Peripheral nerve structure and function in experimental diabetes

Axonal dwindling in early experimental diabetes. II. A study of isolated nerve fibres

“…The difference between this result and that obtained in the present study and that of Sharma and Thomas (1974) is not apparent. It may be of interest to note that a quantitative study of spontaneous diabetes in Chinese hamsters reported an increased disparity of internodal length [7].…”

“…The absence of segmental demyelination and remyelination is in accordance with the findings of Sharma and Thomas (1974) in rats with a duration of diabetes of from 3 to 49 weeks [5].…”

Peripheral nerve structures of experimental diabetes rats and the effect of insulin treatment.

“…In spite of precise morphometrical analysis with the aid of electron microscope, Sharma and Thomas (1974) could not find any significant changes in alloxan and streptozotocin diabetes rats over a year of diabetes-duration as compared with age-matched control rats. They explained that the delayed nerve conduction velocities detected in the diabetes rats were attributable to metabolic abnormalities of nodal gap, Schwann cell or axoplasm .…”

The effects of Sorbinil on peripheral nerve conduction velocity, polyol concentrations and morphology in the streptozotocin-diabetic rat

“…A similar pattem of conduction velocity changes has been reported in spontaneously diabetic rats [17], suggesting that the present findings resulted from the effects of diabetes rather than their being caused by any direct neurotoxic effect of streptozotocin. Some reports have noted a large drop in tibial conduction velocity below levels found at the onset of diabetes [18]. Most, but not all [9], of these results can be explained on methodological grounds, particularly by lack of control over nerve temperature [10].…”