Peripheral sensitization reduces laser-evoked potential habituation

Hüllemann, Philipp; Watfeh, R.; Shao, Yi; Nerdal, A; Binder, Andreas; Baron, Ralf

doi:10.1016/j.neucli.2015.10.088

Cited by 24 publications

(25 citation statements)

References 34 publications

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“…Habituation of evoked potentials, thought to involve both peripheral and central components (Hüllemann et al, 2013, 2015), has previously been reported (Greffrath et al, 2007; Smith et al, 2008; Hüllemann et al, 2013) and was not an unexpected finding in either of our experiments. It is, however, an obvious limitation in the utility of evoked potentials to explore the mechanisms of EIH and needs to be addressed in future studies that use these techniques.…”

Section: Discussionsupporting

confidence: 86%

Exploring the Mechanisms of Exercise-Induced Hypoalgesia Using Somatosensory and Laser Evoked Potentials

et al. 2016

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Exercise-induced hypoalgesia is well described, but the underlying mechanisms are unclear. The aim of this study was to examine the effect of exercise on somatosensory evoked potentials, laser evoked potentials, pressure pain thresholds and heat pain thresholds. These were recorded before and after 3-min of isometric elbow flexion exercise at 40% of the participant's maximal voluntary force, or an equivalent period of rest. Exercise-induced hypoalgesia was confirmed in two experiments (Experiment 1–SEPs; Experiment 2–LEPs) by increased pressure pain thresholds at biceps brachii (24.3 and 20.6% increase in Experiment 1 and 2, respectively; both d > 0.84 and p < 0.001) and first dorsal interosseous (18.8 and 21.5% increase in Experiment 1 and 2, respectively; both d > 0.57 and p < 0.001). In contrast, heat pain thresholds were not significantly different after exercise (forearm: 10.8% increase, d = 0.35, p = 0.10; hand: 3.6% increase, d = 0.06, p = 0.74). Contrasting effects of exercise on the amplitude of laser evoked potentials (14.6% decrease, d = −0.42, p = 0.004) and somatosensory evoked potentials (10.9% increase, d = −0.02, p = 1) were also observed, while an equivalent period of rest showed similar habituation (laser evoked potential: 7.3% decrease, d = −0.25, p = 0.14; somatosensory evoked potential: 20.7% decrease, d = −0.32, p = 0.006). The differential response of pressure pain thresholds and heat pain thresholds to exercise is consistent with relative insensitivity of thermal nociception to the acute hypoalgesic effects of exercise. Conflicting effects of exercise on somatosensory evoked potentials and laser evoked potentials were observed. This may reflect non-nociceptive contributions to the somatosensory evoked potential, but could also indicate that peripheral nociceptors contribute to exercise-induced hypoalgesia.

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Section: Discussionsupporting

confidence: 86%

Exploring the Mechanisms of Exercise-Induced Hypoalgesia Using Somatosensory and Laser Evoked Potentials

et al. 2016

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“…In the present study, receptor fatigue, that could lead to a progressive LEP amplitude reduction, can be excluded, since the laser pulses were delivered to close by different skin areas during LEP recording. Although reduced LEP habituation was demonstrated in a model of peripheral sensitization using topic application of capsaicin (Hüllemann et al, ), in the present study no peripheral sensitization was induced. Reduced EP habituation to painful stimuli can be also interpreted as a marker of abnormal nociceptive processing and/or cerebral cortex excitability, as in migraine (Valeriani et al, ), fibromyalgia (de Tommaso et al, , ) and cardiac syndrome X (Valeriani et al, ), that are diseases characterized by pain sine materia , and in neuropathic pain conditions, such as cervical radiculopathy (Hüllemann et al, ).…”

Section: Discussioncontrasting

confidence: 73%

ZNRD1‐AS and RP11‐819C21.1 long non‐coding RNA changes following painful laser stimulation correlate with laser‐evoked potential amplitude and habituation in healthy subjects: A pilot study

