Peripheral pulmonary adenoid cystic carcinoma with substantial submucosal extension to the proximal bronchus.

Inoue, Hiromichi; Iwashita, A; Kanegae, Hideaki; Higuchi, Kazue; Fujinaga, Yukihisa; Matsumoto, Isao

doi:10.1136/thx.46.2.147

Cited by 49 publications

(40 citation statements)

References 5 publications

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“…Primary lung ACC is relatively rare, accounting for 0.09-0.2% of all primary lung cancers (4,5), most of which arise in the central airways, such as the trachea and main bronchus. Peripheral lung ACC is very rare and represents approximately 10% of primary lung ACC (6). However, a series of primary peripheral lung ACC has not been described.…”

Section: Introductionmentioning

confidence: 99%

Primary Peripheral Adenoid Cystic Carcinoma of the Lung and Literature Comparison of Features

et al. 2007

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Adenoid cystic carcinoma arising from the peripheral lung is rare. Here, we describe adenoid cystic carcinoma that developed in the peripherally in S 9 of the right lower lobe of an 84-year-old woman. Cell blocks prepared from the bronchial wash specimens exhibited the cribriform formation. An immunohistochemical examination of the surgically resected tumor revealed positive thyroid transcription factor-1 and c-kit staining. Exons 9 and 11 of c-kit in tumor cells were not mutated. We compared the clinical features of this patient with those of 10 others described in the English-language literature.

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Section: Introductionmentioning

confidence: 99%

Primary Peripheral Adenoid Cystic Carcinoma of the Lung and Literature Comparison of Features

et al. 2007

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“…The "peripheral" variant of primary pulmonary ACC is quite rare. 1 Primary bronchial ACC requires complete resection, which often is accomplished through lobectomy or pneumonectomy, and the prognosis is usually very favorable. 9 Because of their usual submucosal location, most bronchial ACCs have an intact mucosa; therefore, with rare exceptions, 4,5 exfoliative procedures such as bronchial brushing or washing cytology are not always diagnostic for this neoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral ACC of the lung is uncommon and represents approximately 10% of the pulmonary ACC. 1 Radiographs of the chest are not sensitive enough for diagnosis of endobronchial ACC; however, they are useful in detecting ACC-associated atelectasis and post-obstructive pneumonia. Computed tomography (CT) of the chest and bronchoscopy are more sensitive tools for identifying endobronchial ACCs, and tissue biopsies or fine-needle aspiration (FNA) can be effectively performed under bronchoscopic guidance.…”

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confidence: 99%

“…Although ACC is the most common salivary gland-like tumor occurring in the lung, as a primary pulmonary neoplasm it is quite infrequent, comprising only 6% of bronchial adenocarcinomas and less then 0.2% of all primary pulmonary tumors. 1 Primary ACC of the lower respiratory tract comprises the "central" and "peripheral" variants. Centrally-located ACC usually arises in the lower trachea and the mainstem bronchi, where it produces endobronchial exophytic mass lesions and frequently results in bronchial obstruction, atelectasis, and post-obstructive pneumonia.…”

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confidence: 99%

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Primary pulmonary adenoid cystic carcinoma: Report of a case diagnosed by fine‐needle aspiration cytology

Qiu

Nampoothiri

Zaharopoulos

et al. 2003

Diagnostic Cytopathology

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Adenoid cystic carcinoma of the lower respiratory tract is an uncommon tumor that can arise in the mainstem bronchus and often presents as an endobronchial mass lesion causing bronchial obstruction with post obstructive atelectasis and pneumonia. Exfoliative cytology is seldom useful in the diagnosis of primary bronchial adenoid cystic carcinoma, because these neoplasms usually have a submucosal location with often intact mucosa. Since most endobronchial adenoid cystic carcinomas are endoscopically visible, bronchoscope-guided fine-needle aspiration constitutes an excellent approach to establish a pathologic diagnosis. The fine-needle aspiration cytology of primary pulmonary adenoid cystic carcinoma has been rarely described. We report a case of primary adenoid cystic carcinoma of the lung having characteristic cytologic features and correlate with computed tomography, bronchoscopic, and histological findings. Bronchoscope-guided aspiration cytology provided a conclusive diagnosis of adenoid cystic carcinoma, which was further corroborated by histology in the pneumonectomy specimen. Diagn. Cytopathol. 2004;30:51-56.

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“…Primary ACC arises in the central airways, such as the trachea and main bronchus. Meanwhile, peripheral lung ACC is very rare, representing approximately 10% of cases of primary lung ACC [4]. We herein report a case of primary ACC of the peripheral lungs treated with video-assisted thoracoscopic surgery (VATS).…”

Section: Introductionmentioning

confidence: 99%

Primary Adenoid Cystic Carcinoma of the Peripheral Lungs

Shinohara

Hanagiri

Takenaka

et al. 2015

J UOEH

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: We herein report a very rare case of adenoid cystic carcinoma of the peripheral lungs. A 77-year-old female visited a family physician for aortitis syndrome, diabetes mellitus and hyperlipidemia. A follow-up chest computed tomography scan for aortitis syndrome revealed a nodule in the middle lobe of the right lung. Although a transbronchial lung biopsy was attempted, a definitive diagnosis could not be made. Because the possibility of lung malignancy could not be ruled out, thoracoscopic wedge resection of the middle lobe was performed. The intraoperative pathological diagnosis revealed carcinoma of the lungs and we performed middle lobectomy under complete video-assisted thoracoscopic surgery. A histopathological examination demonstrated an adenoid cystic carcinoma with a characteristic cribriform structure.

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Peripheral pulmonary adenoid cystic carcinoma with substantial submucosal extension to the proximal bronchus.

Abstract: Histological appearance of the resected lung specimen: adenoid cystic carcinoma is covered with bronchial mucosa, infiltrating the bronchial wall.

Cited by 49 publications

References 5 publications

Primary Peripheral Adenoid Cystic Carcinoma of the Lung and Literature Comparison of Features

Primary Peripheral Adenoid Cystic Carcinoma of the Lung and Literature Comparison of Features

Primary pulmonary adenoid cystic carcinoma: Report of a case diagnosed by fine‐needle aspiration cytology

Primary Adenoid Cystic Carcinoma of the Peripheral Lungs

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