Peripheral Nerve Sheath Tumor of the Vagus Nerve in a Dog

Yap, F. W.; Pratschke, Kathryn

doi:10.5326/jaaha-ms-6249

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…21,27,28 Rarely reported sites of origin include the lung, spleen, liver, diaphragm, vagus nerve, tongue, omentum, ocular origin, heart, brain, adrenal gland and testis. 22,29–50 Incomplete surgical resection leads to recurrence and metastatic disease is rarely reported. 22,24,39,43,44,46,47,49–52 Stereotactic radiation therapy for canine trigeminal and brachial plexus MPNSTs may prolong survival times when surgical resection is not possible.…”

Section: Discussionmentioning

confidence: 99%

Colonic malignant peripheral nerve sheath tumour in a cat

Boland

Setyo

Sangster

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 14-year-old male neutered domestic mediumhair cat presented with a 4 month history of inappetence and weight loss. Pertinent abnormalities on haematology and biochemistry included a mild microcytic regenerative anaemia (packed cell volume [PCV] 24% [reference interval (RI) 30–45%], mean cell volume 30.8 fl [RI 40–45 fl], absolute reticulocyte count 326.8 × 10 12 ) and increased alkaline phosphatase activity (76 IU/l; RI <50 IU/l). Abdominal ultrasound and CT scan revealed masses in the transverse colon (2.0 cm × 1.2 cm) and right medial liver lobe (5.0 cm diameter). Thoracic radiographs were unremarkable. Right medial liver lobe resection and colectomy were performed. Immunohistochemistry was positive for S-100 protein, vimentin and glial fibrillary acidic protein, very weakly positive for c-kit and negative for muscle-specific actin and CD18, consistent with a colonic malignant peripheral nerve sheath tumour (MPNST) with a hepatic metastasis. Postoperative treatment with metronomic cyclophosphamide was well tolerated. Eighteen months postoperatively the cat re-presented after 3 days of progressive lethargy and inappetence. Haematology revealed a marked non- or pre-regenerative anaemia (PCV 10%). Coagulation times were prolonged (prothrombin time 39 s [RI 15–22 s] and activated partial thromboplastin time >300 s [RI 65–119 s]). Abdominal ultrasound identified multiple renal and hepatic nodules. Euthanasia was performed and post-mortem examination confirmed metastasis of the MPNST. Relevance and novel information This report describes the treatment of a metastatic colonic peripheral nerve sheath tumour in a cat. Feline visceral MPNSTs are rare and little is known about prognosis or optimal treatment.

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Section: Discussionmentioning

confidence: 99%

Colonic malignant peripheral nerve sheath tumour in a cat

Boland

Setyo

Sangster

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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“…21 As the name suggests, an underlying cause cannot be identified, and a diagnosis of idiopathic Horner's syndrome can only be made after excluding all other possible causes. 22 Case reports also documented a neoplastic aetiology of pre-and post-ganglionic Horner's syndrome in dogs with mediastinal lymphoma, 23 peripheral vagus nerve sheath tumours, 24 neuroblastoma 25 and carotid body paraganglioma. 26 Central and pre-ganglionic Horner's syndrome are documented in dogs after traumatic events, specifically during birth, 27 after BP avulsion 28,29 or after a traumatic spinal cord injury.…”

Section: Differential Diagnosismentioning

confidence: 99%

Contralateral Horner's syndrome after ultrasound‐guided right brachial plexus blockade using subscalenic approach in a dog

Prete

Gioeni

Baio

et al. 2023

Vet Record Case Reports

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The objective of this case report is to describe the presentation, development and outcome of left‐sided Horner's syndrome following right brachial plexus blockade using the subscalenic approach in a dog. The patient was admitted for bipedicle advancement flap of the right forelimb. An ultrasound‐guided subscalenic approach for right brachial plexus nerve block was performed using 0.4 mL/kg of ropivacaine 0.375%. After extubation, the dog showed miosis, enophthalmos, palpebral ptosis and protrusion of the third eyelid of the left eye, compatible with left Horner syndrome. The dog did not seem to be uncomfortable, and about 180 minutes after extubation, when sensory function of the right forelimb was partially recovered, signs of left Horner syndrome disappeared. Six hours after extubation, the dog was discharged without any complication. To the authors’ knowledge, there are no reports of contralateral Horner's syndrome after subscalenic brachial plexus blockade in dogs.

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“…In dogs, MPNSTs have been reported in different areas, such as in the cutaneous tissue [ 10 ], liver [ 11 ], diaphragm [ 12 ], vagus nerve [ 13 ], tongue [ 14 ] or intraocular space arising from the ciliary nerve [ 15 ]. However, spinal nerves in the caudal cervical and cranial thoracic region and cranial nerves are most commonly affected [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Metastatic Multifocal Malignant Peripheral Nerve Sheath Tumour in the Cervicothoracic Spinal Cord of a Dog Initially Mimicking Meningomyelitis

Espinosa

Ortega

Pumarola

et al. 2023

Veterinary Sciences

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A nine year old cross-breed dog was presented with a two week history of ambulatory tetraparesis and proprioceptive ataxia affecting all four limbs. Meningomyelitis of Unknown Origin (MUO) was presumptively diagnosed based on the magnetic resonance imaging (MRI) findings and cerebrospinal fluid (CSF) analysis. The dog received a tapering dose of glucocorticoids and cyclosporine, showing significant improvement and the stabilization of the clinical signs for seven months. After this period, the dog showed an acute clinical deterioration and a follow-up MRI revealed new multiple lesions affecting different spinal nerve roots along the cervicothoracic spinal cord. Following euthanasia, a final diagnose of multiple malignant peripheral nerve sheath tumors (MPNSTs) was made based on the histopathological examination. MPNSTs can affect the cranial nerves, spinal nerves or the associated nerve roots at any location and can lead to secondary spinal cord compression. The aim of the present case report is to describe the clinical presentation and atypical MRI findings of a dog with histologically confirmed multiple MPNSTs. According to the reviewed literature, this is the first reported case of simultaneous MPNSTs in the cervicothoracic spinal cord of a dog.

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Peripheral Nerve Sheath Tumor of the Vagus Nerve in a Dog

Cited by 7 publications

References 14 publications

Colonic malignant peripheral nerve sheath tumour in a cat

Colonic malignant peripheral nerve sheath tumour in a cat

Contralateral Horner's syndrome after ultrasound‐guided right brachial plexus blockade using subscalenic approach in a dog

Metastatic Multifocal Malignant Peripheral Nerve Sheath Tumour in the Cervicothoracic Spinal Cord of a Dog Initially Mimicking Meningomyelitis

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