Peripheral polyneuropathy after acute methanol poisoning: Six-year prospective cohort study

Kotikova, Katerina; Klepiš, Petr; Ridzoň, Petr; Hlusicka, Jiri; Navrátil, Tomáš; Rulíšek, Jan; Zak, Ivan; Zakharov, Sergey

doi:10.1016/j.neuro.2020.04.010

Cited by 5 publications

(3 citation statements)

References 64 publications

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“…However, the presence of methanol increased the level of toxicity and the risk of not being able to administer e-C, m-C, and l-C at high concentrations. Methanol is the simplest of the alcohols and its chemical formula is CH 3 OH; it is very volatile, extremely flammable, and toxic, inducing depression of the central nervous system and damage to the optic nerve and retina [39]. Ethanol (CH 3 CH 2 OH) is very similar to methanol but contains one carbon and two other hydrogen atoms in its molecule.…”

Section: Discussionmentioning

confidence: 99%

Cladodes of Opuntia ficus-indica (L.) Mill. Possess Important Beneficial Properties Dependent on Their Different Stages of Maturity

Maiuolo,

Nucera,

Serra

et al. 2024

Plants

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Opuntia ficus-indica (L.) Mill. belongs to the Cactaceae family and the genus Opuntia; it is a succulent plant that adapts to extreme climatic conditions. The aerial part of the plant consists of the cladodes, morphological changes of branches that appear green, are covered with thorns, and are essential to reduce excessive perspiration of water. The composition of cladodes is very varied, and the main constituents are water, fibers, polysaccharides, proteins, fatty acids, vitamins, sterols, minerals, and polyphenols. Polyphenols are responsible for many beneficial activities for human health, such as antioxidant, anti-inflammatory, anticancer, and nutritional properties. The purpose of this manuscript was to compare the properties of cladodes belonging to the same plant but with different stages of maturity. Relative extracts were tested both in vitro and on a cell line and antioxidant and anti-apoptotic properties were found. The antioxidant activity was tested by the Oxygen Radical Absorbance Capacity (ORAC) test, the 1,1-diphenyl-2-picrylhydrazil (DPPH) test, and the measurement of cellular accumulation of reactive oxygen species (ROS). Anti-apoptotic activity was evaluated by the annexin/PI assay and measurement of caspases 9 and 3 expression. The results obtained showed that the extracts considered possess antioxidant and anti-apoptotic properties. However, the different stages of maturity of cladodes are essential for the performance of both functions. In addition, important variations were made in the dissolution of the extracts that brought greater safety in their use. In conclusion, this manuscript provides further information on cladodes of Opuntia ficus-indica, which can be used as adjuvants in many human pathologies.

show abstract

Section: Discussionmentioning

confidence: 99%

Cladodes of Opuntia ficus-indica (L.) Mill. Possess Important Beneficial Properties Dependent on Their Different Stages of Maturity

Maiuolo,

Nucera,

Serra

et al. 2024

Plants

View full text Add to dashboard Cite

show abstract

“…However, the presence of methanol increased the level of toxicity and the risk of not being able to administer e-C, m-C, and l-C at high concentrations. Methanol is the simplest of alcohols and its chemical formula is CH3OH; it is very volatile, extremely flammable, and toxic inducing depression of the central nervous system and damage to the optic nerve and retina [24]. Ethanol (CH3CH2OH) is very similar to methanol but contains one carbon and two other hydrogen atoms in its molecule.…”

Section: Discussionmentioning

confidence: 99%

Cladodes of <em>Opuntia ficus-indica</em> (L.) Mill. Possess Important Beneficial Properties Dependent on Their Different Stages of Maturity

Maiuolo,

Nucera,

Serra

et al. 2024

Preprint

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Opuntia ficus-indica (L.) Mill. belongs to the Cactaceae family and the genus Opuntia; it is a succulent plant that adapts to extreme climatic conditions. The aerial part of the plant consists of the cladodes, morphological changes of branches that appear green, are covered with thorns, and are essential to reduce excessive perspiration of water. The composition of cladodes is very varied, and the main constituents are water, fibers, polysaccharides, proteins, fatty acids, vitamins, sterols, minerals, and polyphenols. Polyphenols are responsible for many beneficial activities for human health, such as antioxidant, anti-inflammatory, antitumor, and nutritional properties. The purpose of this manuscript was to compare the properties of cladodes belonging to the same plant but with different stages of maturity. Relative extracts were tested both in vitro and on a cell line and antioxidant and anti-apoptotic properties were found. The antioxidant activity was tested by the ORAC test, the DPPH test, and the measurement of cellular accumulation of ROS. Anti-apoptotic activity was evaluated by the annexin/PI assay and measurement of caspases 9 and 3 expression. The results obtained have shown that the extracts considered possess antioxidant and anti-apoptotic properties. However, the different stages of maturity of cladodes are essential for the performance of both functions. In addition, important variations have been made in the dissolution of extracts that have brought greater safety in their use. In conclusion, this manuscript provides further information on cladodes of Opuntia ficus-indica, which can be used as adjuvants in many human pathologies.

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“…AMP is available to lead to severe damage to the central nervous system (CNS) [ 30 ]. Momentous progress has been made in AMP treatment, but the mortality rate is still increasing.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6

Zhou

Zhang

et al. 2022

Bioengineered

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Microglia activation-stimulated neuroinflammation exerts functionally in neurodegenerative diseases like brain injury. Acute methanol poisoning (AMP) is a crucial cause of death and morbidity that possibly leads to neuroinflammation. Studies have manifested that miRNAs can modulate microglia activation to mediate neuroinflammation. Nevertheless, the role of miR-124 in AMP-stimulated neuroinflammation is uncertain. This research was to explore the action of miR-124 in AMP-stimulated neuroinflammation and its molecular mechanism. The study findings indicated that AMP accelerated microglia activation and stimulated inflammation and oxidative stress in brain tissue of rats. MiR-124 expression was lowered in AMP rats, while KLF6 expression was elevated. Elevated miR-124 or repressed KLF6 increased the number of CD206 + cells and decreased the number of CD68 + cells, as well as restrained inflammation and NF-κB phosphorylation and induced superoxide dismutase, Nrf2/HO-1, and M2 polarization. MiR-124 modulated microglia activation via targeting KLF6. AMP repressed neuronal viability and enhanced neuronal apoptosis. Suppression of miR-124 further promoted AMP-induced damage to neurons, while inhibition of KLF6 turned around this phenomenon. Anyway, our study demonstrated that miR-124 accelerates M2 polarization via targeting KLF6 to ameliorate AMP-stimulated neuronal damage.

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Peripheral polyneuropathy after acute methanol poisoning: Six-year prospective cohort study

Cited by 5 publications

References 64 publications

Cladodes of Opuntia ficus-indica (L.) Mill. Possess Important Beneficial Properties Dependent on Their Different Stages of Maturity

Cladodes of Opuntia ficus-indica (L.) Mill. Possess Important Beneficial Properties Dependent on Their Different Stages of Maturity

Cladodes of <em>Opuntia ficus-indica</em> (L.) Mill. Possess Important Beneficial Properties Dependent on Their Different Stages of Maturity

MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6

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