Peripheral Nervous System Involvement in Diabetes and Role of Rehabilitation

Jens, William K.; Ahmed, Aiesha

doi:10.4172/2376-0281.1000233

Cited by 3 publications

(2 citation statements)

References 53 publications

(61 reference statements)

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“…As duration of DM increases further accumulation of mediators cause further P100 prolongation. 19 Main limitation of this study was the sample size.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of central neuropathy in type 2 diabetes mellitus: a case control study

Balakrishnan¹,

Ramadoss²,

Venkatesan³

2019

Int J Res Med Sci

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Background: Diabetes mellitus (DM) is a global pandemic affecting almost every organ in the body. Peripheral nervous system involvement in diabetes is well known but there are not many studies on central nervous system involvement. Visual evoked potential (VEP) is a sensitive, non-invasive test to detect central demyelination of optic nerve. The objective was to compare the visual evoked potentials in type-2 DM patients with that of healthy controls and to find out if any correlation is there with the duration and glycaemic control of the disease and to compare incidence of peripheral and central neuropathy in DM patients.Methods: Author included 50 DM patients and 50 age and sex matched controls. Patients with previous stroke, demyelination, diabetic retinopathy and other ophthalmological disorders were excluded. VEP was recorded using pattern reversal stimulation with EMG RMS MARK II machine and p100 latency was measured.Results: P100 latencies (ms) was significantly prolonged in diabetics with mean±SD of (111.24±5.28 ms) as compared to controls (101.30±1.66 ms) with p value <0.003. Also, there was significant correlation between duration of DM and P100 latency prolongation, but no significant correlation was present when compared with glycaemic control.Conclusions: Central neuropathy is very common in DM. It is related to duration of DM and not HbA1c unlike PNP which is related to both. Central neuropathy occurs even prior to development of retinopathy or PNP. Hence, VEP is a non-invasive and sensitive screening tool for early neurological involvement in DM.

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“…As duration of DM increases further accumulation of mediators cause further P100 prolongation. 19 Main limitation of this study was the sample size.…”

Section: Discussionmentioning

confidence: 95%

Evaluation of central neuropathy in type 2 diabetes mellitus: a case control study

Balakrishnan¹,

Ramadoss²,

Venkatesan³

2019

Int J Res Med Sci

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“…The accumulation of these mediators probably delays the conduction in the visual pathway, which can be the probable cause of the delay in the latencies found in diabetics as compared to the healthy controls. With the increase in the duration of diabetes, the accumulation of these mediators also increases, which can cause further delay in the latencies in diabetics with more duration of the disease [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Utility of Visual Evoked Potentials (VEPs) study in the evaluation of visual pathway dysfunction in diabetics without retinopathy: correlations with diabetic peripheral neuropathy and other clinical findings

2024

RJO

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Neuro-Psychiatric Alterations in Patients with Diabetic Foot Syndrome

Navarro‐Flores

Pérez‐Ros

Martínez-Arnau

et al. 2019

CNSNDDT

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Diabetic Foot Syndrome (DFS) is a common long-term complication of diabetes mellitus. DFS has recently been associated with adverse effects on brain function which could further impair the quality of life of these patients, as well as increase the social and economic burden, morbidity, and premature mortality of the disease. The current knowledge of neuropsychiatric alterations e.g. cognitive impairment, gait disorder, depression, and quality of life in patients with diabetic foot syndrome is summarized. The cognitive domains altered in DFS are executive function, memory, and psychomotor speed. Compared to diabetic patients without DFS, individuals with DFS present gait alterations caused by changes in several spatio-temporal parameters and lower-limb kinematics. The increased rates of anxiety and depression among patients with DFS were related to several factors, including female sex, a smoking habit, age under 50 years, and foot ulceration exceeding 7 months' duration. The role of infections and the use of preventive antimicrobial treatment need further studies regarding their effect on comorbid neuropsychiatric disorders. The care of these patients should include the prevention, detection and treatment of these neuropsychiatric disorders in order to improve their quality of life.

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Peripheral Nervous System Involvement in Diabetes and Role of Rehabilitation

Cited by 3 publications

References 53 publications

Evaluation of central neuropathy in type 2 diabetes mellitus: a case control study

Evaluation of central neuropathy in type 2 diabetes mellitus: a case control study

Utility of Visual Evoked Potentials (VEPs) study in the evaluation of visual pathway dysfunction in diabetics without retinopathy: correlations with diabetic peripheral neuropathy and other clinical findings

Neuro-Psychiatric Alterations in Patients with Diabetic Foot Syndrome

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