Santoro

Vollono

Pazzaglia

et al. 2020

European Journal of Pain

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Background Non‐coding RNAs (lncRNAs) are a group of non‐coding RNAs that act as regulators of gene expression; they are implicated in various human diseases and have been reported to be involved in the modulation of pain. We aimed to study whether: (a) lncRNAs modifications could be found in an experimental model of pain; (b) there was a correlation between lncRNA changes and laser evoked potential (LEP) amplitude/laser‐pain rating. Methods Laser evoked potentials were recorded from 11 healthy subjects to both left hand and perioral region stimulation. Three consecutive averages were calculated for each stimulation site in order to investigate the LEP amplitude habituation. Blood samples were obtained immediately before LEP recording (pre‐pain) and 30‐min after the recording of the last LEP average (post‐pain). Eighty‐four lncRNAs, involved in autoimmunity and human inflammatory response, were screened. The criteria used for lncRNAs analysis were fold change >2 and p < .05. By Real‐Time PCR, we identified two lncRNAs up‐regulated at the post‐pain time, as compared to the pre‐pain time: RP11‐819C21.1 (fold change = 8.2; p = .038) and ZNRD1 antisense RNA 1 non‐protein coding (ZNRD1‐AS; fold change = 6.3; p = .037). Results The ZNRD1‐AS up‐regulation was directly correlated with the N1 amplitude, while the RP11‐819C21.1 increase after pain showed a correlation with the reduced N2/P2 amplitude and laser‐pain habituation. Conclusion IncRNA changes in a human experimental phasic pain model. The correlation between lncRNA changes and LEP amplitude and habituation suggests that RP11‐819C21.1 and ZNRD1‐AS could be involved in the pathophysiology of painful diseases characterized by abnormal excitability of the cerebral cortex. Significance Long non‐coding RNAs are upregulated after experimental pain. RP11‐819C21.1 and ZNRD1 could be involved in the pathophysiology of diseases characterized by reduced habituation to pain.

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“…The aim was to compare the time course of LEP‐habituation between radiculopathy patients and healthy controls. A similar approach was recently reported using the capsaicin model for peripheral and central sensitization (Hüllemann et al., ). The time course of LEP‐habituation was assessed by applying 100 painful laser stimuli at the middle ventral thigh at the L3 dermatome (see below).…”

Section: Methodsmentioning

confidence: 87%

“…The main finding of the present investigation was a reduced LEP‐habituation in painful radiculopathy patients compared to healthy controls. LEP‐habituation is a physiological phenomenon, which is found in all healthy subjects (Valeriani et al., ; de Tommaso et al., ; Hüllemann et al., ; Hüllemann et al., ; Hüllemann et al., ). Therefore, reduced LEP‐habituation may be considered as abnormal central pain processing (Valeriani et al., ; de Tommaso et al., ; Hüllemann et al., ), which might enable the LEP‐habituation paradigm to be used as clinical tool for the detection of such.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral and central sensitization, which are thought to be major contributors to neuropathic pain conditions (Baron et al., ), seem to have opposing effects on habituation. Using the capsaicin model of peripheral and central sensitization we previously showed that LEP‐habituation was reduced due to peripheral sensitization processes (Hüllemann et al., ). In patients with migraine (Valeriani et al., ; de Tommaso et al., ), fibromyalgia (de Tommaso et al., ) and cardiac syndrome X (Valeriani et al., ) LEP‐habituation is also reduced.…”

Section: Introductionmentioning

confidence: 99%

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Reduced laser‐evoked potential habituation detects abnormal central pain processing in painful radiculopathy patients

Hüllemann

Manthey

Düsterhöft

et al. 2017

European Journal of Pain

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Peripheral sensitization reduces laser-evoked potential habituation

Cited by 24 publications

References 34 publications

Exploring the Mechanisms of Exercise-Induced Hypoalgesia Using Somatosensory and Laser Evoked Potentials

Exploring the Mechanisms of Exercise-Induced Hypoalgesia Using Somatosensory and Laser Evoked Potentials

ZNRD1‐AS and RP11‐819C21.1 long non‐coding RNA changes following painful laser stimulation correlate with laser‐evoked potential amplitude and habituation in healthy subjects: A pilot study

Reduced laser‐evoked potential habituation detects abnormal central pain processing in painful radiculopathy patients

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