Peripheral neuropeptide Y differentially influences adipogenesis and lipolysis in chicks from lines selected for low or high body weight

Liu, Lingbin; Wang, Guoqing; Shipp, Steven L.; Siegel, P. B.; Cline, Mark A.; Gilbert, Elizabeth R.

doi:10.1016/j.cbpa.2017.08.001

Cited by 14 publications

(11 citation statements)

References 46 publications

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“…Six 30-week-old birds were randomly selected from among the DX and LH egg-laying hens and then euthanized by cervical dislocation to collect the following ovarian tissues: stroma with cortical follicles < 1 mm in diameter (STR), prehierarchical follicles including white follicles (WF, 1–4 mm in diameter), yellowish follicles (YF, 4–8 mm in diameter) and small yellow follicles (SYF, 8–12 mm in diameter), and hierarchical follicles F1–F6 (with the largest denoted as F1, the second largest as F2, etc.). All samples were submerged in RNAlater (Invitrogen, Carlsbad, CA) overnight at 4°C and then stored at −80°C [ 39 ].…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits

Liu

Cui

Xiao

et al. 2018

BioMed Research International

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The aim of the study was to investigate GDF9 gene polymorphisms and their association with reproductive traits in chicken using DNA sequencing. A total of 279 Dongxiang blue-shelled (DX) chickens and 232 Luhua (LH) chickens were used for validation. We detected 15 single nucleotide polymorphisms (SNPs): nine SNPs were previously unreported in chicken, two were missense mutations, and only three exhibited significant associations with reproductive traits. G.17156387C>T was significantly associated with age at first egg (AFE) and weight of first egg (WFE) in both breeds. Birds carrying the CC genotype exhibited higher AFE and WFE values than those with the TT genotype. The SNP g.17156427A>G exhibited an association with egg weight at 300 days of age (EWTA) in DX but not in LH chickens. The SNP g.17156703A>C affected the AFE and EN (total number of eggs at 300 days of age) in DX chickens. In addition, certain diplotypes significantly affected AFE, BWTA (body weight at 300 days of age), and EN in both breeds. RT-PCR results showed that the GDF9 gene was highly expressed in stroma with cortical follicles (STR) and prehierarchal follicles. These results provided further evidence that the GDF9 gene is involved in determining reproductive traits in chicken.

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Section: Methodsmentioning

confidence: 99%

Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits

Liu

Cui

Xiao

et al. 2018

BioMed Research International

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“…These diseases are caused by long-term energy metabolism disequilibrium, together with an imbalance between energy intake and energy expenditure. Studies have revealed that NPY is a major regulator in balancing energy metabolism [26, 94, 95] and resists excessive loss of fat by lipolysis in calorie-restricted mice indicating a trait potential for the life-extending effect of calorie restriction [95]. The NPY receptors, as is reported, can regulate energy balance and body weight in a cooperative manner.…”

Section: The Characteristics Of Human Npy Receptorsmentioning

confidence: 93%

A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans

et al. 2017

Cell Physiol Biochem

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Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982. While it is the most recently discovered member of the pancreatic polypeptide family (which includes neuropeptide Y, gut-derived hormone peptide YY, and pancreatic polypeptide), NPY is the most abundant peptide found in the mammalian brain. In order to exert particular functions, NPY needs to bind to the NPY receptor to activate specific signaling pathways. NPY receptors belong to the class A or rhodopsin-like G-protein coupled receptor (GPCR) family and signal via cell-surface receptors. By binding to GPCRs, NPY plays a crucial role in various biological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Abnormal regulation of NPY is involved in the development of a wide range of diseases, including obesity, hypertension, atherosclerosis, epilepsy, metabolic disorders, and many cancers. Thus far, five receptors have been cloned from mammals (Y1, Y2, Y4, Y5, and y6), but only four of these (hY1, hY2, hY4, and hY5) are functional in humans. In this review, we summarize the structural characteristics of human NPY receptors and their role in metabolic diseases.

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“…The secretory peptide, Neuropeptide-Y (NPY), functions as an extracellular signal regulating adipogenesis by interacting with NPY receptors (Yang et al, 2008;Baker et al, 2009;Shipp et al, 2016). The expression of NPY promotes lipid deposition by promoting adipogenesis (Kuo et al, 2007;Baker et al, 2009;Zhang et al, 2015;Shipp et al, 2016) and inhibiting lipolysis (Valet et al, 1990;Park et al, 2014;Zhang et al, 2014;Liu et al, 2017). At the transcriptional level, NPY was the gene in turkey pmSCs most downregulated by cold stress during differentiation (Reed et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature and Selection for Growth on Intracellular Lipid Accumulation and Adipogenic Gene Expression in Turkey Pectoralis Major Muscle Satellite Cells

Strasburg

Reed

et al. 2021

Front. Physiol.

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As multipotential stem cells, satellite cells (SCs) have the potential to express adipogenic genes resulting in lipid synthesis with thermal stress. The present study determined the effect of temperature on intracellular lipid synthesis and adipogenic gene expression in SCs isolated from the pectoralis major (p. major) muscle of 7-day-old fast-growing modern commercial (NC) turkeys compared to SCs from unselected slower-growing turkeys [Randombred Control Line 2 (RBC2)]. Since proliferating and differentiating SCs have different responses to thermal stress, three incubation strategies were used: (1) SCs proliferated at the control temperature of 38°C and differentiated at 43° or 33°C; (2) SCs proliferated at 43° or 33°C and differentiated at 38°C; or (3) SCs both proliferated and differentiated at 43°, 38°, or 33°C. During proliferation, lipid accumulation increased at 43°C and decreased at 33°C with the NC line showing greater variation than the RBC2 line. During proliferation at 43°C, peroxisome proliferator-activated receptor-γ (PPARγ) and neuropeptide-Y (NPY) expression was reduced to a greater extent in the NC line than the RBC2 line. At 33°C, expression of PPARγ, NPY, and CCAAT/enhancer-binding protein-β (C/EBPβ) was upregulated, but only in the RBC2 line. During differentiation, both lines showed greater changes in lipid accumulation and in C/EBPβ and NPY expression if the thermal challenge was initiated during proliferation. These data suggest that adipogenic gene expression is more responsive to thermal challenge in proliferating SCs than in differentiating SCs, and that growth-selection has increased temperature sensitivity of SCs, which may significantly affect breast muscle structure and composition.

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Peripheral neuropeptide Y differentially influences adipogenesis and lipolysis in chicks from lines selected for low or high body weight

Cited by 14 publications

References 46 publications

Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits

Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits

A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans

Effect of Temperature and Selection for Growth on Intracellular Lipid Accumulation and Adipogenic Gene Expression in Turkey Pectoralis Major Muscle Satellite Cells

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