Peripheral pulmonary carcinoid tumors

Bonikos, Dionysis S.; Bensch, Klaus G.; Jamplis, Robert W.

doi:10.1002/1097-0142(197604)37:4<1977::aid-cncr2820370450>3.0.co;2-4

Cited by 79 publications

(26 citation statements)

References 50 publications

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“…It is of interest that the clearly defined subgroup of peripheral tumours documented by Salyer et al (1975) was characterised by spindle cell composition, anisocytosis, anisonucleosis, and overall disorganization of structure. Our finding of peripheral tumours which generally resembled their central counterparts is consonant with the work of other authors (Felton et al, 1953;Bonikos et al, 1976). It is possible that the unmixed pattern seen in three of the peripheral lesions may have been related to size as two of the tumours were less than 1 cm diameter.…”

Section: Discussionsupporting

confidence: 92%

Pulmonary carcinoid tumours: a comparative regional study.

Cooney¹,

Sweeney²,

Luke³

1979

J Clin Pathol

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SUMMARY Twenty-two pulmonary carcinoid tumours (18 central, 4 peripheral) were seen in this department over an 11-year period. The majority of the tumours displayed a mixed pattern on microscopic examination, and cell-nest formation was a prominent feature in sixteen. The findings are at variance with the results of a similar series reported from Japan and suggest that there is regional variation in the tumour pattern of pulmonary carcinoids. Various aspects of the histopathology are discussed, and a causal relationship between ossification of bronchial cartilage in these tumours and locally produced calcitonin is postulated.There have been numerous reports of series of pulmonary carcinoid tumours over the past 17 years.

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Section: Discussionsupporting

confidence: 92%

Pulmonary carcinoid tumours: a comparative regional study.

Cooney¹,

Sweeney²,

Luke³

1979

J Clin Pathol

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“…Although various histological types of lung tumors have been produced experimentally with Et2NNO (1,44), lung endocrine-like cells or their progenitors may be particularly sensitive to its carcinogenic effects (45). Taken together, the hyperplastic and progressive changes observed in NEBs in the present study may recapitulate the histopathological events occurring in the formation of peripheral pulmonary carcinoids (46) and bronchial carcinoid tumors and the progression to less differentiated lung carcinomas, such as small-cell carcinomas, which exhibit few cells with APUD characteristics. However, the relationship between the cellular alterations of the NEB cell population and tumor induction with Et2NNO in various segments of the airways of hamsters is as yet uncertain.…”

supporting

confidence: 74%

Lung endocrine-like cells in hamsters treated with diethylnitrosamine: alterations in vivo and in cell culture.

Linnoila¹,

Nettesheim²,

DiAugustine³

1981

Proc. Natl. Acad. Sci. U.S.A.

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Diethylnitrosamine is known to cause squamous cell carcinoma and adenocarcinoma of the lung in Syrian golden hamsters. Sections of lungs obtained from hamsters treated with the systemic carcinogen diethylnitrosamine showed a significant increase in the number of argyrophilic cells of neuroepithelial bodies. The hyperplastic response was retained at least 4 weeks after cessation of treatment. To examine whether these affected cells exhibited enhanced survival in vitro, lung cells were dissociated with Pronase and grown in culture. After 7 days, argyrophilia, dense-cored vesicles, and corticotropin-like immunoreactivity were observed in many of the cells derived from hamsters treated for 5 or 8 weeks. These findings suggest that the endocrinelike cells of neuroepithelial bodies are affected by diethylnitrosamine as evidenced by a numerical increase in vivo and by the properties exhibited by cells in vitro. The relationship of this diethylnitrosamine-induced reaction to bronchial carcinoid tumors or small-cell carcinoma of the lung remains to be established.There are experimental models for most human lung tumors but none for small-cell carcinoma or bronchial carcinoid tumors (1,2). This is discordant with the fact that small-cell carcinoma constitutes 17-29% of human lung tumors (3). The cytoplasmic dense-cored vesicles observed in small-cell carcinomas and in bronchial carcinoid tumors have caused some investigators to postulate that these tumors originate from lung endocrine-like (Kultschitzky) cells (4-9). In addition, many patients who have these tumors develop "ectopic hormone syndromes," especially the corticotropin (ACTH) syndrome (10).The finding that selected carcinogenic nitroso compounds such as diethylnitrosamine (Et2NNO) cess to water and food (NIH 31 diet). Twice a week, 3 mg of Et2NNO (Eastman) per hamster was injected subcutaneously. Hamsters, four per group, were treated for 5, 8, and 12 weeks with Et2NNO for cell culture experiments. After 8 weeks of treatment, groups of four hamsters were allowed to recover for 4 and 8 weeks. Histochemical and immunocytochemical studies were performed on lung sections from hamsters, 6-8 per group, after 4, 8, 12, and 16 weeks of exposure to Et2NNO. After the 8-, 12-, and 16-week treatment periods, groups offour hamsters were allowed to recover for 4 weeks. Control hamsters, two or three per group, received injections of saline and were sacrificed simultaneously with each group.Dissociation and Lung Cell Culture. Animals were anesthetized with methoxyflurane, the abdominal aorta was cut, and lungs were perfused through the pulmonary artery with Hepes/ balanced salt solution (GIBCO) until all lobes were blanched. A polypropylene cannula was inserted into the trachea, and the lungs were dissected free. A solution of0.1% Pronase P (Sigma) in Hepes/balanced salt solution was slowly infused (3.1 ml/hr) via the tracheal cannula through the lungs at 40C for 11 hr by using a Sage pump. The lungs were then inflated with 6 ml of fresh Pronase P solution and left ...

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“…The presence of a glandular or tubular pattern in the tumours is well recognised (Weiss and Ingram, 1961;Fu et al, 1974), and in a number of cases simple and complex gland lumina with bordering microvilli have been demonstrated on electron microscopy (Fu et al, 1974;Bell et al, 1975;Sonksen et al, 1976). More frequently, ultrastructural study of bronchial carcinoid tumours has revealed the presence of intercellular canaliculi with projecting microvilli (Elliott and Hardy, 1971;Renault and Verley, 1973;Patchefsky et al, 1974;Bell et al, 1975;Bonikos et al, 1976).…”

mentioning

confidence: 99%