Peripheral spondyloarthritis: What have we learned?

Puche-Larrubia, María Ángeles; López-Medina, Clementina; Ziadé, Nelly

doi:10.1016/j.berh.2023.101862

Cited by 1 publication

(3 citation statements)

References 66 publications

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“…A subset of the included studies demonstrated a positive association between elevated RDW levels and disease activity in rheumatic diseases. [16][17][18][19][20][21][22][23][24][25][26][27][28][29]48 This observation is in line with emerging evidence that RDW may serve as an indicator of systemic inflammation. Increased RDW has been linked to the release of pro-inflammatory cytokines and oxidative stress, both of which are hallmark features of autoimmune rheumatic diseases.…”

Section: Discussionsupporting

confidence: 71%

“…Although several different disease activity scores have been validated for RA, controversy exists regarding their accuracy in the assessment of disease activity, particularly in patients with fibromyalgia. 19 …”

Section: Resultsmentioning

confidence: 99%

“…18 Although several different disease activity scores have been validated for RA, controversy exists regarding their accuracy in the assessment of disease activity, particularly in patients with fibromyalgia. 19 Da Silva et al 20 have demonstrated a discrepancy between ultrasound synovitis scores and each of the Disease Activity Score 28 (DAS 28), the Simplified Disease Activity Index (SDAI) or the Clinical Disease Activity Index (CDAI) in the assessment of disease activity in patients with RA and concomitant fibromyalgia.…”

Section: Rheumatoid Arthritis and Rdwmentioning

confidence: 99%

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Red Blood Cell Distribution Width: A Potential Inexpensive Marker for Disease Activity in Patients with Rheumatic Diseases; Scoping Review

Alghamdi

2023

OARRR

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Background Rheumatic diseases encompass a diverse group of autoimmune disorders that affect the joints and connective tissues. The red blood cell distribution width (RDW) has been widely investigated as an inflammatory marker. This scoping review aimed to explore the potential utility of RDW as an inexpensive marker for disease activity in patients with rheumatic diseases. By summarizing the available evidence, we aimed to determine whether RDW can serve as a reliable and accessible indicator of disease activity in these patients. Methods A comprehensive search was systematically performed across electronic databases, encompassing PubMed, Embase, and Web of Science. Studies have explored the relationship between RDW and disease activity in rheumatic diseases. Data extraction focused on the study characteristics, methodologies, and findings related to RDW as a disease activity marker. Results After removing duplicates, the initial search yielded 25 relevant studies. These studies encompassed a variety of rheumatic diseases, with rheumatoid arthritis being the most frequently studied condition. The association between RDW and disease activity was assessed by using various disease activity indices and clinical parameters. While some studies have reported a significant correlation between elevated RDW and disease activity, others have yielded inconclusive results. Conclusion From this review, we concluded that RDW is an inexpensive potential marker for the evaluation of disease activity in rheumatic diseases. RDW is promising as an inexpensive and readily available marker; however, its clinical utility in assessing disease activity in rheumatic conditions warrants more rigorous investigation through well-designed prospective studies.

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