Peripheral neuropathy in sarcoidosis

Tavee, Jinny

doi:10.1016/j.jneuroim.2022.577864

Cited by 13 publications

(15 citation statements)

References 68 publications

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“…In a recent narrative review from Tavee ( 122 ), peripheral nerve involvement in sarcoidosis (SA) is distinguished in granulomatous neuropathy (GN) and the more recently described non-granulomatous small fibers neuropathy (NGSFN). The two clinical entities differ for anatomo-pathologic features and clinical presentation.…”

Section: Neuropathies In the Most Common Acquired Rheumatological Con...mentioning

confidence: 99%

High-resolution ultrasound of peripheral neuropathies in rheumatological patients: An overview of clinical applications and imaging findings

Picasso¹,

Pistoia

Sanguinetti

et al. 2022

Front. Med.

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Peripheral neuropathies are surprisingly common and can be associated with a number of conditions, including rheumatological diseases. Whether the co-existence of peripheral neuropathies with rheumatological disorders is coincidental or related to a common pathogenic mechanism, these disabling conditions can affect the outcome of rheumatological patients and should be targeted with specific treatment. The clinical presentation of peripheral neuropathy can be multifaceted and difficult to recognize in polysymptomatic patients. However, physicians adopting state-of-art diagnostic strategies, including nerve imaging, may improve the detection rate and management of neuropathies. In particular, a diagnostic approach relying exclusively on clinical history and nerve conduction studies may not be sufficient to disclose the etiology of the nerve damage and its anatomical location and thus requires integration with morphological studies. High-Resolution Ultrasound (HRUS) is increasingly adopted to support the diagnosis and follow-up of both joint disorders in rheumatology and peripheral neuropathies of different etiologies. In this review, the different types of nerve disorders associated with the most common syndromes of rheumatological interest are discussed, focusing on the distinctive sonographic features.

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Section: Neuropathies In the Most Common Acquired Rheumatological Con...mentioning

confidence: 99%

High-resolution ultrasound of peripheral neuropathies in rheumatological patients: An overview of clinical applications and imaging findings

Picasso¹,

Pistoia

Sanguinetti

et al. 2022

Front. Med.

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“…Immune-mediated SFN can develop in different circumstances. It can be a manifestation of an underlying systemic disease, like sarcoidosis [11 ▪ ,12 ▪ ] or Sjögren syndrome [13 ▪ ,14 ▪ ]. In addition, various auto-antibodies have been linked to SFN, in the absence of systemic diseases [15 ▪ ,16 ▪▪ ,17 ▪▪ ].…”

Section: Immune-mediated Small Fiber Neuropathymentioning

confidence: 99%

“…When immune-mediated SFN is suspected, immunotherapy seems to be the treatment of first choice. Several case reports about SFN with an underlying systemic disease showed variable positive results of treatment with intravenous immunoglobulins (IVIG), plasma exchange, high dosed steroids or biologicals [10 ▪▪ ,11 ▪ ,13 ▪ ]. However, randomized controlled trials in these patient groups are lacking.…”

Section: Immune-mediated Small Fiber Neuropathymentioning

confidence: 99%

“…Sarcoidosis is one of the systemic diseases, in which the association with SFN has been quite clear for many years [11 ▪ ]. In contrast to the rare granulomatous neuropathies, with granulomatous inflammation and signs of perineuritis in nerve biopsies, SFN in much more common in sarcoidosis and considered to be the result of a systemic immune-mediated inflammation.…”

Section: Immune-mediated Small Fiber Neuropathymentioning

confidence: 99%

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Small fiber neuropathies: expanding their etiologies

Hoeijmakers

Merkies

Faber

2022

Current Opinion in Neurology

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Purpose of reviewSeveral conditions have been associated with the development of small fiber neuropathy (SFN). The list of metabolic, immune-mediated, infectious, toxic, drugs-related, and hereditary conditions is still growing and various hypotheses are made about the underlying pathophysiological mechanisms. Understanding these processes is important to provide new targets for treatment. In addition, the specific SFN phenotype can provide direction for the underlying etiology. This review discusses the latest developments concerning the expanding etiologies in SFN. Recent findingsIn the past 18 months, special attention has been paid to immunological etiologies, partly due to the coronavirus disease 2019 pandemic, but also new auto-antibodies in SFN have been demonstrated. Identifying patients with immune-mediated SFN can be challenging, since contrary to the classical distal sensory phenotype, a nonlength-dependent pattern is more common. Besides the etiologies of classical SFN, small fiber pathology is increasingly described in diseases without the typical neuropathic pain features of SFN, sometimes called syndromic SFN. However, the clinical relevance is not yet fully understood.

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“…Clinical presentation of neurosarcoidosis very variable. Neurologic manifestations can occur in approximately 10% of all patients with sarcoidosis, and peripheral neuropathy is presented in 5-10% of patients ( 3 - 6 ).…”

Section: Introductionmentioning

confidence: 99%

Neurosarcoidosis - the Role of Magnetic Resonance Imaging in Diagnostics

Imširović¹,

Guso²,

Omerhodžić³

et al. 2023

Acta Inform Med

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Background: Sarcoidosis is a multisystem granulomatous disease of unknown etiology, characterized by presence of granulomas in affected tissues with variety in clinical presentations and presents a differential diagnostic and therapeutic dilemma. Clinical presentation of neurosarcoidosis is very variable. Diagnosis is based on clinical and radiological criteria and histological findings of disseminated non-necrotic granuloma followed by negative cultures for bacteria and fungi. MRI plays a key role in detection of lesions located in the brain parenchyma. Objective: The aim of this article was to present case of a 36-year-old male patient, who came to doctor with symptoms of fever, dry cough with whitish sputum, lymphadenopathy of neck region and neurological disturbances in form of headaches and vision problems. Case presentation: Patient underwent on pulmonary examination and results indicated presence of sarcoidosis. CT examination was performed (SIEMENS Somatom Definition AS, Erlangen, Germany), which confirmed presence of mediastinal and hilar lymphadenopathy. Ultrasound (US) examination of a neck region was also performed showed significantly enlarged and morphology altered lymph nodes. After biopsy of several neck lymph nodes, histopathological was proven diagnosis of sarcoidosis. Due to neurological disturbances in form of headaches and vision problems patient was examined by an ophthalmologist, neurologist and endocrinologist. Hormonal analysis showed an increase of prolactin and that raised suspicion for neurosarcoidosis. In further diagnostic evaluation it was indicated MRI examination of the brain with focus on sellar region. Conclusion: Contrast-enhanced MRI is the modality of choice for investigating suspected neurosarcoidosis. The versatility of MR recording and the amount of diagnostic informations obtained from MRI examination is huge. Comparison of MRI sequences obtained, facilitate interpretation of these findings. Obtained MRI information and available literature, correlating with other diagnostic modalities (ultrasound and CT) facilitate understanding of the specific pathology.

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Peripheral neuropathy in sarcoidosis

Cited by 13 publications

References 68 publications

High-resolution ultrasound of peripheral neuropathies in rheumatological patients: An overview of clinical applications and imaging findings

High-resolution ultrasound of peripheral neuropathies in rheumatological patients: An overview of clinical applications and imaging findings

Small fiber neuropathies: expanding their etiologies

Neurosarcoidosis - the Role of Magnetic Resonance Imaging in Diagnostics

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