Peripheral tumor and tumor-like neurogenic lesions

Abreu, Evandro; Aubert, Sébastien; Wavreille, G.; Gheno, Ramon; Canella, Clarissa; Cotten, Anne

doi:10.1016/j.ejrad.2011.04.036

Cited by 112 publications

(95 citation statements)

References 24 publications

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“…10,11,14 Typically, it has been challenging to distinguish between peripheral NST types using ultrasound alone. 1 However, the position of the tumor relative to the nerve may provide supportive evidence. In particular, schwannomas characteristically appear as elongated spindle-shaped masses oriented longitudinally and eccentrically in relation to the nerve, displacing normal nerve tissue.…”

Section: Discussionmentioning

confidence: 99%

High-resolution ultrasonography and diffusion tensor tractography map normal nerve fascicles in relation to schwannoma tissue prior to resection

Simon¹,

Cage

Narvid

et al. 2014

JNS

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Section: Discussionmentioning

confidence: 99%

High-resolution ultrasonography and diffusion tensor tractography map normal nerve fascicles in relation to schwannoma tissue prior to resection

Simon¹,

Cage

Narvid

et al. 2014

JNS

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“…58,59 In the past, this condition has been referred to as fibrolipomatous hamartoma of a nerve or neural fibrolipoma. It most commonly affects the upper extremity (78-96% of cases) with a marked predilection for the median nerve (85% of reported cases) and its branches.…”

Section: Musculoskeletal Hamartomasmentioning

confidence: 99%

Hamartomas from head to toe: an imaging overview

Herrán

Restrepo

Gomez

et al. 2017

The British Journal of Radiology

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Hamartomas are tumours composed of mesenchymal tissues such as cartilage, fat, connective tissue and smooth muscle and can be found in virtually any organ system. These masses commonly develop sporadically, but are also seen in certain syndromes such as tuberous sclerosis or Carney triad. While their imaging appearance varies depending on the organ they arise from, findings are usually unique and a diagnosis can be confidently made. Radiologists must be aware of the clinical and imaging presentations of these lesions with the particular goal of avoiding unnecessary studies or invasive procedures. Furthermore, knowledge of common syndromic entities is crucial, as the radiologist may be the first to suggest the diagnosis.

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“…Malignant peripheral nerve sheath tumor is a spindle cell sarcoma arising from a peripheral nerve or its attendant sheath or from a benign PNST [ 50 ]. It does not include tumor arising from the epineurium or the vasculature of the peripheral nerves [ 72 ].…”

Section: Malignant Peripheral Nerve Sheath Tumor (Mpnst)mentioning

confidence: 99%

“…Sonography shows inhomogeneous hypoechoic masses that may have areas of hemorrhage, necrosis and calcifi cations [ 50 ]. A sonographic target sign is not present [ 53 ].…”

Section: Ultrasonographymentioning

confidence: 99%

Malignant Tumors of Peripheral Nerves

Kao

Parham

Fuller

2014

Pediatric Malignancies: Pathology and Imaging

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Malignant peripheral nerve sheath tumors (MPNST) represent a group of malignant spindle cell sarcomas with evidence of nerve sheath differentiation and/or arising from a peripheral nerve. Tumors showing origin from epineurial connective tissue or vascular structures are not considered to represent MPNST. Older/prior terminology for MPNST includes malignant neurilemmoma, malignant schwannoma, neurofi brosarcoma, and neurogenic sarcoma [ 1 ]. A number of histologic subtypes have been described. The majority are high grade aggressive sarcomas that show a strong tendency for local recurrence and metastases despite aggressive therapeutic measures [ 2 ]. Clinical Features and EpidemiologyThere is a strong association between MPNST and Neurofi bromatosis Type 1 (NF1), with 50 % of all MPNSTs arising within this patient population [ 3 ]. Approximately 10 % of individuals with NF1 will develop an MPNST over their lifetime, most of these tumors representing malignant degeneration occurring within preexisting plexiform neurofi bromas. One study of 476 NF1 patients documented a strong association between the presence of subcutaneous neurofi bromas and internal plexiform neurofi bromas, with an even stronger correlation between the presence of internal plexiform neurofi bromas and MPNST [ 4 ]. The remainder of MPNSTs will arise de novo, approximately 5-10 % representing radiation-induced sarcomas [ 1 ]. There is no particular gender predilection, and MPNSTs have been documented throughout a wide age range including children and the elderly. The majority however tend to present in adults with a median age in the mid 40s [ 5 ]. MPNSTs arising in the NF1 population tend to present up to a decade earlier, and these patients' tumors also tend to be larger [ 3 , 6 ].The majority of MPNST arise from larger peripheral nerves or within deep soft tissues, the most frequent sites including brachial plexus, sciatic, and paraspinal nerves, proximal upper and lower extremities, and buttock regions [ 5 ]. They have also been documented in a wide variety of locations throughout the body. Well over 50 cases of spinal MPNST have been reported [ 7 -13 ]. No particular spinal level is preferentially involved, and interestingly a significant proportion of spinal MPNST exhibit rhabdomyoblastic elements (Malignant Triton Tumor; see histologic description below) [ 14 -17 ]. MPNST represents one of the most aggressive tumors that may involve structures of the head and neck region [ 6 ]. It may arise from cranial nerves, particularly the vestibular [ 18 ], vagus [ 18 ], facial [ 18 , 19 ], and trigeminal [ 19 , 20 ]. Other sites include not only brachial plexus [ 21 ], but also scalp and bony structures (base of skull [ 22 -25 ], sinuses [ 26 , 27 ], and bones of the jaw) [ 28 , 29 ]

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Peripheral tumor and tumor-like neurogenic lesions

Cited by 112 publications

References 24 publications

High-resolution ultrasonography and diffusion tensor tractography map normal nerve fascicles in relation to schwannoma tissue prior to resection

High-resolution ultrasonography and diffusion tensor tractography map normal nerve fascicles in relation to schwannoma tissue prior to resection

Hamartomas from head to toe: an imaging overview

Malignant Tumors of Peripheral Nerves

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