Peripheral neuropathy and Guillain-Barré syndrome risks associated with exposure to systemic fluoroquinolones: a pharmacovigilance analysis

Ali, Ayad

doi:10.1016/j.annepidem.2013.12.009

Cited by 55 publications

(40 citation statements)

References 14 publications

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“…22 The mechanism of action 23 involves the inhibition of bacterial DNA topoisomerase II (gyrase) and topoisomerase IV, which are enzymes involved in untwining bacterial DNA during the replication process. Regrettably, CIP has also been shown to decrease the viability of eukaryotic cells, leading to multiple adverse effects 24,25 , such as tendinopathies 26 and peripheral neuropathy 27,28 , due to a decline in the synthesis of proteins encoded in mitochondrial deoxyribonucleic acid (mtDNA). Analysis of mtDNA from CIP-treated cells revealed the presence of site-specific, double-stranded DNA breaks 29 , which were attributed to inhibition of mitochondrial topoisomerase II activity, functionally and structurally similar to that found in bacteria.…”

Section: Discussionmentioning

confidence: 99%

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

Kamocki

Bottino

2015

Archives of Oral Biology

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Objective A combination of antibiotics, including but not limited to metronidazole (MET) and ciprofloxacin (CIP), has been indicated to eradicate bacteria in necrotic immature permanent teeth prior to regenerative procedures. It has been shown clinically that antibiotic pastes may lead to substantial stem cell death. The aim of this study was to synthesize scaffolds containing various concentrations of CIP to enhance cell viability while preserving antimicrobial properties. Design Polydioxanone (PDS)-based electrospun scaffolds were processed with decreasing CIP concentrations (25 – 1 wt.%) and morphologically evaluated using scanning electron microscopy (SEM). Cytotoxicity assays were performed to determine whether the amount of CIP released from the scaffolds would lead to human dental pulp stem cell (hDPSC) toxicity. Similarly, WST-1 assays were performed to evaluate the impact of CIP release on hDPSC proliferation. Pure PDS scaffolds and saturated double antibiotic solution MET/CIP (DAP) served as both positive and negative controls, respectively. Antibacterial efficacy against E. faecalis (Ef) was tested. Results A significant decrease in hDPSC’ viability at concentrations 5–25 wt.% was observed. However, concentrations below 5 wt.% did not impair cell viability. Data from the WST-1 assays indicated no detrimental impact on cell proliferation for scaffolds containing 2.5 wt.% CIP or less. Significant antimicrobial properties were seen for CIP-scaffolds at lower concentrations (i.e., 1 and 2.5 wt.%). Conclusion The obtained data demonstrated that a reduced concentration of CIP incorporated into PDS-based scaffolds maintains its antimicrobial properties while enhancing viability and proliferation of dental pulp stem cells.

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Section: Discussionmentioning

confidence: 99%

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

Kamocki

Bottino

2015

Archives of Oral Biology

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“…There was a temporal association of the urinary tract infection, ciprofloxacin use, and the development of symptoms in patient 2. Both fluoroquinolone use and infection are known to be associated with IMN, and their possible causal role in the condition of patient 2, although unlikely, cannot be excluded [15,16]. …”

Section: Discussionmentioning

confidence: 99%

Immune-Mediated Neuropathies following Autologous Stem Cell Transplantation for Multiple Myeloma: Case Series and Review of the Literature

Mohyuddin¹,

Uy²,

Honhar³

et al. 2017

Acta Haematol

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Neuropathy is a common finding in patients with multiple myeloma. Several different factors can cause neuropathy in these patients, such as the underlying disease itself, medications used for treatment, or immune-mediated processes. Immune-mediated neuropathies (IMN) consist of a heterogeneous spectrum of peripheral nerve disorders. Although IMN is associated with several hematological disorders, it remains a very rare complication of hematopoietic stem cell transplantation (HCT). We describe our experiences of 3 patients with multiple myeloma who experienced IMN following autologous HCT (auto-HCT). These 3 patients were felt to have IMN clearly attributable to auto-HCT because of a clear temporal association with auto-HCT and absence of any other obvious causative factor. The variety in their clinical presentations, diagnostic approach, and approaches to management are explained. The pathophysiology of how HCT may predispose to IMN remains poorly understood. Our report helps highlight several potential causes of this phenomenon, such as a paraneoplastic syndrome, immune reconstitution syndrome, or drug toxicity. We emphasize that a comprehensive approach is needed to address this rare entity, and that there should be a low threshold to initiate immune-specific therapy, such as plasmapheresis, if symptoms do not resolve spontaneously.

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“…Todos los datos del estudio fueron obtenidos de forma automática a través de extracción electrónica de las historias clí-nicas (29 20). No obstante, la diferencia en término de medias no fue clínicamente significativa (25±8,6 días en el grupo de soluciones balanceadas vs 24,8±8,9 en el grupo de SSN 0,9 %).…”

Section: Solución Salina En Pacientes Críticamen-te Enfermos: ¿Estamounclassified

Ronda clínica y epidemiológica: club de revistas

Mendoza-Mendoza

Restrepo-Álvarez

Caraballo

et al. 2018

iatreia

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RESUMENEn esta nueva edición de la Ronda Clínica y Epidemiológica, el lector podrá encontrar cuatro artículos que consideramos de especial interés para la práctica clínica actual. Abuzaid A. et al, realizan una revisión sistemática y meta-análisis que compara los desenlaces de la terapia con oxígeno vs. sin oxígeno en escenarios post-infarto agudo de miocardio. Freund Y., et al, presentan un ensayo clínico cluster de no inferioridad en el que buscan validar prospectivamente la seguridad de una estrategia basada en criterios clínicos para descartar embolismo pulmonar. Por otro lado, por medio de un diseño de cohorte retrospectiva con emparejamiento por índice de propensión, Pasternak, et al, se proponen investigar si el uso de fluoroquinolonas orales se asocia con un incremento en el riesgo de aneurisma o disección aórtica. Por último, el grupo de investigadores SMART evalúa, a través de un ensayo clínico pragmático en pacientes críticamente enfermos, el impacto de soluciones balanceadas en comparación al uso de solución salina normal en el riesgo de desarrollar eventos renales mayores.

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Peripheral neuropathy and Guillain-Barré syndrome risks associated with exposure to systemic fluoroquinolones: a pharmacovigilance analysis

Cited by 55 publications

References 14 publications

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

Immune-Mediated Neuropathies following Autologous Stem Cell Transplantation for Multiple Myeloma: Case Series and Review of the Literature

Ronda clínica y epidemiológica: club de revistas

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