Peripheral sensory neuropathy in type 2 diabetes patients: A case control study in Accra, Ghana

Puplampu, Peter; Boima, Vincent; Antwi, Daniel A.; Gyan, Ben; Amoah, Albert

doi:10.1016/j.jcte.2016.07.001

Cited by 20 publications

(21 citation statements)

References 23 publications

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“…Finally, the present study found a significant association between smoking habit and DPN. Other studies have also found a similar association [ 32 , 43 ]. The association between smoking and DPN can be explained by the fact that smoking causes neuropathy via neuronal ischemia from endothelial damage, increased inflammation, oxidative stress, interference with glucose metabolism, and from direct toxic effects on the neurons [ 48 ].…”

Section: Discussionsupporting

confidence: 73%

Prevalence and Determinants of Peripheral Neuropathy among Type 2 Adult Diabetes Patients Attending Jimma University Medical Center, Southwest Ethiopia, 2019, an Institutional-Based Cross-Sectional Study

Abdissa

Hamba

Kene

et al. 2020

Journal of Diabetes Research

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Background. Diabetes chronic complications are major causes of morbidity and mortality, among which diabetic peripheral neuropathy (DPN) stands out. One of the tools to screen DPN is the Michigan neuropathy screening instrument. However, there is no data compiled using this tool to assess the prevalence and its determinants in Jimma. So, the aim of this study was to assess the prevalence of DPN and its determinants among patients with diabetes mellitus at Jimma University Medical Center. Methods. A hospital-based cross-sectional study was conducted at Jimma University Medical Center on 366 type 2diabetic patients. Data were collected using pretested structured questionnaire and entered into EpiData 3.1 and exported to SPSS version 20 for analysis. Both bivariate and multivariate binary logistic regressions were employed to identify factors associated with DPN. A variable having a p value of < 0.25 in the bivariate model was subjected to multivariate analysis to avoid confounding variable’s effect. Adjusted odds ratios were calculated at 95% confidence interval and considered significant with a p value of ≤ 0.05. Results. The mean age of participants was 50.1±14.28 years. The study finding showed that the prevalence of DPN was 53.6% among study participants. According to the multivariate logistic regression age above 40 years (AOR=4.57; 95% CI: 1.50, 13.9), above 50 years (AOR=6.5; 95% CI: 2.24, 18.79), duration of diabetes above 5 years (AOR=3.06; 95% CI: 1.63, 5.77), duration above 10 years (AOR=7.1; 95% CI: 2.99, 17.28), physical inactivity (AOR=2.02; 95% CI: 1.14, 3.55), and smoking (current smoker AOR=7.96, 95% CI: 3.22, 19.64; former smoker (AOR=2.65; 95% CI: 1.22, 5.77) were independent predictors of DPN among study participants. Conclusion. Almost half of the study participants had DPN. Age above 40 years, diabetes duration of above 5 years, physical inactivity, and smoking were significantly associated with DPN. Early detection and appropriate interventions are important among patients with age above 40 years, physically inactive, smokers, and diabetes duration of above 5 years.

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Section: Discussionsupporting

confidence: 73%

Prevalence and Determinants of Peripheral Neuropathy among Type 2 Adult Diabetes Patients Attending Jimma University Medical Center, Southwest Ethiopia, 2019, an Institutional-Based Cross-Sectional Study

Abdissa

Hamba

Kene

et al. 2020

Journal of Diabetes Research

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“…Diabetes is now common in sub-Saharan African population and associated with macrovascular and microvascular complications [ 1 , 2 ]. Cardiovascular diseases are among the major causes of death in diabetes patients; however, studies have shown that microvascular disease is also associated with excess mortality [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana

Agyekum

Mensah

Affrim

et al. 2018

Journal of Diabetes Research

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Objective Peripheral sensory neuropathy (PSN) is among microvascular complications of diabetes that make patients prone to ulceration and amputation. Arterial stiffness is a predictor of cardiovascular diseases and microvascular complications associated with diabetes. We investigated the association between PSN and arterial stiffness, measured as aortic pulse wave velocity (PWVao) and cardio-ankle vascular index (CAVI). Method In a case-control design, arterial stiffness was measured in 240 diabetes patients and 110 nondiabetic control. Large-fibre nerve function was assessed by vibration perception threshold (VPT) using a neurothesiometer. PSN was defined as the VPT > 97.5th percentile from age- and gender-adjusted models in nondiabetic controls. Results The overall prevalence of PSN was 16.6% in the entire study participants. Compared to non-PSN participants, PSN patients had higher levels of PWVao (9.5 ± 1.7 versus 8.7 ± 1.2 m/s, p = 0.016) and CAVI (8.4 ± 1.3 versus 7.6 ± 1.1, p = 0.001). In multiple regression models, VPT was associated with PWVao (β = 0.14, p = 0.025) and CAVI (β = 0.12, p = 0.04). PSN patients had increased odds of CAVI (OR = 1.51 (1.02–2.4), p = 0.043), but not PWVao (OR = 1.25 (0.91–1.71), p = 0.173). Conclusion PWVao and CAVI were associated with VPT and PSN in diabetes patients in Ghana. Patients having PSN have increased odds of CAVI, independent of other conventional risk factors.

