Peripherally Inserted Central Catheters May Lower the Incidence of Catheter-Related Blood Stream Infections in Patients in Surgical Intensive Care Units

Gunst, Mark; Matsushima, Kazuhide; Vanek, Sue L.; Gunst, Richard F.; Shafi, Shahid; Frankel, Heidi L.

doi:10.1089/sur.2008.058

Cited by 89 publications

(89 citation statements)

References 27 publications

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“…All of the different pathogens responsible for the PICCrelated BSI, the exit-site infection, and the septic thrombophlebitis are listed in Table 4. Our lower infection rate could be due to the fact that very few ICU patients were included in comparison with Gunst's and Chopra's cohorts [7,13]. However, this was partially offset by high recruitment of oncologic (64 %) and onco-hematologic (46 %) patients whom are known to be at increased risk of infection because of immunosuppression [14,15].…”

Section: Microbiologymentioning

confidence: 93%

Peripherally Inserted Central Catheter-Related Infections in a Cohort of Hospitalized Adult Patients

Bouzad

Duron²,

Bousquet

et al. 2015

Cardiovasc Intervent Radiol

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Section: Microbiologymentioning

confidence: 93%

Peripherally Inserted Central Catheter-Related Infections in a Cohort of Hospitalized Adult Patients

Bouzad

Duron²,

Bousquet

et al. 2015

Cardiovasc Intervent Radiol

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“…Well-established interventions, such as promotion of hand hygiene, emphasis on sterile technique for line placement, and prompt removal of unneeded central venous lines and peripherally placed lines for long-term use all contribute to lower rates of infection by these organisms [7,10]. However, our findings are more indicative of a shift in the background flora of our institution.…”

Section: Discussionmentioning

confidence: 65%

Temporal Trends in Blood Stream Infection Isolates from Surgical Patients

Guidry

Rosenberger

Petroze

et al. 2015

Surgical Infections

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Background: Blood stream infections (BSIs) are a common source of morbidity and death in hospitalized patients. We hypothesized that the proportions of bacteremia from gram-positive and fungal pathogens have decreased over time, whereas rates of gram-negative bacteremia have increased as a result of better central venous catheter management. Methods: All U.S. Centers for Disease Control and Prevention-defined BSIs in patients treated on the general surgery and trauma services at our institution between January 1, 1998, and December 31, 2009 were identified prospectively. These cases were analyzed on a yearly basis to compare rates of various infections over time. The Cochran-Armitage test for trend was used to evaluate categorical data, whereas the Jonckheere-Terpstra test for ordered values was used to analyze continuous data. Results: A total of 1,040 patients had 1,441 episodes of BSI caused by 1,632 strains of bacteria or fungi. There was no difference over time in the proportion of BSI among overall infections. Rates of BSI for gramnegative and fungal pathogens increased over time (p = 0.03 and < 0.0001, respectively), whereas rates of grampositive BSI decreased (p < 0.0001). Positive changes in anaerobic BSI approached statistical significance. Conclusion: Although our hypothesis was only partly true, over the last 12 y, our institution clearly has witnessed a shift in the types of organisms causing BSIs. There was a decrease in the rates of BSI caused by gram-positive pathogens with an associated increase in the rates of BSI of infections by fungal and gramnegative pathogens. Interventions to reduce institutional rates of BSI should include targeted therapies based on historical institutional trends.

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“…Peripherally inserted central catheters (PICCs) have been popular because of their safety, easy insertion, and lower rates of infection [8–10]. Although the use of central venous catheters (CVCs) and Hickman catheters is a reported cause of catheter-line associated bloodstream infection (CLABSI) due to T. pulmonis [7], PICC-related bloodstream infections with this organism have not been reported.…”

Section: Introductionmentioning

confidence: 99%

Peripherally inserted central catheter-related bloodstream infection due to Tsukamurella pulmonis: a case report and literature review

Suzuki¹,

Sasahara²,

Tomita³

et al. 2017

BMC Infect Dis

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Background Tsukamurella pulmonis is an aerobic gram-positive and rod-shaped organism that causes central catheter-related bloodstream infections in immunocompromised hosts. However, peripherally inserted central catheter (PICC)-related bloodstream infections due to this organism have not been reported.Case presentationWe describe a case of a 48-year-old man with acquired immunodeficiency syndrome and diffuse large B cell lymphoma who received five courses of chemotherapy including rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone via a PICC. Five days after the last chemotherapy course, he presented with a high fever and shaking chills. His absolute neutrophil count was 4200/μL. Cultures obtained from blood and PICC culture revealed T. pulmonis. The colony count of T. pulmonis grown from PICC culture was 103 colony-forming units. Therefore, he was diagnosed with T. pulmonis bacteremia resulting from PICC-related bloodstream infection. The patient’s condition improved and he became afebrile within 48 h after intravenous administration of cefozopran hydrochloride, which is a fourth generation cephalosporin.ConclusionsPICCs can be associated with T. pulmonis bacteremia, and fourth generation cephalosporins may be effective treatment.

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Peripherally Inserted Central Catheters May Lower the Incidence of Catheter-Related Blood Stream Infections in Patients in Surgical Intensive Care Units

Cited by 89 publications

References 27 publications

Peripherally Inserted Central Catheter-Related Infections in a Cohort of Hospitalized Adult Patients

Peripherally Inserted Central Catheter-Related Infections in a Cohort of Hospitalized Adult Patients

Temporal Trends in Blood Stream Infection Isolates from Surgical Patients

Peripherally inserted central catheter-related bloodstream infection due to Tsukamurella pulmonis: a case report and literature review

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