Peripheral stimuli excite coronal beams of Golgi cells in rat cerebellar cortex

Volny-Luraghi, Antonia; Maex, Reinoud; Vos, Bart P.; Schutter, Erik De

doi:10.1016/s0306-4522(02)00196-3

Cited by 27 publications

(23 citation statements)

References 40 publications

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“…The influence of PF was confirmed by the observation that pairs of Golgi cells aligned along the same PF beam display high levels of spike synchronization at rest and during peripheral stimulations, whereas parasagittally aligned pairs fire independently (VolnyLuraghi et al 2002;Vos et al 1999a). The spike correlation was modulated with sensory stimulation in agreement with a model in which stronger parallel fiber inputs trigger earlier spikes in Golgi cells Volny-Luraghi et al 2002). The second phase of the Golgi cell response to peripheral stimulations consists in a firing pause which immediately follows the early excitation, when present, and lasts from 30 to 50 ms Vos et al 1999b).…”

Section: Golgi Cells Display a Complex Triphasic Response To Periphersupporting

confidence: 76%

Golgi Neurons

Pietrajtis

Dieudonné

2013

Handbook of the Cerebellum and Cerebellar Disorders

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The Golgi cell is an essential cellular component of the cerebellar cortex and the only source of inhibition to the billions of granule cells forming the cortical input layer. While considered as a single neuronal class, separate from Lugaro cells, Golgi cells form a highly heterogeneous population, both morphologically and immunohistochemically. Golgi cells are interconnected by electrical synapses and connected to other cortical cell types by chemical synapses, forming feedforward and feedback inhibitory loops onto granule cells. Golgi cells are thus ideally placed to control the gain and temporal pattern of granule cell discharge in response to afferent mossy fiber activity.In vivo Golgi cells fire irregularly and respond to peripheral stimuli with brief burst responses or prolonged pauses. In the behaving animal, the firing rate of Golgi cells is modulated and forms sensory-motor receptive fields. Furthermore, Golgi cell activity is coordinated with local field potential oscillations in the beta range both locally and along the parallel fiber beams. Detailed computer models have been generated and predict complex oscillatory behaviors of the granule cell layer network at various frequencies. The impact of these oscillations on the encoding capacity of the granular layer is still debated, and further recordings are needed to understand how Golgi cells affect granule cell spike timing.

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Section: Golgi Cells Display a Complex Triphasic Response To Periphersupporting

confidence: 76%

Golgi Neurons

Pietrajtis

Dieudonné

2013

Handbook of the Cerebellum and Cerebellar Disorders

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“…However, because it was not possible to completely map the receptive fields within the recording time available, there was a bias toward tactile stimuli evoking stronger GoC responses, and it was previously assumed that primarily parallel-fiberevoked GoC responses are weak (Vos et al 1999b). Previous work demonstrating synchronization of GoCs along the parallel fiber axis (Volny-Luraghi et al 2002;Vos et al 1999a) also supports GoC activation by parallel fiber synapses. For the responses studied here, the broad activation (Fig.…”

Section: Origins Of Response Variationmentioning

confidence: 55%

“…Morissette and suggested the later response peak to be of corticopontine origin, as it disappeared after S1 inactivation and as its variable latency strongly correlated with the S1 response latency at the single trial level. However, a modeling study could not exclude the slowly propagating parallel fibers as a secondary source of excitation (Volny-Luraghi et al 2002), and alternative pathways exist (see DISCUSSION). In addition, both the initial burst-like response and the long-lasting suppression could reflect the activation of afferent synapses or, alternatively, be generated by intrinsic membrane mechanisms (Solinas et al 2007).…”

mentioning

confidence: 99%

Current source density correlates of cerebellar Golgi and Purkinje cell responses to tactile input

Tahon

Wijnants

Schutter

et al. 2011

Journal of Neurophysiology

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Tahon K, Wijnants M, De Schutter E, Maex R. Current source density correlates of cerebellar Golgi and Purkinje cell responses to tactile input. J Neurophysiol 105: 1327-1341, 2011. First published January 12, 2011 doi:10.1152/jn.00317.2010The overall circuitry of the cerebellar cortex has been known for over a century, but the function of many synaptic connections remains poorly characterized in vivo. We used a one-dimensional multielectrode probe to estimate the current source density (CSD) of Crus IIa in response to perioral tactile stimuli in anesthetized rats and to correlate current sinks and sources to changes in the spike rate of corecorded Golgi and Purkinje cells. The punctate stimuli evoked two distinct early waves of excitation (at Ͻ10 and ϳ20 ms) associated with current sinks in the granular layer. The second wave was putatively of corticopontine origin, and its associated sink was located higher in the granular layer than the first trigeminal sink. The distinctive patterns of granular-layer sinks correlated with the spike responses of corecorded Golgi cells. In general, Golgi cell spike responses could be linearly reconstructed from the CSD profile. A dip in simple-spike activity of coregistered Purkinje cells correlated with a current source deep in the molecular layer, probably generated by basket cell synapses, interspersed between sparse early sinks presumably generated by synapses from granule cells. The late (Ͼ30 ms) enhancement of simple-spike activity in Purkinje cells was characterized by the absence of simultaneous sinks in the granular layer and by the suppression of corecorded Golgi cell activity, pointing at inhibition of Golgi cells by Purkinje axon collaterals as a likely mechanism of late Purkinje cell excitation. in vivo electrophysiology; local field potential; microcircuit; multielectrode recording; synaptic current FOR A LONG TIME, THE CEREBELLUM has been considered to be primarily, if not exclusively, a motor organ as lesions cause symptoms such as ataxia, dysmetria, tremor, and hypotonia (Holmes 1939). Research of the past decades revealed more of its true nature: a neural substrate processing massive sensory information and serving not only motor, but also nonmotor regions

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“…These terminals (the rosettes) make synaptic contact with dendrites of granule cells and with Golgi cells (Palay and Chan-Palay, 1974;Vos et al, 1999;Castejon and Castejon, III. BRAINSTEM AND CEREBELLUM 2000;Volny-Luraghi et al, 2002;Kanichay and Silver, 2008). The synaptic complex composed of the mossy fiber rosettes, the granule cell dendrites, and the inhibitory terminals of the Golgi cells is known as the cerebellar glomerulus.…”

Section: Afferents Of the Cerebellar Cortexmentioning

confidence: 99%