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“…Chronic adult diseases including hypertension, obesity, resulting metabolic syndrome and diabetes are now common [ 1 , 2 ]. Consequently, premature macro- and micro-vascular conditions, including hypertensive heart failure (if not yet much coronary disease), stroke, renal failure, and arterial complications of Type 2 diabetes (T2D) now burden patients and health services [ 3 , 4 ]. Arterial stiffness is a powerful predictor of such future cardiovascular (CV) complications and all-cause mortality in all patient groups studied, even after adjusting for age, blood pressure (BP) or other risk factors [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Arterial stiffness in hypertensive and type 2 diabetes patients in Ghana: comparison of the cardio-ankle vascular index and central aortic techniques

et al. 2016

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BackgroundDiabetes and hypertension increase arterial stiffness and cardiovascular events in all societies studied so far; sub-Saharan African studies are sparse. We investigated factors affecting arterial function in Ghanaians with diabetes, hypertension, both or neither.MethodTesting the hypothesis that arterial stiffness would progressively increase from controls to multiply affected patients, 270 participants were stratified into those with diabetes or hypertension only, with both, or without either. Cardio-ankle vascular index (CAVI), heart–ankle pulse wave velocity (haPWV), aortic PWV (PWVao) by Arteriograph, aortic and brachial blood pressures (BP), were measured.ResultsIn patients with both diabetes and hypertension compared with either alone, values were higher of CAVI (mean ± SD, 8.3 ± 1.2 vs 7.5 ± 1.1 and 7.4 ± 1.1 units; p < 0.05), PWVao (9.1 ± 1.4 vs 8.7 ± 1.9 and 8.1 ± 0.9 m/s; p < 0.05) and haPWV (8.5 ± 1 vs 7.9 ± 1 and 7.2 ± 0.7 m/s; p < 0.05) respectively. In multivariate analysis, age, having diabetes or hypertension and BMI were independently associated with CAVI in all participants (β = 0.49, 0.2, 0.17 and -0.2 units; p < 0.01, respectively). Independent determinants of PWVao were heart rate, systolic BP and age (β = 0.42, 0.27 and 0.22; p < 0.01), and for haPWV were systolic BP, age, BMI, diabetes and hypertension status (β = 0.46, 0.32, -0.2, 0.2 and 0.11; p < 0.01).ConclusionIn this sub-Saharan setting with lesser atherosclerosis than the western world, arterial stiffness is significantly greater in patients with coexistent diabetes and hypertension but did not differ between those with either diabetes or hypertension only. Simple, reproducibly measured PWV/CAVI may offer effective and efficient targets for intervention.Electronic supplementary materialThe online version of this article (doi:10.1186/s12902-016-0135-5) contains supplementary material, which is available to authorized users.

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Peripheral sensory neuropathy in type 2 diabetes patients: A case control study in Accra, Ghana

Abstract: HighlightsPSN was assessed by symptoms, examination and quantitative assessment.High burden of PSN in diabetes patients in Ghana.The major determinants of PSN using different assessment methods were reported.

Cited by 20 publications

References 23 publications

Prevalence and Determinants of Peripheral Neuropathy among Type 2 Adult Diabetes Patients Attending Jimma University Medical Center, Southwest Ethiopia, 2019, an Institutional-Based Cross-Sectional Study

Prevalence and Determinants of Peripheral Neuropathy among Type 2 Adult Diabetes Patients Attending Jimma University Medical Center, Southwest Ethiopia, 2019, an Institutional-Based Cross-Sectional Study

Arterial Stiffness Is Associated with Peripheral Sensory Neuropathy in Diabetes Patients in Ghana

Arterial stiffness in hypertensive and type 2 diabetes patients in Ghana: comparison of the cardio-ankle vascular index and central aortic techniques

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