Peripheral nerve repair by means of a flexible biodegradable glass fibre wrap: A comparison with microsurgical epineurial repair

Jeans, L.; Gilchrist, T.; Healy, D. M.

doi:10.1016/j.bjps.2006.06.014

Cited by 56 publications

(56 citation statements)

References 13 publications

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“…Nerve tissue is particularly sensitive to changes in the ionic content of extracellular fluids, and after injury the consequential fluctuations cause Ca excitotoxicity and necrosis in adjacent (uninjured) nerve tissues [15][16][17][18]. This secondary damage occurring at and around the injury site significantly impedes the regeneration and reconnection of nerves, and over distances greater than 5 mm, the reconnection does not occur and functionality is not fully recovered [11,15,[24][25][26][27][28][29]. Standard treatment of nerve injury involves the administration of Methylprednisolone Sodium Succinate (MPSS) to reduce the inflammatory response, which addresses only one of the many impediments encountered by regenerating axons after injury [27,[30][31][32].…”

Section: Introductionmentioning

confidence: 99%

“…This secondary damage occurring at and around the injury site significantly impedes the regeneration and reconnection of nerves, and over distances greater than 5 mm, the reconnection does not occur and functionality is not fully recovered [11,15,[24][25][26][27][28][29]. Standard treatment of nerve injury involves the administration of Methylprednisolone Sodium Succinate (MPSS) to reduce the inflammatory response, which addresses only one of the many impediments encountered by regenerating axons after injury [27,[30][31][32]. Recent studies have shown that bioactive glasses have the potential to encourage nerve regeneration after injury through mechanical guidance and delivery of growth factors [27,28,33].…”

Section: Introductionmentioning

confidence: 99%

“…Standard treatment of nerve injury involves the administration of Methylprednisolone Sodium Succinate (MPSS) to reduce the inflammatory response, which addresses only one of the many impediments encountered by regenerating axons after injury [27,[30][31][32]. Recent studies have shown that bioactive glasses have the potential to encourage nerve regeneration after injury through mechanical guidance and delivery of growth factors [27,28,33]. Therefore, this work proposes the inclusion of Y 2 O 3 and CeO 2 into bioactive glass which may produce ROS scavenging capability similar to that observed in yttria and ceria nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

et al. 2018

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Abstract:The effect on ion release and cytocompatibility of Yttrium (Y) and Cerium (Ce) are investigated when substituted for Sodium (Na) in a 0.52SiO 2 -0.24SrO-0.24-Na 2 O-MO glass series (where MO = Y 2 O 3 or CeO 2 ). Glass leaching was evaluated through pH measurements and Inductive Coupled Plasma-Optical Emission Spectrometry (ICP-OES) analysis where the extract pH increased during incubation (11.2 -12.5). Ion release of Silicon (Si), Na and Strontium (Sr) from the Con glass was at higher than that of glasses containing Y or Ce, and reached a limit after 1 day. Ion release from Y and Ce containing glasses reached a maximum of 1800 µg/mL, 1800 µg/mL, and 10 µg/mL for Si, Na, and Sr, respectively. Release of Y and Ce was below the ICP-OES detection limit <0.1 µg/mL. Cell viability of both L929 fibroblasts and MC3T3 osteoblasts decreased for Con, LY, and LCe extracts; HY extracts did not significantly decrease cell viability while YCe and HCe saw concentrationdependent viability decrease (20%, 33% extract concentrations). Bacterial studies saw Con and LCe eliminating >75% of bacteria at a 9% extract concentration. Antioxidant capacity (mechanism for neuroprotection) was evaluated using the ABTS assay. All glasses had inherent radical oxygen species (ROS) scavenging capability with Con reaching 9.5 mMTE.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

