Peripheral neuropathy in a cat with renal lymphoma

Cavana, Paola; Sammartano, Federica; Capucchio, M.T.; Catalano, D; Valazza, Alberto; Farca, Anna Maria

doi:10.1016/j.jfms.2009.03.010

Cited by 18 publications

(20 citation statements)

References 13 publications

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“…[1][2][3] Acquired forms are attributed to infectious agents, intoxications, metabolic, immune-mediated, inflammatory, neoplastic, or paraneoplastic conditions, although a definitive cause is not identified in most cases. 1,[3][4][5][6][7][8][9][10][11][12][13] There is a genetic predisposition to disease affecting young cats of several breeds including Snowshoe, Abyssinian, and Bengal cats. 2,[14][15][16][17] Clinical presentations among the published cases are variable, but consistent findings include progressive neuromuscular weakness in young animals with potential for relapse of signs and no consistent response to, or recommendation for, specific therapy.…”

Section: Introductionmentioning

confidence: 99%

Juvenile‐onset motor polyneuropathy in Siberian cats

Crawford

Dreger

Shelton

et al. 2020

Veterinary Internal Medicne

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Background Polyneuropathies are infrequently described in cats. There is a genetic predisposition in several breeds. Objective To clinically characterize a novel motor polyneuropathy in a family of Siberian cats. Animals Thirteen closely related Siberian cats, 4 clinically affected and 9 clinically unaffected individuals. Methods Retrospective study. Clinical data and pedigree information were obtained from the medical records and breeder. Electrodiagnostic testing and muscle and peripheral nerve biopsy samples were obtained from 1 affected cat. Follow‐up information was obtained for all affected cats. Results Onset of signs was 4 to 10 months in affected cats. Clinical signs were progressive or waxing/waning neuromuscular weakness (4/4), normal sensory function (4/4), and variably decreased withdrawal reflexes (3/4). All cats returned to normal neurologic function within 1 to 4 weeks. All cats had a recurrence of weakness (3/4 had 1 recurrent episode, 1/4 had 3 relapses) from which they recovered fully. In 1 cat, electromyography and motor nerve conduction studies showed multicentric spontaneous activity, normal motor nerve conduction velocity, reduced compound muscle action potential amplitude, and polyphasia. Histologic evaluation of muscle and nerve in that cat showed mild muscle atrophy consistent with recent denervation, endoneurial and perineurial edema, and mild mononuclear cell infiltration within intramuscular nerve branches and a peripheral nerve. Pedigree analysis suggests an autosomal recessive mode of inheritance, although neither a genetically complex/polygenic condition nor an acquired inflammatory polyneuropathy can be ruled‐out. Conclusions and Clinical Importance We describe a motor polyneuropathy in juvenile Siberian cats characterized by self‐limiting weakness with potential relapse.

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Section: Introductionmentioning

confidence: 99%

Juvenile‐onset motor polyneuropathy in Siberian cats

Crawford

Dreger

Shelton

et al. 2020

Veterinary Internal Medicne

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“…Primary CNS lymphoma is a rare neoplasm in domestic felines, which often presents as a solitary, well-defined, and isolated intraparenchymal mass, or as a focally extensive infiltrate in the brain and/or spinal cord, which can be detected by CT, magnetic resonance imaging, or at necropsy examination (Troxel et al, 2003;Mandara et al, 2016;Yoshino et al, 2017). Neurologic paraneoplastic syndromes are reported in felines with lymphomas, including peripheral paraneoplastic neuropathy, axonal loss, and demyelination (Cavana et al, 2009;Guil-Luna et al, 2013). As previously described (Pedroso et al, 2018), paraneoplastic CCD is a type of paraneoplastic neurological syndrome associated with Hodgkin lymphoma, and rarely with non-Hodgkin lymphoma in humans.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat

Pardo¹,

Gómez²,

González³

2019

Open Vet J.

