Peripheral Ulcerative Keratitis Associated With Large Vessel Vasculitis

Abstract

Peripheral ulcerative keratitis (PUK) is a non-infectious ulcer at the peripheral corneal stroma. Autoimmune diseases can cause PUK, but PUK caused by large vessel vasculitis (LVV) has rarely been reported. We report the case of a 71-year-old woman with complaints of low-grade fever and left eye pain. Ophthalmologic examination revealed PUK in the left eye, and we diagnosed LVV by 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) findings. The patient was treated with topical betamethasone eye drops for PUK and oral prednisolone for LVV. This case suggests that LVV can cause PUK.

Peripheral ulcerative keratitis due to systemic diseases

“…Granulomatosis with polyangiitis [45,55] Polyarteritis nodosa [56] Microscopic polyangiitis [57] Eosinophilic granulomatosis with polyangiitis [58] Sarcoidosis [59--61] Behcet's disease [62] Takayasu arteritis Temporal arteritis [63,64] Leukocytoclastic vasculitis [65,66] Cryoglobulinemia [67] IgA vasculitis [57] Atypical HUS [68] Erythema elevatum diutinum [66,69] Systemic infections Herpes simplex virus (HSV) [70--72] Varicella zoster virus (VZV) [73,74] Tuberculosis (Tb) [75,76] Syphilis [77] Bartonella [78] Salmonella gastroenteritis [79] Acquired immune deficiency syndrome [ Hidradenitis suppurativa [93,94] Pityriasis rubra pilaris [95] Drug Induced Checkpoint inhibitors [96--98] Paraquat [99] Rituximab [100] Postvaccine [101] Perifosine [102] Immune reconstitution following antiretrovirals [103] Methamphetamine [104] Other autoimmune Antimyelin oligodendrocyte protein [105,106] IgG4 disease [107] Autoimmune hepatitis [108] Systemic onset juvenile idiopathic arthritis (JIA) [109] Chronic granulomatous disease [110] Local Insults: Microbial keratitis, including bacterial, fungal, viral, mycobacterial, and acanthamoeba Staphylococcal marginal keratitis Postsurgical…”