Peripheral Nerve Stimulation: A Review of Techniques and Clinical Efficacy

Kaye, Alan D.; Ridgell, Sasha; Alpaugh, E. Saunders; Mouhaffel, Aya; Kaye, Aaron J.; Cornett, Elyse M.; Chami, Azam A.; Shah, Riaz Ahmad; Dixon, Bruce M.; Viswanath, Omar; Urits, Ivan; Edinoff, Amber N.; Urman, Richard D.

doi:10.1007/s40122-021-00298-1

Cited by 47 publications

(39 citation statements)

References 48 publications

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“…As it involved a minimally invasive procedure to place the device, there is also a risk of device-related complications. The success rate is around 80%, with most complications arising from more complicated issues rather than cluneal nerve neuropathy [6].…”

Section: Discussionmentioning

confidence: 99%

Peripheral Nerve Stimulation for Treatment of Cluneal Neuropathy Case Study

Soteropoulos¹,

Pergolizzi²,

Nagarakanti³

et al. 2022

Cureus

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Chronic low back pain is a prevalent and sometimes debilitating condition. This case report describes a 69year-old female presenting with axial spine pain. The pain was inadequately controlled by opioids as she was treated unsuccessfully with hydrocodone and remained to have the pain between 7/10 and 10/10. Peripheral neural stimulation (PNS) was trialed and then used to control her pain. PNS is a device-based treatment option that appears effective in a subset of patients. It has been effectively used to treat many different chronic pain syndromes. The patient responded well to the treatment, with her pain intensity going down to between 2/10 and 5/10 on the same scale. She was able to discontinue her use of opioids. PNS can be a safe and effective treatment in patients who have not responded well to pharmacologic analgesia.

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Section: Discussionmentioning

confidence: 99%

Peripheral Nerve Stimulation for Treatment of Cluneal Neuropathy Case Study

Soteropoulos¹,

Pergolizzi²,

Nagarakanti³

et al. 2022

Cureus

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“…It is well understood that interneurons within the spinal cord contain GABAergic inhibitor signals which can modulate ascending pain signals. 39 The goal of minimally invasive treatment is stimulation of these GABAergic inhibitory interneurons to modulate and decrease ascending pain signals. There have been recent advances in nonsurgical modalities of pain management including neuromodulation with peripheral nerve stimulation, 40 pulsed radiofrequency, 41 and transcutaneous electrical nerve stimulation (TENS).…”

Section: Minimally Invasive Treatmentmentioning

confidence: 99%

“…43 These FDA-approved devices can solve previous problems of off-label peripheral nerve stimulators in terms of their long-term stability, complexity, and effectiveness. 39 These wireless systems have introduced the opportunity for management of chronic neuropathic pain through target nerve stimulation resulting in paresthesia in the given nerve distribution. 39 The results of our literature search regarding peripheral nerve stimulation are summarized in Table 2.…”

Section: Peripheral Nerve Stimulationmentioning

confidence: 99%

Outcomes after minimally invasive and surgical management of suprascapular nerve entrapment: A systematic review

et al. 2022

Self Cite

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Background The prevalence of suprascapular neuropathy is higher than previously estimated. Recent literature highlights a myriad of treatment options for patients ranging from conservative treatment and minimally invasive options to surgical management. However, there are no comprehensive review articles comparing these treatment modalities. Objective The purpose of this review article is to summarize the current state of knowledge on suprascapular nerve entrapment and to compare minimally invasive treatments to surgical treatments. Methods The literature search was performed in Mendeley. Search fields were varied redundant. All articles were screened by title and abstract and a preliminary decision to include an article was made. A full-text screening was performed on the selected articles. Any question regarding the inclusion of an article was discussed by 3 authors until an agreement was reached. Results Recent studies have further elucidated the pathoanatomy and described several risk factors for entrapment ranging. Four studies met our inclusion criteria regarding peripheral nerve stimulation with good pain and clinical outcomes. Two studies met our inclusion criteria regarding pulsed radiofrequency and showed promising pain and clinical outcomes. One study met our inclusion criteria regarding transcutaneous electrical nerve stimulation and showed good results that were equivalent to pulsed radiofrequency. Surgical treatment has shifted to become nearly all arthroscopic and surgical outcomes remain higher than minimally invasive treatments. Conclusions Many recently elucidated anatomical factors predispose to entrapment. A history of overhead sports or known rotator cuff disease can heighten a clinician’s suspicion. Entrapment at the suprascapular notch is more common overall, yet young athletes may be predisposed to isolated spinoglenoid notch entrapment. Pulsed radiofrequency, peripheral nerve stimulation, and transcutaneous electrical nerve stimulation may be effective in treating patients with suprascapular nerve entrapment. Arthroscopic treatment remains the gold-standard in patients with refractory entrapment symptoms.

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“…The mechanism of nerve regeneration is complex, the speed of nerve growth is relatively slow, and the target muscle loses innervation and then atrophies [ 5 , 6 ]. Persistent sensory and motor defects are common in the affected nerve control areas, which may develop neuropathic pain and cause lifelong disability due to limb paralysis [ 7 ]. This causes a decline in the quality of life and psychological obstacles to patients and brings a significant economic and social burden.…”

Section: Introductionmentioning

confidence: 99%

Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration

Zhang

Liu

et al. 2022

Gels

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Peripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. As the gold standard of treatment, autologous nerve grafting has several disadvantages, such as lack of donors and complications. The use of functional biomaterials to simulate the natural microenvironment of the nervous system and the combination of different biomaterials are considered to be encouraging alternative methods for effective tissue regeneration and functional restoration of injured nerves. Considering the inherent presence of an electric field in the nervous system, electrically conductive biomaterials have been used to promote nerve regeneration. Due to their singular physical properties, hydrogels can provide a three-dimensional hydrated network that can be integrated into diverse sizes and shapes and stimulate the natural functions of nerve tissue. Therefore, conductive hydrogels have become the most effective biological material to simulate human nervous tissue’s biological and electrical characteristics. The principal merits of conductive hydrogels include their physical properties and their electrical peculiarities sufficient to effectively transmit electrical signals to cells. This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration.

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Peripheral Nerve Stimulation: A Review of Techniques and Clinical Efficacy

Cited by 47 publications

References 48 publications

Peripheral Nerve Stimulation for Treatment of Cluneal Neuropathy Case Study

Peripheral Nerve Stimulation for Treatment of Cluneal Neuropathy Case Study

Outcomes after minimally invasive and surgical management of suprascapular nerve entrapment: A systematic review

Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration

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