Peripheral surgery triggers mast cells activation: Focusing on neuroinflammation

Bhuiyan, Piplu; Sun, Zhaochu; Chen, Yinan; Qian, Yanning

doi:10.1016/j.bbr.2023.114593

Cited by 3 publications

(3 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As the "first responder" cells of the CNS, mast cells are capable of sensing environmental stimuli and releasing numerous pro-inflammatory mediators, including histamine [40]. Histamine can activate adjacent sensory neurons and the nerve conduction pathway, potentially contributing to visceral pain development [21,41].…”

Section: Discussionmentioning

confidence: 99%

“…The balloon was carefully inserted into the colorectum 0.5 cm above the anus to induce colorectal distention. AWR scores were recorded in response to different colorectal pressures (20,40,60, or 80 mmHg), each applied for 20 s, with a 4 min break. AWR scoring criteria: 0, no significant behavioral changes; 1, immobility or head movement; 2, light contraction of abdominal muscles, but no lifting from the desktop; 3, clear contraction of abdominal wall muscles and lifting from the desktop; 4, arching of the abdominal wall and back.…”

Section: Assessment Of Visceral Sensitivitymentioning

confidence: 99%

See 1 more Smart Citation

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation

Chen,

Zhou,

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain. Although mast cells and corticotropin-releasing hormone (CRH) neurons are involved in stress response, whether there is an interaction between mast cells and CRH neurons in hypothalamic paraventricular nucleus (PVN) during the ELS-induced visceral hypersensitivity remains elusive. Herein, we established an NMS model by separating neonatal mice from their mothers, and observed that these mice presented visceral hypersensitivity in adulthood, as indicated by elevated abdominal withdrawal reflex and lowered visceral pain threshold. The NMS-induced adult visceral hypersensitivity was accompanied by activation of mast cells and CRH neurons in PVN. Also, NMS increased the histamine content (an inflammatory mediator mainly released by mast cells) and histamine H2 receptor (H2R) expression of CRH neurons in PVN. Remarkably, intra-PVN administration with mast cell stabilizer attenuated the NMS-induced CRH neuronal activation and adult visceral pain, while histamine administration showed the opposite effects. Moreover, intra-PVN injection with H2R antagonist alleviated the NMS-induced CRH neuronal activation, PKA and CREB phosphorylation, and importantly, adult visceral pain. Together, our findings revealed a role of an interaction between paraventricular mast cells and CRH neurons in NMS-induced adult visceral hypersensitivity, thereby providing a perspective for the management of visceral pain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Assessment Of Visceral Sensitivitymentioning

confidence: 99%

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation

Chen,

Zhou,

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…Compared to aging, chronic diseases (e.g., IBD and silicosis) are characterized by significantly different peripheral immune profiles, such as increased IL1β + DCs and monocytes, enrichment of γδ T-cell subsets, and up-regulated expression of HLA-DR, a marker of T-cell (CD3 + , CD4 + , and CD8 + ) activation ( Brilland et al, 2019 ; Boland et al, 2020 ; Mitsialis et al, 2020 ). Acute inflammatory stress also differs from chronic peripheral inflammation in the initial phase, the former is often accompanied by short-term exacerbations and intense immune cell activation, aggregation, and inflammatory storm formation, often with highly activated macrophages, neutrophils, and mast cells mediating activation of innate intrinsic immunity, e.g., COVID-19 and surgically-induced aseptic injury ( Joaquim et al, 2022 ; Bhuiyan et al, 2023 ). Some acute inflammatory events can be followed by transformation into chronic inflammatory processes, e.g., long COVID-19, with long-term neurocognitive effects ( Joaquim et al, 2022 ).…”

Section: Mechanisms By Which Peripheral Inflammation Promotes Central...mentioning

confidence: 99%

Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications

Tan,

Chen,

Kong

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

Cognitive impairments, such as learning and memory deficits, may occur in susceptible populations including the elderly and patients who are chronically ill or have experienced stressful events, including surgery, infection, and trauma. Accumulating lines of evidence suggested that peripheral inflammation featured by the recruitment of peripheral immune cells and the release of pro-inflammatory cytokines may be activated during aging and these conditions, participating in peripheral immune system-brain communication. Lots of progress has been achieved in deciphering the core bridging mechanism connecting peripheral inflammation and cognitive impairments, which may be helpful in developing early diagnosis, prognosis evaluation, and prevention methods based on peripheral blood circulation system sampling and intervention. In this review, we summarized the evolving evidence on the prevalence of peripheral inflammation-associated neurocognitive impairments and discussed the research advances in the underlying mechanisms. We also highlighted the prevention and treatment strategies against peripheral inflammation-associated cognitive dysfunction.

show abstract

Research Progress on the Effect of Neuroinflammation on Postoperative Cognitive Dysfunction

赵

2024

JCPM

View full text Add to dashboard Cite

Peripheral surgery triggers mast cells activation: Focusing on neuroinflammation

Cited by 3 publications

References 116 publications

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation

Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications

Research Progress on the Effect of Neuroinflammation on Postoperative Cognitive Dysfunction

Contact Info

Product

Resources

About