Peripheral retinal ischaemia, as evaluated by ultra-widefield fluorescein angiography, is associated with diabetic macular oedema

Wessel, Matthew M.; Nair, N. Sreekumaran; Aaker, Grant D.; Ehrlich, Joshua R.; D’Amico, Donald J.; Kiss, Szilárd

doi:10.1136/bjophthalmol-2011-300774

Cited by 184 publications

(119 citation statements)

References 14 publications

(6 reference statements)

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…Significant advances have been made in recent years with the release non-contact ultrawidefield imaging systems such as the Optos 200 Tx system (Optos plc., Scotland) [47][48][49]. This system uses an SLO with two wavelengths of laser light [green (532 nm) and red (633 nm)] to recreate a composite color image of the posterior segment.…”

Section: Ultrawidefield Imagingmentioning

confidence: 99%

See 1 more Smart Citation

Advances in Imaging in Age-Related Macular Degeneration

Keane

Sim

Sadda

2013

Curr Ophthalmol Rep

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is the leading cause of severe visual loss in people aged 50 years or older in the developed world. Advances in ocular imaging have driven many of the major breakthroughs in our understanding of the disease's pathogenesis, as well as many improvements in diagnosis and treatment. In this review, we describe the latest advances in ocular imaging applicable to patients with AMD. We begin with an overview of topographic imaging techniques, with an emphasis on emerging technologies such as ultrawidefield imaging, fundus autofluorescence, and adaptive optics. We next describe the latest advances in optical coherence tomography imaging, with an emphasis on novel image acquisition and analysis techniques of use for patients with AMD. In both cases, we describe the current state of the art for clinical imaging of patients with AMD and highlight new approaches likely to appear in clinical settings in the near future.

show abstract

Section: Ultrawidefield Imagingmentioning

confidence: 99%

“…For example, the use of filters allows ultrawidefield autofluorescence and angiographic imaging [48,50]. Ultrawidefield autofluorescence imaging may be of particular use for detection of degenerative changes of the peripheral retina in patients with AMD [51].…”

Section: Ultrawidefield Imagingmentioning

confidence: 99%

Advances in Imaging in Age-Related Macular Degeneration

Keane

Sim

Sadda

2013

Curr Ophthalmol Rep

View full text Add to dashboard Cite

show abstract

“…Peripheral Advancing the Detection and Management of Diabetic Retinopathy with Ultra-widefield Retinal Imaging ischemia, detected on UWF FA, has been strongly correlated with DME in treatment-naïve patients. 20 Other investigators have proposed a new ischemic index based on UWF findings. This work established the relationship between peripheral nonperfusion, severity of DR, and recalcitrant macular edema, while suggesting that areas of untreated peripheral nonperfusion may be the source of mediators of ischemia and disease progression.…”

Section: The Importance Of Examining the Periphery In Diabetic Retinomentioning

confidence: 99%

Advancing the Detection and Management of Diabetic Retinopathy with Ultra-widefield Retinal Imaging

Brown¹

2017

US Ophthalmic Review

View full text Add to dashboard Cite

T he incidence of diabetes in the US population has increased more than fourfold over the last several decades and a high proportion of these patients manifest diabetic eye disease, including diabetic retinopathy (DR) and diabetic macular edema (DME). Ultra-widefield (UWF) retinal imaging has emerged as a valuable tool in the evolving standard of care for DR, providing essential visualization of ischemia and related pathology across the retina, particularly in the periphery, where these signs may appear earliest but may not be detected by conventional fundus photography. Multimodal UWF imaging has helped correlate changes in the periphery with DR progression, providing important guidance for treatment planning and facilitating improved understanding of the underlying mechanisms of disease. Rapid capture, immediate retrieval and efficient sharing of UWF retinal images support a wide spectrum of care settings-including teleophthalmology programs-and facilitate patient education.

show abstract

“…12 The degree of peripheral nonperfusion has also been linked to increased diabetic macular edema (DME) in treatment-naïve patients with diabetic retinopathy, 13 as well as more recalcitrant DME, as evidenced by a greater number of macular photocoagulation treatments and less reduction in central macular thickness on optical coherence tomography (OCT). 14 …”

Section: Diabetic Retinopathymentioning

confidence: 99%

Wide-field Imaging of Retinal Diseases

Kim¹,

Moshfeghi²

2015

US Ophthalmic Review

View full text Add to dashboard Cite

125Retinal imaging serves as a critical adjunct to the diagnosis, monitoring, and treatment of numerous ocular diseases. Since the invention of the direct ophthalmoscope by Hermann von Helmholtz in 1851, techniques to visualize the fundus have grown exponentially both in number and sophistication. Notably, wide-field retinal imaging has taken center stage over the past 2 decades. Given its increasing popularity in research and clinical use, it is important to be aware of the different types of wide-field imaging currently available, as well as the clinical applications for, advantages, and limitations of widefield retinal imaging. This review article aims to highlight our current understanding of wide-field retinal imaging and provide an outlook for its future implications. Historical PerspectiveThe first fundus camera was developed by Frederick Dimmer at the turn of the 20th century. Dimmer was the first to incorporate fundus photography into an ophthalmic textbook, and he published the first photographic atlas in black-and-white. AbstractRetinal imaging serves as a critical adjunct to the diagnosis, monitoring, and treatment of numerous ocular diseases. In particular, wide-field retinal imaging is quickly moving to the forefront in imaging the posterior segment. While conventional fundus imaging captures 30 to 50° field of view in a single capture, significant advances have been made in the past 2 decades to increase the viewing angle, speed, and accuracy of fundus photography, such that a single-field capture is now up to 200°. Moreover, multiple imaging modalities, including color fundus photography, fluorescein angiography, and autofluorescence, are now available a single wide-field imaging platform. This breadth of functionality makes wide-field imaging especially useful in peripheral retinal vascular diseases, such as diabetic retinopathy, posterior uveitis, and retinopathy of prematurity. This review aims to provide a historical perspective on wide-field retinal imaging, highlight the imaging platforms currently available, discuss the advantages and disadvantages of wide-field versus conventional fundus imaging, summarize the current clinical applications of wide-field retinal imaging, and provide an outlook for its future implications. KeywordsWide-field imaging, ultra-wide-field imaging, retinal imaging, Optos, Heidelberg, fluorescein angiography, autofluorescence, diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity Disclosure: Esther Kim, MD, has no relevant conflicts of interest to declare. Andrew A Moshfeghi, MD, MBA, has been a consultant

show abstract

Peripheral retinal ischaemia, as evaluated by ultra-widefield fluorescein angiography, is associated with diabetic macular oedema

Cited by 184 publications

References 14 publications

Advances in Imaging in Age-Related Macular Degeneration

Advances in Imaging in Age-Related Macular Degeneration

Advancing the Detection and Management of Diabetic Retinopathy with Ultra-widefield Retinal Imaging

Wide-field Imaging of Retinal Diseases

Contact Info

Product

Resources

About