Peripheral nerve sheath tumors arising in salivary glands: A clinicopathologic study

Guraya, Sahejmeet; Prayson, Richard A.

doi:10.1016/j.anndiagpath.2016.06.001

Cited by 11 publications

(7 citation statements)

References 22 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Management of schwannomas in head and neck is complete surgical excision, which usually yields excellent results. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

“Ancient” schwannoma of the submandibular gland

Lee

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Schwannomas are solitary neurogenic tumors that arise from cells of the neural sheath. Ancient schwannoma is a relatively rare variant of schwannoma, characterized by increased cellularity and atypia. These cellular changes could be confusing and make the accurate pathologic diagnosis difficult.Patient concerns and diagnoses:A 36-year-old man presented with painless swelling in left submandibular region for more than 2 years. The computed tomography confirmed a well-defined cystic lesion in the left submandibular space, which caused superior and posterior displacement of the left submandibular gland. Surgical excision was performed and the pathology confirmed the diagnosis of ancient schwannoma. To our knowledge, this patient is the second case of primary submandibular ancient schwannoma reported in the literatures.Interventions and outcomes:The patient underwent tumor resection and postoperative recovery was uneventful. There were no nerve deficits after the operation. There was no recurrence within 1 year of follow-up.Lessons:Schwannoma originated from the submandibular gland is extremely rare and only a few cases have been reported. Ancient schwannoma is an even more rare tumor. The increased cellularity and atypia of ancient schwannoma can resemble features of malignancy. Great care must be taken to make differential diagnosis with fibrosarcomas and malignant schwannoma.

show abstract

“…Management of schwannomas in head and neck is complete surgical excision, which usually yields excellent results. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 ] Schwannoma originated from the submandibular gland is extremely rare and only a few cases have been reported. [ 3 ] Ancient schwannoma is an even more rare tumor.…”

Section: Introductionmentioning

confidence: 99%

“Ancient” schwannoma of the submandibular gland

Lee

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…Plexiform neurofibromas are common in patients with NF1 (30–50%), but only in 5–10% of cases does the tumor undergo malignant transformation [ 1 ]. Plexiform neurofibromas of the salivary glands are most commonly reported in the parotid gland [ 5 , 11 , 12 ]. Submandibular salivary gland neurofibromas are rare [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Plexiform neurofibromas, in contrast to other PNST, are diagnosed in early life between the age of 1 and 5 years [ 4 ]. Plexiform neurofibromas of the salivary gland are rare, but when present, they are commonly located in the parotid gland [ 5 ]. They are locally invasive tumors and not prone to metastasizing [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Plexiform Neurofibroma Involving the Lacrimal Gland

Hofsli

Gampenrieder

Heegaard

2017

Case Rep Ophthalmol

View full text Add to dashboard Cite

Background: To present a rare case of a 2-year-old girl with neurofibromatosis type 1 (NF1) who presented with ptosis of the right upper eyelid along with a tumor in the eyelid. Methods: A magnetic resonance imaging scan of the orbit revealed a solid tumor located extraconally at the site of the right lacrimal gland. A transcranial orbitotomy was performed. Results: Histopathological examination demonstrated expanded nerve branches/fascicles cut in various planes in between normal lacrimal gland acini. These findings were consistent with a plexiform neurofibroma presumably deriving from the lacrimal nerve and/or a supraorbital nerve branch. Conclusion: This is the first case of a plexiform neurofibroma involving the lacrimal gland ever described and the tumor shows similarities with neurofibroma in other salivary glands with a high recurrence rate. Plexiform neurofibromas are frequently seen in patients with NF1 and rarely undergo malignant transformation.

show abstract

“…Hypoglossal nerve schwannomas, particularly those originating extracranially and mimicking a submandibular salivary gland tumor, are extremely rare [2,3]. The submandibular gland, one of the major salivary glands, is found beneath the mandible, near the anterior edge of the sternocleidomastoid muscle.…”

Section: Introductionmentioning

confidence: 99%

Unmasking Hypoglossal Nerve Schwannomas Mimicking Submandibular Salivary Gland Tumors: Case Report of a Rare Presentation and Surgical Management

Parisi,

Maniaci,

Broggi

et al. 2023

Surgeries

View full text Add to dashboard Cite

Background: Schwannomas are solitary neurogenic tumors originating from the myelin-producing cells of the neural sheath. Hypoglossal nerve schwannomas are exceedingly rare, particularly those extracranially originating and mimicking a submandibular salivary gland tumor. Methods: We report the case of a 31-year-old female who presented to our ENT department with a painless swelling in her left submandibular region that has persisted for approximately five months. Discussion: Due to the rarity of these tumors and their unique nature, a comprehensive diagnostic workup is imperative for accurate diagnosis. Surgical excision remains the gold standard treatment. Conclusions: Extracranial hypoglossal nerve schwannomas represent a rare clinical entity requiring a thorough diagnostic process for precise identification. The preferred treatment strategy for managing hypoglossal gland schwannomas involves complete tumor excision while preserving the facial nerve.

show abstract

Peripheral nerve sheath tumors arising in salivary glands: A clinicopathologic study

Cited by 11 publications

References 22 publications

“Ancient” schwannoma of the submandibular gland

“Ancient” schwannoma of the submandibular gland

Plexiform Neurofibroma Involving the Lacrimal Gland

Unmasking Hypoglossal Nerve Schwannomas Mimicking Submandibular Salivary Gland Tumors: Case Report of a Rare Presentation and Surgical Management

Contact Info

Product

Resources

About