Abstract:Primitive neuroectodermal tumor is a member of malignant small round cell tumors. These tumors especially originate from the central and autonomous nervous system. However, these tumors may be originated from peripheral tissues and are called peripheral primitive neuroectodermal tumor. A 14-year-old girl attended to the Ear Nose Throat Clinic with the complaint of progressive painless swelling mass for 2 months on the right side of the face. Neck magnetic resonance imaging showed 3.5 × 2.5 × 2-cm isointense ma… Show more
“…PNETs are most commonly encountered in pediatric patients with diverse clinical manifestations, and are classified into three groups based on the tissue of origin: Central nervous system (CNS) PNETs, neuroblastoma and peripheral PNEs (pPNETs) derived from tissues outside the CNS and autonomic nervous system (1). pPNETs occur predominantly during infancy or childhood, and are located in the abdomen (2,3), thoracopulmonary region (4,5) and, rarely, in the head and neck region (6). pPNETs are extremely rare in adults, particularly in the hip muscles with bone metastasis.…”
Abstract. Peripheral primitive neuroectodermal tumors (pPNETs) are a group of aggressive neoplasms that are most commonly encountered in pediatric patients and may be located in the abdomen, pelvis, thoracopulmonary region and, rarely, in the head and neck region. pPNETs in adults are extremely rare. The present study reports a case of pPNET located in the hip muscles with bone metastasis. The patient was a 44-year-old woman who complained of progressive pain and swelling with a mass near the left hip. Computed tomography (CT) and enhanced CT revealed a soft tissue mass lesion in the hip muscle group measuring 4.3x4.3x4.4 cm. The lesion was ill-defined, heterogeneous, exhibiting mild post-contrast enhancement. There was a large number of bent neovessels and several branches from the left internal iliac artery and deep femoral artery on enhanced CT scan. Triple-phase dynamic imaging with integrin α v β 3 -targeted 99m Tc-3P-RGD 2 as the radiotracer revealed increased blood perfusion and radiotracer aggregation in the large, ill-defined, heterogeneous, hypodense mass and adjacent bone. The patient was suspected of having pPNET with bone metastasis, which was confirmed by histological examination of a sample obtained by needle aspiration. Due to the high blood perfusion of primary pPNETs and high RGD uptake by the primary and metastatic lesions, chemoembolization and anti-angiogenic therapy were considered to be the optimal therapeutic choice. This also suggested that 177 Lu-labeled RGD has great potential for the targeted treatment of pPNETs with multiple metastases.
“…PNETs are most commonly encountered in pediatric patients with diverse clinical manifestations, and are classified into three groups based on the tissue of origin: Central nervous system (CNS) PNETs, neuroblastoma and peripheral PNEs (pPNETs) derived from tissues outside the CNS and autonomic nervous system (1). pPNETs occur predominantly during infancy or childhood, and are located in the abdomen (2,3), thoracopulmonary region (4,5) and, rarely, in the head and neck region (6). pPNETs are extremely rare in adults, particularly in the hip muscles with bone metastasis.…”
Abstract. Peripheral primitive neuroectodermal tumors (pPNETs) are a group of aggressive neoplasms that are most commonly encountered in pediatric patients and may be located in the abdomen, pelvis, thoracopulmonary region and, rarely, in the head and neck region. pPNETs in adults are extremely rare. The present study reports a case of pPNET located in the hip muscles with bone metastasis. The patient was a 44-year-old woman who complained of progressive pain and swelling with a mass near the left hip. Computed tomography (CT) and enhanced CT revealed a soft tissue mass lesion in the hip muscle group measuring 4.3x4.3x4.4 cm. The lesion was ill-defined, heterogeneous, exhibiting mild post-contrast enhancement. There was a large number of bent neovessels and several branches from the left internal iliac artery and deep femoral artery on enhanced CT scan. Triple-phase dynamic imaging with integrin α v β 3 -targeted 99m Tc-3P-RGD 2 as the radiotracer revealed increased blood perfusion and radiotracer aggregation in the large, ill-defined, heterogeneous, hypodense mass and adjacent bone. The patient was suspected of having pPNET with bone metastasis, which was confirmed by histological examination of a sample obtained by needle aspiration. Due to the high blood perfusion of primary pPNETs and high RGD uptake by the primary and metastatic lesions, chemoembolization and anti-angiogenic therapy were considered to be the optimal therapeutic choice. This also suggested that 177 Lu-labeled RGD has great potential for the targeted treatment of pPNETs with multiple metastases.
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