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Background: Cerebellar cortical degeneration (CCD) is the premature death of cerebellar neurons of heterogeneous etiology that is uncommonly observed as a neurological complication of certain neoplasia. Case Description: Here, we report an 8-month-old male domestic cat with altered consciousness, symmetric ataxia, hypermetric gait, vertical positional nystagmus, mydriasis, strabismus, intention tremor of the head, and increased patellar reflexes. Neuroanatomical diagnosis suggested a multifocal brain dysfunction (cerebellar and cerebral). The cat tested seropositive for feline leukemia virus. Cerebrospinal fluid analysis indicated mononuclear and neutrophilic pleocytosis. Contrast computed tomography imaging revealed multiple hypodense heterogeneous areas in both cerebral hemispheres, mild ventriculomegaly at the level of the caudal fossa, and a circular sharply marginated, homogeneously hyperdense mass occupying the right cerebellar hemisphere. Postmortem study indicated a 1.1 × 1.3 × 1.2 cm mass in the right cerebellar hemisphere close to the vermis. Histopathological analysis showed diffuse and severe Purkinje cell loss with a decrease in granular cell density and moderate gliosis compatible with CCD. Further, numerous neoplastic lymphoid cells were observed in the infiltrated mass, consistent with a diagnosis of central nervous system (CNS) lymphoma. Immunohistochemistry showed CD20 expression, indicative of a B-cell immunophenotype. In humans, CCD is reported as a rare paraneoplastic syndrome in patients with Hodgkin lymphoma. CNS lymphoma and/or Feline Leukemia Virus (FeLV) infection were both considered as a possible cause of CCD in this case. Conclusion: This is the first described case of possible paraneoplastic cerebellar cortical degeneration associated with CNS lymphoma and/or FeLV infection in a domestic cat.

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“…In companion animals, paraneoplastic neuropathies have been reported sporadically in malignant tumors, and include bronchogenic carcinoma, insulinoma, leiomyosarcoma, hemangiosarcoma, undifferentiated sarcoma, synovial sarcoma and adrenal adenocarcinoma [114,[127][128][129]. Viviers and Dobson [22] described the case of a 12-year-old female German Shepherd dog that developed progressive hindlimb followed by forelimb ataxia with tetraplejia.…”

Section: Other Clinical Signsmentioning

confidence: 99%

Multiple Myeloma in Horses, Dogs and Cats: A Comparative Review Focused on Clinical Signs and Pathogenesis

Muñoz¹,

Riber²,

Satué³

et al. 2013

Multiple Myeloma - A Quick Reflection on the Fast Progress

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Additional information is available at the end of the chapter http://dx.doi.org/10.5772/54311 . IntroductionMultiplκ myκloma MM or plasma cκll myκloma is a nκoplastic proliλκration oλ plasma cκlls that primarily involvκs thκ bonκ marrow but may originatκ λrom κxtramκdullary sitκs [ -]. Although it is uncommon in vκtκrinary mκdicinκ, it has bκκn rκportκd in sκvκral spκciκs, including cats, dogs and, horsκs [ , , -]. Thκ λrκquκncy oλ MM in cats is slightly < % oλ all malignant nκoplasms. Caninκ MMs account λor only . % oλ all malignanciκs in dogs. MMs account approximatκly % oλ all hκmatopoiκtic nκoplasms in both dogs and cats [ ]. Most oλ thκ rκports in thκ litκraturκ arκ limitκd to to casκ studiκs [ , -]. Howκvκr, in a rκcκnt rκport rκgarding thκ incidκncκ oλ bonκ disordκrs diagnosκd in dogs, MM was thκ sκcond most λrκquκntly diagnosκd nκoplastic condition in caninκ bonκ marrow [ ].Similarly, MM is an κxtrκmκly rarκ disordκr in horsκs. Tκn casκs, ninκ λrom thκ litκraturκ and a nκw casκ, wκrκ dκscribκd by Edwards κt al. [ ] and only six additional casκs havκ bκκn dκscribκd lastly [ , -, ]. Bκcausκ oλ thκ uncommonly diagnosis oλ κquinκ MM, thκ prκvalκncκ oλ this nκoplasm is unknown in thκ horsκ. . Data of the patients with multiple myelomaMM is gκnκrally a disκasκ oλ oldκr animals, although somκ rκports κxist in young animals. In dogs, thκ avκragκ agκ oλ diagnosis is bκtwκκn and yκar-old [ -, , -].Thκrκ is a rκport oλ MM in a youngκr dog, -yκar-old [ ]. Thκrκ is no apparκnt gκndκr prκdisposition

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Peripheral neuropathy in a cat with renal lymphoma

Cited by 18 publications

References 13 publications

Juvenile‐onset motor polyneuropathy in Siberian cats

Juvenile‐onset motor polyneuropathy in Siberian cats

Cerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat

Multiple Myeloma in Horses, Dogs and Cats: A Comparative Review Focused on Clinical Signs and Pathogenesis

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