Peripheral streptomycin/lidocaine injections in the treatment of idiopathic trigeminal neuralgia

Sokolović, Momir; Todorović, Ljubomir; Stajčić, Zoran; Petrović, V

doi:10.1016/s0301-0503(86)80249-1

Cited by 20 publications

(3 citation statements)

References 11 publications

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“…The protocol used in this study does not support the findings of Sokolovic et al, who reported that sixteen patients out of twenty remained pain free after periods of 30 months. 18 Our results also do not support the findings of Stajcic et al who used a similar double blind protocol, and found that streptomycin/lidocaine injections are initially effective in the treatment of trigeminal neuralgia. 22…”

Section: Group Baselinecontrasting

confidence: 99%

The Effects of Streptomycin/Lidocaine Block on Trigeminal Neuralgia: A Double Blind Crossover Placebo Controlled Study

Bittar

Graff‐Radford

1993

Headache

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This study investigated the long term effect of a peripheral sensory block using streptomycin sulphate on trigeminal neuralgia. A total of twenty subjects, thirteen with idiopathic trigeminal neuralgia (ITN) and seven with traumatic trigeminal neuralgia (TTN) were studied. A double-blind placebo controlled randomized design was used. After the clinical assessment subjects were randomly assigned to receive either 1 g of streptomycin with 3 ml 2% lidocaine, or 3 ml lidocaine alone. The injections were performed adjacent to the branches that served the painful site. These were intraoral injections, more specifically infraorbital and inferior alveolar blocks. Patients received five blocks of either streptomycin/lidocaine or lidocaine alone for a period of five consecutive weeks. On the sixth week they were crossed over. Measures of pain intensity and pain frequency were used to assess treatment outcome. Patients also recorded their side-effects. Repeated measures analysis of variance was used to compare the treatment outcomes between the active and placebo groups. There was no statistically significant differences in the treatment outcomes regarding frequency and intensity of pain attacks. The sensory function of the treated nerves was also not affected. Side effects including facial swelling and pain were a common finding in the patients receiving streptomycin. This study demonstrated no beneficial effects of streptomycin blockade for idiopathic and traumatic trigeminal neuralgia.

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Section: Group Baselinecontrasting

confidence: 99%

The Effects of Streptomycin/Lidocaine Block on Trigeminal Neuralgia: A Double Blind Crossover Placebo Controlled Study

Bittar

Graff‐Radford

1993

Headache

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“…Many treatment modalities have been described for trigeminal neuralgia from time to time. These include drug therapy (carbamazepine, phenytoin, baclofen, gabapantane),[ 2 ] peripheral techniques viz injection of alcohol,[ 4 5 ] phenol, streptomycin and lignocaine,[ 6 ] neurectomies,[ 7 ] peripheral radio frequency thermolysis,[ 8 ] and removal of jaw cavities. [ 9 ] Neurosurgery includes radiofrequency thermocoagulation of trigeminal ganglion,[ 10 ] glycerol injections,[ 11 ] posterior fossa surgery, either microvascular decompression[ 12 ] or partial rhizotomy.…”

Section: Introductionmentioning

confidence: 99%

Role of transcutaneous electric nerve stimulation in the management of trigeminal neuralgia

Singla

Prabhakar

Singla

2011

Journal of Neurosciences in Rural Practice

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Background:Trigeminal neuralgia typically involves nerves supplying teeth, jaws and face of older females. Though the etiology is usually obscure, different treatment modalities have been tried for it viz. medicinal treatment, injection alcohol, peripheral neurectomy, rhizotomy, and microvascular decompression etc. Transcutaneous electric nerve stimulation (TENS) is an emerging and promising option for management of such patients.Aims and Design:The present study was designed with an aim to study the efficacy of TENS in management of trigeminal neuralgia.Materials and Methods:The study was conducted on 30 patients of trigeminal neuralgia confirmed by diagnostic nerve block. They were given bursts of TENS for 20-40 days over the path of the affected nerve and subsequently evaluated at 1 month and 3 month intervals by visual analogue scale (VAS), verbal pain scale (VPS), a functional outcome scales for main daily activities like sleep, chewing, talking, or washing face.Results:The results showed that, on VAS, the score decreased from 8.9 (Pre TENS) to 3.1 at 1 month and 1.3 at 3 months, and on VPS, the score decreased from 3.5 (Pre TENS) to 1.2 at 1 month and 0.3 at 3 months. Similarly, a considerable decrease in scores was seen on functional outcome scale for different activities. No side effects like irritation or redness of skin were seen in any of the patients.Conclusions:Thus, TENS was found to be a safe, easily acceptable, and non-invasive outdoor patient department procedure for management of trigeminal neuralgia.

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“…The earliest report of use of streptomycin in dentistry for facial pains was in the year 1963. [21] After 18 years, Sokolovic et al [4] started using streptomycin in cases of ITN. He concluded that, among 20 patients of the study, 10 patients were completely pain free after 30 month follow-up, six patients missed their follow-up after 2-18 months, but were pain free when last seen and in four patients the pain had recurred 18-30 months after treatment.…”

Section: Streptomycin As a New Treatment Modalitymentioning

confidence: 99%

Streptomycin-lidocaine injections for the treatment of postherpetic neuralgia: Report of three cases with literature review

Waghray¹,

Asif²,

Duddu³

et al. 2013

Eur J Dent

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The sudden, stabbing, paroxysmal pain of neuralgia is the fiercest agony that a patient may experience in his life. Many varied medical treatments and surgical procedures have been suggested in the literature for neuralgic pain. Most of the patients fail to respond to medical treatments or succumb to complications of total anesthesia owing to surgical procedures. Herein, we tried a new treatment modality in patients suffering from postherpetic neuralgia with appreciable success in all the three cases that are presented in this paper. Streptomycin sulfate dissolved in 2% lidocaine solution was deposited at the peripheral branches on the involved nerves targeting the trigger zones, given weekly once for a maximum of 6 week period and continued once in 2 weeks if symptoms persisted. All patients were followed-up for 1 year and there was a marked improvement on follow-up.

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Peripheral streptomycin/lidocaine injections in the treatment of idiopathic trigeminal neuralgia

Cited by 20 publications

References 11 publications

The Effects of Streptomycin/Lidocaine Block on Trigeminal Neuralgia: A Double Blind Crossover Placebo Controlled Study

The Effects of Streptomycin/Lidocaine Block on Trigeminal Neuralgia: A Double Blind Crossover Placebo Controlled Study

Role of transcutaneous electric nerve stimulation in the management of trigeminal neuralgia

Streptomycin-lidocaine injections for the treatment of postherpetic neuralgia: Report of three cases with literature review

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