“…Here, we used immunostaining, live imaging, biochemistry, and genetic approaches to examine the expression of advillin in axonal growth cones, the key structure that determines the destiny of neurite outgrowth. Then, we probed the roles of advillin in the context of nerve regeneration and neuropathic pain in: ( i ) a mouse model of multiple sclerosis induced by experimental autoimmune encephalomyelitis (EAE), a demyelinating autoimmune disease accompanied by severe sensory neuropathy ( 22 , 23 ); ( ii ) a peripheral neuropathy model induced by oxaliplatin, a drug used to treat colorectal cancer ( 24 ); and ( iii ) a localized nerve lesion model induced by chronic constriction injury (CCI) of the sciatic nerve ( 25 , 26 ).…”