Peripheral viral challenge exacerbates experimental autoimmune encephalomyelitis

Petrisko, Tiffany J; Konat, G.

doi:10.1007/s11011-019-0383-y

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…Besides M. tuberculosis ( 339 ) and Pertussis toxin (induces IL-6 and reduces Treg compartment) ( 340 ) that are usually used for immune stimulation to induce EAE in mice, other infectious agents have been used prior or post-immunization with MOG 33−35 like SEB ( 341 ) or LPS ( 342 ), exacerbation of MOG-induced EAE by intraperitoneal injections of a viral mimetic, polyinosinic-polycytidylic acid (PIC) ( 343 ), Cytomegalovirus infection ( 344 ) which induces susceptibility to EAE in resistant BALB/c mice ( 345 ), Influenza virus infection ( 346 ) by enhanced type I T cell infiltration. 2′-5′ oligoadenylate synthetase-like 1 (OASL1) deficient (Oasl1 −/− ) mice are resistant to viral infections, as OASL1 specifically inhibits the translation of interferon regulatory factor 7 (IRF7), the master transcription factor for interferon-1 (IFN-I).…”

Section: Are Mog and Mog-igg-induced Animal Models Good Models For Mo...mentioning

confidence: 99%

Delimiting MOGAD as a disease entity using translational imaging

Oertel,

Hastermann,

Paul

2023

Front. Neurol.

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The first formal consensus diagnostic criteria for myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) were recently proposed. Yet, the distinction of MOGAD-defining characteristics from characteristics of its important differential diagnoses such as multiple sclerosis (MS) and aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder (NMOSD) is still obstructed. In preclinical research, MOG antibody-based animal models were used for decades to derive knowledge about MS. In clinical research, people with MOGAD have been combined into cohorts with other diagnoses. Thus, it remains unclear to which extent the generated knowledge is specifically applicable to MOGAD. Translational research can contribute to identifying MOGAD characteristic features by establishing imaging methods and outcome parameters on proven pathophysiological grounds. This article reviews suitable animal models for translational MOGAD research and the current state and prospect of translational imaging in MOGAD.

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