Peripheral nerve P2 basic protein and the Guillain-Barré syndrome

Luijten, J.A.F.M.; Jong, W. A. C. De; Demel, R.A.; Heijnen, Cobi J.; Ballieux, R. E.

doi:10.1016/0022-510x(84)90009-1

Cited by 9 publications

References 15 publications

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Isolation of P₂ protein–reactive T‐cell lines from human blood

Burns

Krasner

Rostami

et al. 1986

Annals of Neurology

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Human T-cell lines reactive with the peripheral nerve myelin protein, P2 protein, were isolated from the peripheral blood of 4 normal persons and 1 patient with Guillain-Barré syndrome. These predominantly helper phenotype T-cell lines were isolated and maintained in vitro by antigen stimulation followed by culture with interleukin 2. Myelin basic protein-reactive T cells were also isolated in parallel from the same subjects as antigen specificity controls. T cells recognizing myelin basic protein did not respond to P2 protein, nor did P2-reactive cells respond to myelin basic protein. These findings suggest that a potential for autoimmune reactivity with peripheral nervous system myelin antigens may exist for both normal persons and some patients with neurological disease.

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Isolation of P₂ protein–reactive T‐cell lines from human blood

Burns

Krasner

Rostami

et al. 1986

Annals of Neurology

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Manual plasmapheresis in the treatment of guillain‐barré syndrome

Zoysa

Jayaweera

Vaithianathan³

1994

J of Clinical Apheresis

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We report on 41 patients with Guillain-Barré Syndrome (GBS) with disability grade 4 and 5 who were treated with manual plasma exchange (PE). Approximately 20-40 ml/kg body weight of plasma was removed with each manual PE; 63% of patients needed one PE, 24% needed two, 10% needed three, and 2% needed four plasma exchanges. Normal saline, human serum albumin (NSA) and fresh frozen plasma were used in varying proportions as replacement solutions. Ninety-one percent of the patients resumed walking with very little assistance ranging from 4 to 56 days with an average of 25 days from the commencement of the first PE. Manual PE in our series was effective and safe as the reported experience of automated apheresis and less volume of plasma was exchanged in our patients undergoing manual PE when compared to those treated in other studies employing automated PE.

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