Peripheral neuropathy: pattern recognition for the pragmatist

Overell, James

doi:10.1136/jnnp.2011.241612

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…Studies (Warren, 2010;Das Nair, et al, 2016;Guimaraes, & sa, 2012) have showed that lower scores in visual-spatial perception of SPMS patients represent the effect of right hemisphere damage on visual spatial ability. This finding is in coordination with the findings of other studies (Rourke, & Convay, 1997;Spring, & Deutsch, 1998;Harnadek, & Rourke, 1994;Furest, 1990;Amato, et al, 2010;Overell, 2011;Bergendal, 2014;Langdon, 2011).…”

Section: Discussionsupporting

confidence: 92%

“…Different levels of paramnesia in MS patients are related to some issues like the length of illness and its severity, having mood disorders, and types of MS (Das Nair, Martin, & Lincoln, 2012). The results of some studies were representative of the weakness of semantic memory in these patients (Goldstein, McKendall, & Haut, 1992;Overell, 2011). However, investigations showed that MS patients having severe depression suffered from significant injuries in working memory, procedural memory, and declarative memory (Grigsby, & Foonge, 1993;Chelune, Feisthamel, & Stone, 2004;Sawcer, Franklin, & Ban, 2014).…”

Section: Introductionmentioning

confidence: 96%

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Evaluation of Cognitive Abilities of Different Groups of Sclerosis Patients and Its Comparison With Healthy People

Pirkhaefi

2018

PCP

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Sclerosis is a neurodegenerative disease that is important in measuring and evaluating the cognitive abilities of its patients. Therefore, the diagnostic dimensions of functional differences in cognitive abilities of subgroups of this disease are important. Methods: The research was done with post-event design. The sample consisted of 60 subjects from different groups of patients with sclerosis in Tehran. The research tool was a cognitive test of Montreal. The research hypotheses were analyzed by MANOVA test. Results: The findings showed that there are some differences between the different subgroups of sclerosis patients and healthy people. There was no difference in memory function between the subgroups of sclerosis. Healthy individuals differed in working memory (4.43 vs. 1.83 to 2.23), cognitive function (27.7 vs. 19 to 21.9), attention and centralization (5.3 vs. 3.9 to 4.8), and visual spatial perception (4.6 vs. 2 to 2.9) with patients. Conclusion: The findings indicate that there are some differences in the cognitive functions of different groups of sclerosis. The results emphasize the role of cognitive rehabilitation for patients.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 96%

Evaluation of Cognitive Abilities of Different Groups of Sclerosis Patients and Its Comparison With Healthy People

Pirkhaefi

2018

PCP

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“…They most commonly result from chronic mechanical injuries of nerve tracts in fibro-osseous canals or compression by other tissue structures, including tendons, ligaments, and muscles [ 1 , 2 ]. Slow development of peripheral neuropathies is also a frequent manifestation of diabetes mellitus (DM) or toxic agent exposure [ 3 – 6 ]. On the other hand, peripheral neuropathies are an early clinical feature of systemic sclerosis (SSc) [ 7 ] and various related systemic disorders characterized by prominent tissue fibrosis, vascular alterations and immune-inflammatory changes including the toxic oil syndrome (TOS), eosinophilia-myalgia syndrome (EMS), nephrogenic systemic fibrosis (NSF), and eosinophilic fasciitis (EF) [ 8 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Progressive multifocal fibrosing neuropathy: description of a novel disease

Mendoza

Bagley

Gochfeld

et al. 2022

acta neuropathol commun

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Entrapment peripheral neuropathies are clinically characterized by sensory impairment and motor deficits. They are usually caused by mechanical injuries, but they are also a frequent manifestation of metabolic diseases, toxic agent exposure, or systemic fibrotic disorders. Here we describe the clinical, radiological, and histopathological features of a novel progressive fibrotic disorder characterized by progressive multifocal fibrosing neuropathy. We identified two patients who presented with severe and progressive peripheral neuropathic symptoms sequentially affecting multiple sites. These patients presented with severe and progressive multifocal, sequentially additive peripheral neuropathic symptoms. Extensive nerve conduction and radiological studies showed the sequential development of multifocal motor and sensory peripheral neuropathy in the absence of any exposure to known infectious, inflammatory, or fibrotic triggers and the lack of family history of compression neuropathies. Extensive clinical and laboratory test evaluation failed to support the diagnosis of any primary inflammatory or genetic peripheral neuropathy and there was no evidence of any systemic fibrosing disorder including Systemic Sclerosis, lacking cutaneous fibrotic changes and cardiopulmonary abnormalities. The clinical course was progressive with sequential development of motor and sensory deficits of upper and lower extremities displaying proximal predominance. Histopathological study of tissues obtained during nerve release surgeries showed severe perineural fibrosis with marked accumulation of thick collagen bundles encroaching the peripheral nerves. There was no evidence of vasculitic, inflammatory, or vascular fibroproliferative lesions. We suggest that the clinical findings described here represent a previously undescribed fibrotic disorder affecting peripheral nerves, and we propose the descriptive term "Progressive Multifocal Fibrosing Neuropathy" to refer to this novel disorder. Despite the inherent limitations of this early description, we hope this is would contribute to the identification of additional cases.

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“…Although the learners may have encountered similar approaches during the learning of the normal neurological examination ( 4 – 7 ), the rationale for learning the current method is that a systematic approach will help organize the appropriate clinical features helpful in differentiating localizations. The significance of learning this method well is that it can be applied to multiple scenarios and can form a base on which to add additional layers of neuromuscular localization, including differentiating between plexus lesions and the mononeuropathies and radiculopathies covered here.…”

Section: Introductionmentioning

confidence: 99%

Distinguishing Radiculopathies from Mononeuropathies

Robblee

Katzberg

2016

Front. Neurol.

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Identifying “where is the lesion” is particularly important in the approach to the patient with focal dysfunction where a peripheral localization is suspected. This article outlines a methodical approach to the neuromuscular patient in distinguishing focal neuropathies versus radiculopathies, both of which are common presentations to the neurology clinic. This approach begins with evaluation of the sensory examination to determine whether there are irritative or negative sensory signs in a peripheral nerve or dermatomal distribution. This is followed by evaluation of deep tendon reflexes to evaluate if differential hyporeflexia can assist in the two localizations. Finally, identification of weak muscle groups unique to a nerve or myotomal pattern in the proximal and distal extremities can most reliably assist in a precise localization. The article concludes with an application of the described method to the common scenario of distinguishing radial neuropathy versus C7 radiculopathy in the setting of a wrist drop and provides additional examples for self-evaluation and reference.

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Peripheral neuropathy: pattern recognition for the pragmatist

Cited by 9 publications

References 17 publications

Evaluation of Cognitive Abilities of Different Groups of Sclerosis Patients and Its Comparison With Healthy People

Evaluation of Cognitive Abilities of Different Groups of Sclerosis Patients and Its Comparison With Healthy People

Progressive multifocal fibrosing neuropathy: description of a novel disease

Distinguishing Radiculopathies from Mononeuropathies

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