et al. 2018

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“…Research into these materials began with the development of 45S5 Bioglass , discovered in 1969 by Professor Larry Hench, which was found to partially degrade in vivo, allowing for the deposition of a hydroxyl-carbonate apatite (HCA) layer essential to the glass bonding and integration with host tissue when implanted into the body [1]. 45S5 is one of many bioactive glasses that can elicit this response where the key compositional element is 45-60 mol% SiO 2 [2,3] which produces a random network of SiO 2 tetrahedra where some oxygen (O) atoms lack a Si-O BO -Si bonding configuration (bridging oxygen, BO). These non-bridging oxygen (NBO) atoms are instead bound to one Si atom and a modifying element (R) Si-O NBO -R, where the ratio of BO/NBO < 1 has been found necessary to allow glass degradation and bioactivity [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…[2,3] Through compositional modifications, a bioactive glass can be developed that addresses the Ca 2+ accumulation and oxidative stresses that are imposed on nerve tissue after damage; the first is the replacement of Ca 2+ in the glass network with Sr 2+ . Sr 2+ is an ion of similar charge and size to Ca 2+ , has been shown to serve the same network role in bioactive glasses (as a network modifier), encourages bone growth, and is metabolized through the same channels in the body as Ca 2+ [7,31].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Y2O3 and CeO2 doped SiO2-SrO-Na2O glasses

Placek¹,

Keenan²,

Laffir³

et al. 2015

Biomedical Glasses

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Abstract:The structural effects of yttrium (Y) and cerium (Ce) are investigated when substituted for sodium (Na) in a 0.52SiO 2 -0.24SrO-(0.24−x)Na 2 O-xMO (where x = 0.08; MO = Y 2 O 3 and CeO 2 ) glass series. Network connectivity (NC) was calculated assuming both Y and Ce can act as a network modifier (NC = 2.2) or as a network former (NC up to 2.9). Thermal analysis showed an increase in glass transition temperature (Tg) with increasing Y and Ce content, Y causing the greater increase from the control (Con) at 493 ∘ C to 8 mol% Y (HY) at 660 ∘ C. Vickers hardness (HV)was not significantly different between glasses. 29 Si MagicAngle Spinning-Nuclear Magnetic Resonance (MAS-NMR) did not show peak shift with addition of Y, however Ce produced peak broadening and a negative shift in ppm. The addition of 4 mol% Ce in the YCe and LCe glasses shifted the peak from Con at −81.3 ppm to −82.8 ppm and −82.7 ppm respectively; while the HCe glass produced a much broader peak and a shift to −84.8 ppm. High resolution X-ray Photoelectron Spectroscopy for the O 1s spectral line showed the ratio of bridging (BO) to non-bridging oxygens (NBO), BO:NBO, was altered, where Con had a ratio of 0.7, HY decreased to 0.4 and HCe to 0.5.

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Proceedings of a workshop

Bleyer

Morgan

Barr

2006

Cancer

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Background Motor and cognitive function losses resemble handicaps in pediatric posterior fossa tumor survivors. Several factors determine type and extent of impairment. We quantified loss of fine motor function and its association with ataxia and intelligence in patients with and without adjuvant treatment. Procedure Fine motor function, extent of ataxia and cognitive function were assessed in 25 medulloblastoma (MB) and 16 cerebellar pilocytic astrocytoma (PA) patients at least 1 year after completion of therapy. Kinematic parameters (speed, automation, variability, and pressure) of different movement complexity levels were investigated employing a digitizing graphic tablet. Degree of ataxia was quantified using the International Cooperative Ataxia Rating Scale and cognition was determined using the Wechsler Intelligence Scale. Results Kinematic parameters of low and high complexity tasks as well as ataxia of MB patients were strongly impaired. Fine motor impairment was weaker in PA patients, but still evident in the complex task of writing. Ataxia was significantly more pronounced in medulloblastoma patients. Young age and short recovery time correlated significantly with impaired kinematic parameters. Ataxia was strongly associated with inferior fine motor function. Cognition, especially performance IQ, was associated with dysfunctional kinematic parameters. Conclusion The digitizing tablet detected extent of fine motor function loss at varying levels of complexity of pediatric cerebellar tumor survivors. This tool promises to be a potentially effective method for measuring fine motor function in clinical trials and may be helpful in studying mechanisms of neurotoxicity in posterior fossa tumor patients as well as success of rehabilitation. Pediatr Blood Cancer 2009;53:424–431. © 2009 Wiley‐Liss, Inc.

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Peripheral nerve repair by means of a flexible biodegradable glass fibre wrap: A comparison with microsurgical epineurial repair

Cited by 56 publications

References 13 publications

Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

Investigating the Effect of Glass Ion Release on the Cytocompatibility, Antibacterial Eflcacy and Antioxidant Activity of Y2O3 / CeO2 doped SiO2-SrO-Na2O glasses

Characterization of Y2O3 and CeO2 doped SiO2-SrO-Na2O glasses

Proceedings of a workshop

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