Peripheral sequestration of huntingtin delays neuronal death and depends on N-terminal ubiquitination
Noam Ziv,
Ayub Boulos,
Dunia Maroun
et al.
Abstract:Huntington’s disease (HD) is caused by a glutamine repeat expansion in the protein huntingtin. The mutated protein (mHtt) forms aggregates whose impacts on neuronal survival are still debated. Using weeks-long, continual imaging of individual cortical neurons, we find that mHtt is gradually sequestrated into peripheral, mainly axonal aggregates, concomitant with dramatic reductions in cytosolic mHtt levels and enhanced neuronal survival. in-situ pulse-chase imaging reveals that aggregates continually gain and … Show more
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