Peripheral Primitive Neuroectodermal Tumor of the Ovary Confirmed by CD99 Immunostaining, Karyotypic Analysis, and RT-PCR for EWS/FLI-1 Chimeric mRNA

Kawauchi, Shigeto; Fukuda, Toshiro; Miyamoto, Shingo; Yoshioka, Jun-Ichi; Shirahama, Syuya; Saito, Toshiaki; Tsuji, Naoki

doi:10.1097/00000478-199811000-00013

Cited by 92 publications

(32 citation statements)

References 18 publications

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“…No cells react with antibodies for cytokeratin, desmin, chromogranin or inhibin [11,12]. Molecular genetic analysis can be an adjunct to the diagnosis of PNET of the ovary as it shows Ewing's sacroma gene/Friend leukemia virus integration 1 gene (EWS/FLI-1) fusion gene transcript type 2 by reverse transcriptase-polymerase chain reaction and EWS gene rearrangement by fluorescence in situ hybridization [13,14]. The results of comparative genomic hybridization revealed multiple chromosomal abnormalities in PNET of the ovary.…”

Section: Discussionmentioning

confidence: 99%

A case of primitive neuroectodermal tumor of the ovary

Kuk

Yoon

Kim

et al. 2012

Korean J Obstet Gynecol

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Peripheral primitive neuroectodermal tumor (PNET) is a small round tumor belonging to the PNET/Ewing's sarcoma family classified based on location in the body. There have been a small number of case reports of PNET arising in the ovary. We present extremely rare case of PNET of the ovary occurring in a 32-year-old pregnant woman, which was detected during her second Cesarean section. She had a past history of oophorectomy due to a huge mature solid teratoma in left ovary during her first Cesarean section. She got the operation of right salpingoophorectomy during the second Cesarean section at local gynecologic clinic and referred to our institute. Magnetic resonance imaging and positron emission tomography revealed the PNET was metastased to the peritoneum and the lymph nodes. We had persecuted vincristine, doxorubicin, cyclophosphamide, and etoposide/ifosfamide 8 cycles. There has been no evidence of local tumor recurrence and metastasis after the chemotherapy until now.

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Section: Discussionmentioning

confidence: 99%

A case of primitive neuroectodermal tumor of the ovary

Kuk

Yoon

Kim

et al. 2012

Korean J Obstet Gynecol

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“…It refers to immature primitive malignant tumour, expressing the MIC2 gene, proved by the marker CD99. 15,31 Homer-Wright (H-W) rosettes are often found. 32 Cells seen on electron microscopic examination are characterized by small amounts of mitochondria and glycogen particles without neurosecretory granules.…”

Section: Discussionmentioning

confidence: 99%

“…ovary,14,15 cervix,5,16,17 uterus,[18][19][20] broad ligament of the body of the uterus, 21 vulva, vagina and septum rectovaginalis, 22-26 thoracic region (Askin's tumour), 27 extremities, 28,29 etc. Routine use of immunohistochemistry and electronic microscopy facilitate diagnosis of peripheral PNET, so more and more cases are published.…”

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confidence: 99%

Retroperitoneal primitive neuroectodermal tumour (PNET). A case report and review of the literature

Marinova

2009

Reports of Practical Oncology & Radiotherapy

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reports of practical oncology and radiotherapy 1 4 ( 2 0 1 0 ) 221-224 a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : h t t p : / / w w w . r p o r . e u / Primitive neuroectodermal tumour Neuroectodermal tumour External beam radiotherapy Multimodality treatment Radiosensitivity a b s t r a c t Purpose: We report a clinical case and present a brief review of the literature of peripheral primitive neuroectodermal tumour (PNET) as a rare disease. We discuss the difficult clinical and pathological diagnosis and the multidisciplinary approach to treatment of PNET. We debate radiosensitivity of extracranial recurrent retroperitoneal PNET.Methods and materials: External beam radiation therapy was applied for a non-resectable local recurrence of retroperitoneal PNET in a 74-year-old woman. There were no distant metastases and our patient has refused chemotherapy.Results: Local tumour control (LTC) was achieved after administration of a total dose of 60 Gy in 30 fractions by external beam 60 Cobalt radiotherapy.Conclusions: PNET is an aggressive malignant tumour infiltrating lymphatics and metastasizing haematogenously. It requires a multimodality treatment. Late local recurrence of extracranial retroperitoneal PNET has shown high radiosensitivity, so local tumour irradiation could be a radical treatment even in non-resectable cases.

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“…15 Silverman and Joshi 13 reported the fine-needle aspiration (FNA) features which include hypercellular smears with numerous small cells, with finely vacuolated or wispy unipolar-type cytoplasm and prominent nuclear molding. Distinction from IOT while challenging is not impossible as PNETs only rarely contain rosettes and do not contain neuropil or endo/ectodermal elements.…”

Section: Discussionmentioning

confidence: 99%

Imprint cytology of high‐grade immature ovarian teratoma: A case report, literature review, and distinction from other ovarian small round cell tumors

Ramalingam

Teague

Reid-Nicholson

2008

Diagnostic Cytopathology

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Immature ovarian teratoma (IOT) is a rare and aggressive malignant neoplasm characterized by immature neural tissue. The cytomorphologic features have only rarely been described. We herein describe an additional case and review the literature regarding this entity. To the best of our knowledge, this is the first reported case with imprint cytology. A 35-year-old woman presented with a pelvic mass which was resected and sent for frozen section evaluation. Imprint smears and frozen section of the mass were diagnostic of IOT. IOT has diagnostic cytologic features which show complete concordance with histology. Differential diagnoses include other small round cell neoplasms such as ovarian neuroblastoma, small cell carcinoma of hypercalcemic type, primitive neuroectodermal tumor, Wilm's tumor, desmoplastic small round cell tumor, and Non-Hodgkin lymphoma. Distinguishing IOT from these tumors can be challenging however if diligent morphologic study and/or ancillary studies are performed accurate diagnosis is possible.

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Peripheral Primitive Neuroectodermal Tumor of the Ovary Confirmed by CD99 Immunostaining, Karyotypic Analysis, and RT-PCR for EWS/FLI-1 Chimeric mRNA

Cited by 92 publications

References 18 publications

A case of primitive neuroectodermal tumor of the ovary

A case of primitive neuroectodermal tumor of the ovary

Retroperitoneal primitive neuroectodermal tumour (PNET). A case report and review of the literature

Imprint cytology of high‐grade immature ovarian teratoma: A case report, literature review, and distinction from other ovarian small round cell tumors

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