Peripheral p-chloroamphetamine is an unsuitable probe for investigation of central serotoninergic control on renal renin secretion in the rat

Ikonomov, Ognian C.; Shisheva, Assia; Stoynev, Alexander; Kurtev, I

doi:10.1016/0031-9384(91)90339-p

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…There are 6 genes for the regulation of circadian rhythms. A pathogenetic relationship was revealed between variations in melatonin secretion and development of internal diseases [8].…”

Section: Resultsmentioning

confidence: 99%

Biorhythms of activities of liver and blood dehydrogenases and changes in body weight of the rats feeding normal diet or excess of sugar substitutes

Petrovich¹,

Volozhin²,

Zubtsov³

et al. 2007

Bull Exp Biol Med

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Biorhythms with higher levels of activity of sorbitol dehydrogenase and lactate dehydrogenase in blood plasma, specific activity of sorbitol dehydrogenase, lactate dehydrogenase, and malate dehydrogenase in the liver, and body weight of rats were more pronounced in the spring-summer period than in the autumn-winter period. These specific features were revealed in animals feeding a normal diet or food with 54 and 27% sugar substitute sorbitol. However, specific activity of glucose-6-phosphate dehydrogenase in the liver was higher in the autumn-winter period. Activity of sorbitol dehydrogenase in blood plasma increased by tens of times due to induction of sorbitol synthesis (substrate) in the liver. Sugar substitute xylitol is structurally similar to sorbitol, but is not the substrate for sorbitol dehydrogenase. However, the effect of xylitol on activities of lactate dehydrogenase, malate dehydrogenase, and glucose-6-phosphate dehydrogenase in the spring-summer period was similar to that of sorbitol.

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“…There are 6 genes for the regulation of circadian rhythms. A pathogenetic relationship was revealed between variations in melatonin secretion and development of internal diseases [8].…”

Section: Resultsmentioning

confidence: 99%

Biorhythms of activities of liver and blood dehydrogenases and changes in body weight of the rats feeding normal diet or excess of sugar substitutes

Petrovich¹,

Volozhin²,

Zubtsov³

et al. 2007

Bull Exp Biol Med

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show abstract

“…Centrally administered 5-HT has been shown to elevate BP and increase Na+ excretion [35,36]. Centrally admin istered p-chloroamphetamine has also been shown to raise BP and stimulate Na+ excretion [35], Other studies [37] suggested that peripherally injected /»-chloroamphetamine produces increased urine excretion prior to the in crease in renin secretion. Collectively, these studies sug gest that p-chloroamphetamine's mechanism of action may be complicated by either direct or indirect action on the kidney, and that the increase in renin secretion may occur secondarily to elevated Na+ excretion.…”

Section: Thementioning

confidence: 99%

Central Stimulation of Renin Secretion through Serotonergic, Noncardiovascular Mechanisms

et al. 1994

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The aims of the study were to determine; (1) whether activation of serotonin (5-HT) receptors in the brain increases renin secretion, and (2) whether the hypertensive effects of a 5-HT agonist and 5-HT releaser obscure their ability to stimulate renin release. Various drugs that increase serotonergic neurotransmission can activate the secretion of renin from the kidneys. Many of these drugs can also elevate blood pressure. Changes in blood pressure can alter renin secretion by activating renal baroreceptor mechanisms, so that a decrease in perfusion pressure will increase renin secretion and vice versa. To address the first objective, the 5-HT agonist RU 24969 (0, 10, 100 and 200 µg/kg) and the 5-HT releaser p-chloroamphetamine (0, 50, 500 and 1,000 µg/ kg) were injected intracerebroventricularly (ICV) at doses lower than those that are peripherally effective. ICV injection of RU 24969 dose-dependently increased plasma levels of renin. ICV injection of the 5-HT_2A/5-HT_2C antagonist LY53857 (50 µg/kg) inhibited the renin response to peripherally injected RU 24969 (0, 1, 5 and 10 mg/kg i.p.), suggesting that 5-HT_2A/5-HT_2C receptors in the brain mediate the effect of peripherally injected RU 24969 on renin secretion. In contrast, ICV injection of p-chloroamphetamine decreased renin secretion. To determine whether hypertensive actions could account for the differences between RU 24969 and p-chloroamphetamine, we measured the effects of both p-chloroamphetamine and RU 24969 on blood pressure and heart rate. ICV injection of p-chloroamphetamine (1,000 µg/kg) produced a large rise of 44 mm Hg at 2 min and 25 mm Hg at 5 min after injection, while ICV injection of RU 24969 (200 µg/kg) caused a slower and smaller blood pressure elevation of 18 mm Hg at 5 min after injection. To determine whether the hypertensive effects of both RU 24969 and p-chloroamphetamine could mask their effects on renin secretion, rats were pretreated with the α₁ antagonist prazosin. Administration of prazosin (1 mg/kg s.c), which prevents the hypertensive effects of p-chloroamphetamine, exposed a stimulatory effect of ICV-injected p-chloroamphetamine (500 µg/kg) on renin secretion and potentiated the effect of RU 24969 (5 mg/kg i.p.) on renin release. In conclusion, these data suggest that both RU 24969 and p-chloroamphetamine increase renin secretion through central 5-HT receptors, and that these effects are partially obscured by their hypertensive actions.

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A serotonin neurotoxin attenuates the phase-shifting effects of triazolam on the circadian clock in hamsters

1995

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Peripheral p-chloroamphetamine is an unsuitable probe for investigation of central serotoninergic control on renal renin secretion in the rat

Cited by 3 publications

References 27 publications

Biorhythms of activities of liver and blood dehydrogenases and changes in body weight of the rats feeding normal diet or excess of sugar substitutes

Biorhythms of activities of liver and blood dehydrogenases and changes in body weight of the rats feeding normal diet or excess of sugar substitutes

Central Stimulation of Renin Secretion through Serotonergic, Noncardiovascular Mechanisms

A serotonin neurotoxin attenuates the phase-shifting effects of triazolam on the circadian clock in hamsters

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