Peripheral nerve ultrasound in amyotrophic lateral sclerosis phenotypes

Schreiber, Stefanie; Abdulla, Susanne; Dębska–Vielhaber, Grażyna; Machts, Judith; Dannhardt-Stieger, Verena; Feistner, Helmut; Oldag, Andreas; Goertler, Michael; Petri, Susanne; Kollewe, Katja; Kropf, Siegfried; Schreiber, Frank; Heinze, Hans‐Jochen; Dengler, Reinhard; Nestor, Peter J.; Vielhaber, Stefan

doi:10.1002/mus.24431

Cited by 60 publications

(95 citation statements)

References 52 publications

(110 reference statements)

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“…The nerve cross‐sectional area (CSA) was calculated by continuous manual tracing of the nerve circumference, excluding the hyperechoic epineural rim. Peripheral nerve ultrasound is well established locally with very good to excellent intra‐ and interrater agreements …”

Section: Methodsmentioning

confidence: 99%

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Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis

et al. 2017

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Section: Methodsmentioning

confidence: 99%

“…to have possible, probable, or definite ALS according to the revised El Escorial criteria . Of those 55 cases, 29 (53%) and 13 (24%) of patients, respectively, were included in our previous cross‐sectional and longitudinal peripheral nerve sonography ALS studies . Four subjects (7%) met the criteria for comorbid FTD .…”

Section: Methodsmentioning

confidence: 99%

Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis

et al. 2017

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“…Intuitively, one may expect reduced CSA in axonal PN due to loss of myelinated fibres. However, this is seldom apparent with the exception of modest reduction of nerve calibre in amyotrophic lateral sclerosis (ALS) 60 65 66. In fact, US of axonal PN may detect nerve enlargement in approximately 20% of patients 15…”

Section: Us Findings In Pnmentioning

confidence: 99%

Ultrasound in the diagnosis of peripheral neuropathy: structure meets function in the neuromuscular clinic

Gallardo

Noto

Simon

2015

J Neurol Neurosurg Psychiatry

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“…Schreiber and colleagues reported thinning of ulnar nerves in different subtypes of ALS, primarily based on the involvement of the upper and lower motor neurons (4). Because evaluation of cervical roots might provide information in the proximal muscles innervated by C5, C6, and C7 nerve roots, sonographic evaluation of peripheral nerve (e.g., median and ulnar nerves) as well as cervical nerve roots would be useful (3).…”

Section: Introductionmentioning

confidence: 99%

Sonographic evaluation of cervical nerve roots in ALS and its clinical subtypes

et al. 2016

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: Morphological assessment of peripheral nerves in amyotrophic lateral sclerosis (ALS) has been available by sonography. Detection of possible axonal atrophy could be important in predicting progression. Research on correlation between sonographic findings and clinical presentation has been sparse. The aim of the study was to assess possible motor axon loss in patients with ALS by sonography and to correlate the imaging features with clinical subtypes. Patients with either definite or probable ALS and control subjects had sonographic evaluation of the cervical nerve roots (C5, C6, and C7). Each diameter and their sums were measured. The ALS patients were classified by their clinical onset and progression (arm-onset, leg-onset, bulbar, and flail-arm variant) and the sonographic features were compared. Overall, the cervical nerve roots were thinner in ALS than in the controls, but the diagnostic sensitivity was low. The patients with arm dysfunctions tended to show thinner nerve roots than those with normal or relatively preserved arm functions. The four ALS subtypes showed similar diameters of the nerve roots. There was no correlation between the disease duration and the diameters of the nerve roots. Sonography of the cervical nerve roots showed axonal atrophy in ALS and potentially reflects subtle arm dysfunctions.

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Peripheral nerve ultrasound in amyotrophic lateral sclerosis phenotypes

Cited by 60 publications

References 52 publications

Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis

Peripheral nerve atrophy together with higher cerebrospinal fluid progranulin indicate axonal damage in amyotrophic lateral sclerosis

Ultrasound in the diagnosis of peripheral neuropathy: structure meets function in the neuromuscular clinic

Sonographic evaluation of cervical nerve roots in ALS and its clinical subtypes

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