Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity

Abstract

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Association of Optical Coherence Tomography–Measured Fibrovascular Ridge Thickness and Clinical Disease Stage in Retinopathy of Prematurity

“…Previous work using an artificial intelligence–based vascular severity score compared with clinical diagnosis has suggested that changes in vascular severity (dilation and tortuosity) are associated with changes in the stage and/or extent of disease. Using OCT to visualize the retinal periphery, it is possible to observe clinical progression of so-called popcorn retinal neovascularization, which occurs posterior to the ridge, as well as the coalescing into the typical stage 3 lesion, the development of retinoschisis and tractional retinal detachment, and the relationship between those features and vascular severity in the posterior retina . In addition, OCT may be useful for monitoring and characterizing patterns of disease regression following both spontaneous resolution of disease and treatment-induced disease regression …”

“…However, recent advances in swept-source handheld OCT devices have been promising . Previous work has provided qualitative evidence that OCT B-scans reveal progressive changes in the retinal topography associated with increasing disease stage …”

“…[5][6][7][8] Previous work has provided qualitative evidence that OCT B-scans reveal progressive changes in the retinal topography associated with increasing disease stage. [9][10][11][12] There are several approaches to visualize the retinal periphery, including the use of scleral depression and optical design changes that improve the FOV at the expense of image resolution. 10,11 In collaboration with the Center for Ophthalmic Optics and Lasers (COOL) Lab at Oregon Health & University, we recently described a portable ultra-widefield sweptsource , and OCT device with a handheld probe 13,14 that can reliably obtain views of the peripheral stage in ROP.…”

Widefield Optical Coherence Tomography in Pediatric Retina: A Case Series of Intraoperative Applications Using a Prototype Handheld Device

“…Most of the early work using OCT work has focused on macular manifestations of ROP, such as the presence of macular edema, vitreous opacities, and the presence of retinoschisis posterior to the ridge ( 3 , 4 , 30 ). Widefield OCT has demonstrated the potential to provide real-time en face visualization, objective assessment of the peripheral stage, longitudinal monitoring of disease progression and regression, and detection of early vitreoretinal interface abnormalities ( 13 , 14 , 31 ).…”

“…The 105° FOV system has potential to provide objective diagnosis in pediatric retinal diseases with predominantly extramacular pathology, like ROP, and contribute to new insight in these disease processes. We recently described our experience using these devices for ROP screening in the neonatal intensive care unit (NICU) in awake infants ( 13 , 14 ). Here, we present a review of the potential clinical benefits and applications of widefield (WF) and ultra-widefield (UWF) handheld OCT in pediatric retina patients undergoing examinations under anesthesia (EUA) for a variety of conditions.…”