Peripheral Vascular Responses in Atopic Dermatitis

Allergy Diagnosis in Atopic Eczema with the Atopy Patch Test

“…They did not differ significantly from the control subjects during or after any of the other stressors, nor in the baseline periods before each stressor. The more pronounced vasoconstriction observed in normal room temperature (e.g., Abrams & Farber, 1963;Johnson & Winkelmann, 1965) was not reflected in the baseline peripheral vasomotor response or skin temperature data. Furthermore, these variables did not display greater reactivity or slower recovery to the stressors.…”

“…Eyster, Roth and Kierland (1952) found that atopic dermatitis sufferers displayed more rapid cooling and slower rewarming of toe, finger, thorax and forehead skin temperature than controls. Abrams and Farber (1963) found they had a lower finger temperature in a warm room. Moderately and severely affected males also tended to show lower resting digital blood flow than male controls, but this difference was not observed for female subjects.…”

“…However, there is some evidence to suggest sympathetic dominance of the autonomic nervous system. This is reflected by lower resting skin temperature (Abrams & Farber, 1963;Johnson & Winkelmann, 1965) and digital blood flow (Abrams & Farber, 1963), greater reactivity in skin temperature changes to cooling (Eyster, Roth, & Kierland, 1952;Johnson & Winkelmann, 1965), greater reactivity in blood pressure (Eyster et al, 1952) and heart rate (Wenger, Clemens, and Cullen, 1962) changes to the cold pressor, as well as slowness of recovery in heart rate, electromyograph , and skin temperature (Eyster et al, 1952).…”

Vascular pattern of the palms – a clinical feature of atopic skin diathesis

“…Non‐invasive measurement of the vascular dynamics of dermographism by laser Doppler flowmetry and an infrared thermocamera support the hypothesis that white dermographism depends on the degree of local vasoconstriction, possibly in combination with altered blood flow in cutaneous shunt vessels (23). Furthermore, the individual's sensitivity to thermal stimuli and paradoxical reactions to temperature changes are well known phenomena (24–26). Borelli and Kopecka (27) as well as Koscard et al (28) observed that, in atopic patients, heating of one arm caused cooling of the other unaffected arm, as a result of vasoconstriction of the skin vessels.…”

Pharmacological abnormalities in atopic dermatitis

“…A number of reactions to temperature change have been observed. These include reduced acral skin temperature (8), rapid vasoconstriction in ambient cold, and slow vasodilation during re warming (8,9).…”