Peripheral Neuropathy due to Disulfiram

Bradley, William G.; Hewer, Raymond

doi:10.1136/bmj.2.5511.449

Cited by 26 publications

(7 citation statements)

References 8 publications

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“…Neurotoxic effects have been established for a number of dithiocarbamates including ferbam, ziram (zinc dimethyldithiocarbamate) and thiram in rats (15), thiram in chickens (22), antabuse (tetraethylthiuram disulfide) in rats (23) and in man (24)(25)(26), ethyl namate (sodium diethyldithiocarbamate) in hens (27) and in rabbits (28), and tecoram (an oxidation product of disodium ethylenebisdithiocarbamate and ethyl namate with ammonium persulfate) in chick embryos (29). Two carbamate pesticides, carbaryl (1-naphthyl-N-methylcarbamate) and aprocarb (2-isopropoxyphenyl-Nmethylcarbamate), were also reported to be neurotoxic in rats and swine (30)(31)(32).…”

Section: Open-field Testmentioning

confidence: 99%

Neurotoxicity and behavioral effects of thiram in rats.

Lee¹,

Peters²

1976

Environ Health Perspect

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Eight of 24 female rats fed 66.9 mg/kg-day of thiram developed neurotoxicity. The neurotoxic effects were characterized by ataxia and paralysis of the hind legs. There were demyelination, degeneration of the axis cylinders, and presence of macrophages in the nerve bundle of the sciatic nerve. Degeneration in the ventral horn of the lower lumbar region of the spinal cord was evidenced by chromatolysis of motorneurons, pyknosis, and satellitosis. During a second experiment, 4 of 24 females fed 65.8 mg/kgday also developed ataxia and paralysis. An additional 9 females showed clasping of the hind feet when picked up by the tail. Nerve conduction could not be measured for one severely ataxic rat and the electromyogram indicated a loss of motor unit function. Histopathology of this rat, along with the others, suggests the peripheral nerve as the primary site of the lesion. Thiram also caused behavioral changes in apparently normal rats. The walking pattern of the hind legs was altered with decreases in stride width and the angle between contralateral steps. These rats required significantly more shockmotivations and cleared a lower height in a jump/climb ability test. An open-field study indicated that thiram caused hyperactivity in the nonataxic rats of both sexes. Three of 24 rats fed 95.8 mg/kg-day of ferbam also developed ataxia or paralysis.

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Section: Open-field Testmentioning

confidence: 99%

Neurotoxicity and behavioral effects of thiram in rats.

Lee¹,

Peters²

1976

Environ Health Perspect

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“…Although it is well tolerated in most patients, one in 15,000 patients will develop neuropathy every year [1]. Disulfiram neuropathy presents with various clinical presentations: polyneuritis with sensory, motor or both deficits [2,3], quadriplegia [4] and optic neuritis [5,6]. Disulfiram neuropathy can be mild or severe, depending on duration of exposure and the dosage.…”

Section: Introductionmentioning

confidence: 99%

Disulfiram-induced neuropathy: a case report

Mohapatra

Sahoo

Rath

2015

General Hospital Psychiatry

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“…Since 1953, only 11 cases of disulfiram-induced optic neuropathy have been described, and all cases had been reversible [10]. The mechanism of disulfiram-induced optic neuropathy has been attributed to a metabolite of this drug, known as carbon disulphide.…”

Section: Discussionmentioning

confidence: 99%