Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment

Zhang, Lin; Li, Dongna; Yi, Pengrong; Shi, Jiangwei; Guo, Mengqing; Yin, Qingsheng; Liu, Dingbin; Zhuang, Pengwei; Zhang, Yanjun

doi:10.1016/j.apsb.2023.03.018

Cited by 2 publications

(2 citation statements)

References 103 publications

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“…In the obese brain, these molecules are enriched in the hippocampus and hypothalamus, likely contributing to the rewiring of higher-order processing and satiety regulation, respectively [ 22 ]. Diabetes mellitus induces abnormal expression of exosome miRNA in multiple peripheral tissues with an altered central exosome absorption [ 23 ]. One possibility is that there is an increase in exosome miRNA flux into the brain that leads to a loss of aquaporin-4 expression and redistribution in perivascular astrocyte endfeet, resulting in glymphatic dysfunction and cognitive decline [ 23 ].…”

Section: Remodeling Of Adipose Tissue Shapes Cognitive Functionmentioning

confidence: 99%

“…Diabetes mellitus induces abnormal expression of exosome miRNA in multiple peripheral tissues with an altered central exosome absorption [ 23 ]. One possibility is that there is an increase in exosome miRNA flux into the brain that leads to a loss of aquaporin-4 expression and redistribution in perivascular astrocyte endfeet, resulting in glymphatic dysfunction and cognitive decline [ 23 ]. Downregulation of these extracellular vesicles ameliorates cognitive impairments, thereby making them novel targets for pharmaceutical intervention to treat metabolically induced cognitive dysfunction.…”

Section: Remodeling Of Adipose Tissue Shapes Cognitive Functionmentioning

confidence: 99%

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Neuro-Adipokine Crosstalk in Alzheimer’s Disease

Chen,

Schneeberger

2024

IJMS

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The connection between body weight alterations and Alzheimer’s disease highlights the intricate relationship between the brain and adipose tissue in the context of neurological disorders. During midlife, weight gain increases the risk of cognitive decline and dementia, whereas in late life, weight gain becomes a protective factor. Despite their substantial impact on metabolism, the role of adipokines in the transition from healthy aging to neurological disorders remains largely unexplored. We aim to investigate how the adipose tissue milieu and the secreted adipokines are involved in the transition between biological and pathological aging, highlighting the bidirectional relationship between the brain and systemic metabolism. Understanding the function of these adipokines will allow us to identify biomarkers for early detection of Alzheimer’s disease and uncover novel therapeutic options.

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Section: Remodeling Of Adipose Tissue Shapes Cognitive Functionmentioning

confidence: 99%

Section: Remodeling Of Adipose Tissue Shapes Cognitive Functionmentioning

confidence: 99%

Neuro-Adipokine Crosstalk in Alzheimer’s Disease

Chen,

Schneeberger

2024

IJMS

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Impact of insulin resistance on mild cognitive impairment in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease

Zhang,

Fareeduddin Mohammed Farooqui,

Zhu

et al. 2023

Diabetol Metab Syndr

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Aims Insulin resistance (IR) is a pivotal factor in the pathogenesis of type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Nevertheless, the impact of IR on cognitive dysfunction in T2DM patients with NAFLD remains inadequately understood. We aim to investigate the effect of IR on mild cognitive impairment (MCI) in T2DM individuals with NAFLD. Materials and methods 143 T2DM individuals were categorized into Non-MCI and MCI groups, as well as Non-NAFLD and NAFLD groups. Clinical parameters and cognitive preference test outcomes were compared. Correlation and regression analyses were executed to explore the interconnections between IR and cognitive details across all T2DM patients, as well as within the subgroup of individuals with NAFLD. Results In comparison to the Non-MCI group, the MCI group displayed elevated HOMA-IR levels. Similarly, the NAFLD group exhibited higher HOMA-IR levels compared to the Non-NAFLD group. Additionally, a higher prevalence of MCI was observed in the NAFLD group as opposed to the Non-NAFLD group. Notably, HOMA-IR levels were correlated with Verbal Fluency Test (VFT) and Trail Making Test-B (TMTB) scores, both related to executive functions. Elevated HOMA-IR emerged as a risk factor for MCI in the all patients. Intriguingly, increased HOMA-IR not only correlated with TMTB scores but also demonstrated an influence on TMTA scores, reflecting information processing speed function in patients with NAFLD. Conclusion IR emerges as a contributory factor to cognitive dysfunction in T2DM patients. Furthermore, it appears to underlie impaired executive function and information processing speed function in T2DM individuals with NAFLD.

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Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment

Cited by 2 publications

References 103 publications

Neuro-Adipokine Crosstalk in Alzheimer’s Disease

Neuro-Adipokine Crosstalk in Alzheimer’s Disease

Impact of insulin resistance on mild cognitive impairment in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease

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