aortic valve replacement; a kidney’s perspective

Cheungpasitporn¹,

Kashani²

2016

J Renal Inj Prev

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Transcatheter aortic valve replacement (TAVR) has now emerged as a viable treatment option for high-risk patients with severe aortic stenosis (AS) who are not suitable candidates for surgical aortic valve replacement (SAVR). Despite encouraging published outcomes, acute kidney injury (AKI) is common and lowers the survival of patients after TAVR. The pathogenesis of AKI after TAVR is multifactorial including TAVR specific factors such as the use of contrast agents, hypotension during rapid pacing, and embolization; preventive measures may include pre-procedural hydration, limitation of contrast dye exposure, and avoidance of intraprocedural hypotension. In recent years, the number of TAVR performed worldwide has been increasing, as well as published data on renal perspectives of TAVR including AKI, chronic kidney disease, end-stage kidney disease, and kidney transplantation. This review aims to present the current literature on the nephrology aspects of TAVR, ultimately to improve the patients’ quality of care and outcomes.

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“…Contrast-induced acute kidney injury (CIAKI), or contrast-induced nephropathy (CIN), is associated with a significant increase in mortality and morbidity in patients with native kidneys[ 1 - 7 ]. The incidence of CIAKI has been reported from 2% in the general population without risk factors, to more than 20% in high-risk patients[ 1 , 8 - 12 ].…”

Section: Introductionmentioning

confidence: 99%

Contrast-induced acute kidney injury in kidney transplant recipients: A systematic review and meta-analysis

Cheungpasitporn¹,

Thongprayoon²,

Mao³

et al. 2017

WJT

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AIMTo evaluate the incidence of contrast-induced acute kidney injury (CIAKI) in kidney transplant recipients.METHODSA literature search was performed using MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews from the inception of the databases through July 2016. Studies assessing the incidence of CIAKI in kidney transplant recipients were included. We applied a random-effects model to estimate the incidence of CIAKI.RESULTSSix studies of 431 kidney transplant recipients were included in the analyses to assess the incidence of CIAKI in kidney transplant recipients. The estimated incidence of CIAKI and CIAKI-requiring dialysis were 9.6% (95%CI: 4.5%-16.3%) and 0.4% (95%CI: 0.0%-1.2%), respectively. A sensitivity analysis limited only to the studies that used low-osmolar or iso-osmolar contrast showed the estimated incidence of CIAKI was 8.0% (95%CI: 3.5%-14.2%). The estimated incidences of CIAKI in recipients who received contrast media with cardiac catheterization, other types of angiogram, and CT scan were 16.1% (95%CI: 6.6%-28.4%), 10.1% (95%CI: 4.2%-18.0%), and 6.1% (95%CI: 1.8%-12.4%), respectively. No graft losses were reported within 30 d post-contrast media administration. However, data on the effects of CIAKI on long-term graft function were limited.CONCLUSIONThe estimated incidence of CIAKI in kidney transplant recipients is 9.6%. The risk stratification should be considered based on allograft function, indication, and type of procedure.

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Periprocedural effects of statins on the incidence of contrast-induced acute kidney injury: a systematic review and meta-analysis of randomized controlled trials

Abstract: Our study demonstrates a statistically significant protective effect of statin treatment during procedures with contrast exposures. This finding suggests the use of statins in addition to standard IV crystalloid hydration may be beneficial in the prevention of CIAKI.

Cited by 18 publications

References 38 publications

The effects of contrast media volume on acute kidney injury after transcatheter aortic valve replacement: a systematic review and meta‐analysis

The effects of contrast media volume on acute kidney injury after transcatheter aortic valve replacement: a systematic review and meta‐analysis

Transcatheter aortic valve replacement; a kidney’s perspective

Contrast-induced acute kidney injury in kidney transplant recipients: A systematic review and meta-analysis

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