Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures

Abstract

The utilization of a planar poly(1,4-butylene succinate) (PBS) scaffold has been demonstrated as an effective approach for preserving nerve continuity and facilitating nerve regeneration. In this study, we assessed the characteristics of a microfibrous tubular scaffold specifically designed and fabricated through electrospinning, utilizing PBS as a biocompatible and biodegradable material. These scaffolds were evaluated as nerve guide conduits in a rat model of sciatic nerve neurotmesis, demonstrating both their biodegradability and efficacy in enhancing the reconstruction process over a long-term period (1-year follow-up). Histological assay and electrophysiological evaluation were performed to compare the long-term outcomes following sutureless repair with the microfibrillar wrap to outcomes obtained using traditional suture repair.

Interaction of graphene and WS2 with neutrophils and mesenchymal stem cells: implications for peripheral nerve regeneration

“…Indeed, once the effect of 2D materials on the players involved in nerve regeneration is unravelled, it would be possible to integrate the materials onto a biopolymer support to realize a planar polymeric structure rolled to form tubular nerve conduits. In the literature there are many examples of 3D tubes prepared from a planar scaffold that can be simply rolled along the lengthwise edge and taped, 122 implanted and wrapped directly around the nerve stumps 123 or prepared using self-rolling films. 124 Similar examples are also between FDA-approved nerve grafts, such as NeuraWrap™ (Integra LifeSciences Co.) that is used by wrapping around the injured nerves, or NeuroMend™ (Collagen Matric, Inc.) that can be unrolled and self-curled to match the dimensions of the injured tissue.…”

Bilateral Scaphoid Fractures: A Systematic Literature Review

“…et al [37] demonstrated improved bone regeneration using an artificial polybutylene succinate scaffold in a rabbit model. This scaffold has already been employed for nerve regeneration in a murine model [38,39]. This application could potentially be considered in the future for cases of bilateral scaphoid fractures in cases not suitable for performing an autologous graft harvesting procedure [40].…”