Peripheral Retinal Neovascularization in Rheumatic Fever

Kelley, James S.; Randall, Harry G.

doi:10.1001/archopht.1979.01020010021005

Cited by 9 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified 1479 patients with IPD (median [IQR] age at onset, 10 [8-13] years in 1354 patients; 985 of 1426 [69.1%] female and 441 of 1426 [30.9%] male) were identified from 307 articles…”

Section: Resultsmentioning

confidence: 99%

Treatments and Outcomes Among Patients with Sydenham Chorea

Eyre,

Thomas,

Ferrarin

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceSydenham chorea is the most common acquired chorea of childhood worldwide; however, treatment is limited by a lack of high-quality evidence.ObjectivesTo evaluate historical changes in the clinical characteristics of Sydenham chorea and identify clinical and treatment factors at disease onset associated with chorea duration, relapsing disease course, and functional outcome.Data SourcesThe systematic search for this meta-analysis was conducted in PubMed, Embase, CINAHL, Cochrane Library, and LILACS databases and registers of clinical trials from inception to November 1, 2022 (search terms: [Sydenham OR Sydenham’s OR rheumatic OR minor] AND chorea).Study SelectionPublished articles that included patients with a final diagnosis of Sydenham chorea (in selected languages).Data Extraction and SynthesisThis study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline. Individual patient data on clinical characteristics, treatments, chorea duration, relapse, and final outcome were extracted. Data from patients in the modern era (1945 through 2022) were entered into multivariable models and stratified by corticosteroid duration for survival analysis of chorea duration.Main Outcomes and MeasuresThe planned study outcomes were chorea duration at onset, monophasic course (absence of relapse after ≥24 months), and functional outcome (poor: modified Rankin Scale score 2-6 or persisting chorea, psychiatric, or behavioral symptoms at final follow-up after ≥6 months; good: modified Rankin Scale score 0-1 and no chorea, psychiatric, or behavioral symptoms at final follow-up).ResultsIn total, 1479 patients were included (from 307 articles), 1325 since 1945 (median [IQR] age at onset, 10 [8-13] years; 875 of 1272 female [68.8%]). Immunotherapy was associated with shorter chorea duration (hazard ratio for chorea resolution, 1.51 [95% CI, 1.05-2.19]; P = .03). The median chorea duration in patients receiving 1 or more months of corticosteroids was 1.2 months (95% CI, 1.2-2.0) vs 2.8 months (95% CI, 2.0-3.0) for patients receiving none (P = .004). Treatment factors associated with monophasic disease course were antibiotics (odds ratio [OR] for relapse, 0.28 [95% CI, 0.09-0.85]; P = .02), corticosteroids (OR, 0.32 [95% CI, 0.15-0.67]; P = .003), and sodium valproate (OR, 0.33 [95% CI, 0.15-0.71]; P = .004). Patients receiving at least 1 month of corticosteroids had significantly lower odds of relapsing course (OR, 0.10 [95% CI, 0.04-0.25]; P &lt; .001). No treatment factor was associated with good functional outcome.Conclusions and RelevanceIn this meta-analysis of treatments and outcomes in patients with Sydenham chorea, immunotherapy, in particular corticosteroid treatment, was associated with faster resolution of chorea. Antibiotics, corticosteroids and sodium valproate were associated with a monophasic disease course. This synthesis of retrospective data should support the development of evidence-based treatment guidelines for patients with Sydenham chorea.

show abstract

Section: Resultsmentioning

confidence: 99%

Treatments and Outcomes Among Patients with Sydenham Chorea

Eyre,

Thomas,

Ferrarin

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

show abstract

“…Moreover, infarcted retina is not considered a source of angiogenic factor (3, 11, 1, 16). After branch retinal artery occlusion, preretinal and/or prepapillary neovascularization are very uncommon, but some cases have been reported (12,14,15,5,20,6,2) in various causative situations such as embolism, talc injection in drug abusers or arteriolitis. After branch retinal artery occlusion, preretinal and/or prepapillary neovascularization are very uncommon, but some cases have been reported (12,14,15,5,20,6,2) in various causative situations such as embolism, talc injection in drug abusers or arteriolitis.…”

Section: Discussionmentioning

confidence: 99%

Cases reported at the FAN club meeting, Bonn, November 1984

Gaudric

Coscas

1985

Int Ophthalmol

View full text Add to dashboard Cite

A 63 year-old man presented with an occlusion of the inferior temporal artery in his right eye, followed ten days later by an obstruction of the central retinal artery. Internal carotid stenosis was diagnosed and the patient underwent carotid endarterectomy. The retinal arterial circulation was restored except in the previously occluded inferotemporal artery. Nine months after the occlusion, preretinal new vessels began to grow at the border of the ischaemic area. Possible mechanisms governing the proliferation of new vessels after retinal arterial occlusion are discussed.

show abstract

Orthopedic surgery

1983

Arthritis & Rheumatism

View full text Add to dashboard Cite

Peripheral Retinal Neovascularization in Rheumatic Fever

Cited by 9 publications

References 6 publications

Treatments and Outcomes Among Patients with Sydenham Chorea

Treatments and Outcomes Among Patients with Sydenham Chorea

Cases reported at the FAN club meeting, Bonn, November 1984

Orthopedic surgery

Contact Info

Product

Resources

About