Peripheral γδ T Cell Receptor-Bearing Lymphocytes Are Increased in Children with Celiac Disease

Klemola, Timo; Tarkkanen, Jussi; Örmälä, Timo; Saxén, Harri; Savilahti, E

doi:10.1097/00005176-199405000-00005

Cited by 9 publications

(3 citation statements)

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“…The TCR Vδ1 chain is normally restricted to the mucosa, but in HIV patients in whom virus replicates in the intestine, Vδ1 IEL are increased not only in the intestine 26 but in the blood 27. The mucosal immune response to dietary gluten in celiac disease is associated with an increase in intestinal IEL 28 and circulating mucosal TCR δ1 T cells 29. Circulating γδ T cells are also increased in Behcet's syndrome, characterized by mucosal ulceration 30.…”

Section: Discussionmentioning

confidence: 99%

Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra‐intestinal sites

2007

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Cells with the phenotype of intraepithelial lymphocytes (IEL) are present systemically and have been implicated in immune regulation. To determine whether IEL undergo homeostatic proliferation and migrate from the small intestine, we analysed the fate of congenic IEL transferred into lymphopenic mice. Donor IEL homed to the small intestinal epithelium, where they expanded in an IL-15-dependent manner and expressed CD69, CD44 and CD103; proliferation did not occur in the spleen, the main other site of IEL detection early after transfer. By 12 days after transfer, a small proportion of intestinal IEL had up-regulated the trafficking molecule CD62L. Four weeks after transfer, donor IEL with a CD69 -CD44 hi CD103 -phenotype similar to memory T cells were present in spleen and other extra-intestinal sites. Treatment of mice with blocking antibody to CD62L reduced appearance of cells in mesenteric lymph nodes; treatment with FTY720, a sphingosine 1-phosphate receptor agonist that blocks egress of T cells from lymph nodes, reduced appearance of cells in spleen. The distribution of TCR ab and cd IEL varied between organs, ab IEL being predominant. IEL proliferation and emigration under lymphopenic conditions suggests similar IEL turnover, albeit at a lower level, under physiological conditions.

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Section: Discussionmentioning

confidence: 99%

Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra‐intestinal sites

2007

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“…Of 57 biopsy specimens from paediatric patients, 44 have been described in earlier studies [6,9]. Of 21 adult patients, 13 came from a family study [10].…”

Section: Subjectsmentioning

confidence: 99%

Density of γ/δ+ T cells in the jejunal epithelium of patients with coeliac disease and dermatitis herpetiformis is increased with age

Savilahti

Örmälä

Arató

et al. 1997

Clinical and Experimental Immunology

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SUMMARYIncreased density of g/d T cell receptor (TCR) þ intraepithelial lymphocytes is the only characteristic in the jejunum of patients with coeliac disease and dermatitis herpetiformis which is not normalized on a gluten-free diet. We explored the age-dependent changes in intraepithelial g/d and a/b TCR þ cells from 137 biopsies from patients with coeliac disease and dermatitis herpetiformis and from controls. Biopsy specimens from 100 patients with coeliac disease and dermatitis herpetiformis and from 37 controls were studied with an immunohistochemical method using MoAbs to T cell receptors and peroxidase staining. An increase in the density of intraepithelial g/d T cells above the mean þ2 s.d. of the density in controls was present in 97 of 100 specimens from patients with coeliac disease and dermatitis herpetiformis. The density of g/d þ cells of patients with coeliac disease and dermatitis herpetiformis on a normal gluten-containing diet showed a positive correlation with age (r ¼ 0 . 45, P < 0 . 0001). In controls, the density of g/d þ cells remained low throughout the age-range studies, from age 0 . 6-57 years. In controls, a/b þ cells increased with age (r ¼ 0 . 57, P < 0 . 001). The increase in density of intraepithelial lymphocytes with age is in agreement with their thymus-independent character and local proliferation.

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“…Histopathologic studies show that lymphocytes, predominantly of the CD8 + cytotoxic‐suppressor phenotype, are prominent in the intraepithelial space, and γ/δ‐T cells are increased in the jejunal mucosa and the peripheral blood (41). Recent evidence suggests that celiac disease is associated with increased mucosal activity of tissue transglutaminase (tTGase) on specific protein‐bound glutamine (42).…”

Section: Immunoglobulin E‐mediated Disordersmentioning

confidence: 99%

Summary and Recommendations: Classification of Gastrointestinal Manifestations Due to Immunologic Reactions to Foods in Infants and Young Children

Sampson,

Anderson,

Simpson

et al. 2000

J. pediatr. gastroenterol. nutr.

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Peripheral γδ T Cell Receptor-Bearing Lymphocytes Are Increased in Children with Celiac Disease

Cited by 9 publications

References 0 publications

Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra‐intestinal sites

Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra‐intestinal sites

Density of γ/δ+ T cells in the jejunal epithelium of patients with coeliac disease and dermatitis herpetiformis is increased with age

Summary and Recommendations: Classification of Gastrointestinal Manifestations Due to Immunologic Reactions to Foods in Infants and Young Children

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