Peripheral neuropathy associated with fluoroquinolones

Aoun, Michel; Jacquy, Caroline; Debusscher, L; Bron, Denis; Lehert, M.; Noe͏̈l, Patrick; Auwera, P. Van der

doi:10.1016/0140-6736(92)90460-k

Cited by 21 publications

(15 citation statements)

References 2 publications

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“…In addition, the U.S. Food and Drug Administration (FDA) issued black box warnings for fluoroquinolones in 2016 [13] and 2018 [14,15] that fluoroquinolones should not be used for uncomplicated UTIs in patients who have other treatment options. These FDA warnings are based on studies indicating an association between fluoroquinolone use and tendonitis and tendon rupture [16,17], QT-prolongation [18], dysglycemia [19,20], neuropathy [21,22,23], and potentially aortic rupture [15].…”

Section: Introductionmentioning

confidence: 99%

Qualitative Analysis of Primary Care Provider Prescribing Decisions for Urinary Tract Infections

et al. 2019

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Inappropriate choices and durations of therapy for urinary tract infections (UTI) are a common and widespread problem. In this qualitative study, we sought to understand why primary care providers (PCPs) choose certain antibiotics or durations of treatment and the sources of information they rely upon to guide antibiotic-prescribing decisions. We conducted semi-structured interviews with 18 PCPs in two family medicine clinics focused on antibiotic-prescribing decisions for UTIs. Our interview guide focused on awareness and familiarity with guidelines (knowledge), acceptance and outcome expectancy (attitudes), and external barriers. We followed a six-phase approach to thematic analysis, finding that many PCPs believe that fluoroquinolones achieve more a rapid and effective control of UTI symptoms than trimethoprim-sulfamethoxazole or nitrofurantoin. Most providers were unfamiliar with fosfomycin as a possible first-line agent for the treatment of acute cystitis. PCPs may be misled by advanced patient age, diabetes, and recurrent UTIs to make inappropriate choices for the treatment of acute cystitis. For support in clinical decision making, few providers relied on guidelines, preferring instead to have decision support embedded in the electronic medical record. Knowing the PCPs’ knowledge gaps and preferred sources of information will guide the development of a primary care-specific antibiotic stewardship intervention for acute cystitis.

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Section: Introductionmentioning

confidence: 99%

Qualitative Analysis of Primary Care Provider Prescribing Decisions for Urinary Tract Infections

et al. 2019

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“…One case of peripheral neuropathy has been reported 3. We report two cases of generalised painful dysaesthesia due to ciprofloxacin, a reaction not previously associated with this particular fluoroquinolone.…”

mentioning

confidence: 77%

Drug points: Painful dysaesthesia with ciprofloxacin

Zehnder

Hoigné²,

Neftel³

et al. 1995

BMJ

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“…In the case that we are presenting, we treated the patient with IVIG after other treatments failed. 2 , 9 , 10 …”

Section: Discussionmentioning

confidence: 99%

Quinolone-Induced Painful Peripheral Neuropathy: A Case Report and Literature Review

Estofan

Naydin

Gliebus

2018

Journal of Investigative Medicine High Impact Case Reports

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We present a case report of a 20-year-old male with diabetes mellitus type 1, who developed severe painful peripheral neuropathy while on the second of a 10-day course with levofloxacin for the treatment of epididymitis. The intensity of the pain rapidly reached scores of 10/10 in a numeric scale 0/10, and the patient was transferred to an inpatient pain unit where he was treated aggressively with minimal improvement. A skin biopsy revealed small fiber neuropathy. Then the patient was treated with intravenous immunoglobulin, which improved the pain. Now the patient is on outpatient intravenous immunoglobulin infusions bimonthly and making a slow recovery.

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Peripheral neuropathy associated with fluoroquinolones

Cited by 21 publications

References 2 publications

Qualitative Analysis of Primary Care Provider Prescribing Decisions for Urinary Tract Infections

Qualitative Analysis of Primary Care Provider Prescribing Decisions for Urinary Tract Infections

Drug points: Painful dysaesthesia with ciprofloxacin

Quinolone-Induced Painful Peripheral Neuropathy: A Case Report and Literature Review

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