Peripheral nerve involvement in lymphoma: the meninges as the crucial barrier between meningoradicular spread and neurolymphomatosis

Grisold, Wolfgang; Klimpfinger, M.; Maehr, Bruno; Pont, J.; Struhal, Walter; Urbanits, Sabine; Vass, Andrea; Vesely, Michael

doi:10.1111/j.1529-8027.2007.00120.x

Cited by 23 publications

(13 citation statements)

References 10 publications

(9 reference statements)

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“…Conversely, when the lymphomatous involvement is limited to the peripheral nerves, CSF may be negative . The identification of the two different patterns, through neurophysiology, neuroimaging, CSF, and histological analysis may be crucial for choosing the appropriate therapy …”

Section: Spinal Nerve Rootsmentioning

confidence: 99%

Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

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The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune‐mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Some clinical findings, such a focal or diffuse involvement, symmetric or asymmetric pattern, presence of pain may point to the correct diagnosis. Besides a thorough medical history and neurological examination, neurophysiological studies, cerebrospinal fluid analysis, nerve biopsy (in selected patients with suspected lymphomatous infiltration) and neuroimaging techniques (magnetic resonance neurography and nerve ultrasound) may be crucial for a proper diagnostic workup.

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Section: Spinal Nerve Rootsmentioning

confidence: 99%

Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

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“…The recognition of this uncommon disease is challenging, but critical to provide adequate management. Exclusive infiltration of peripheral nerves by lymphoma cells is rare with only two patients with NL confined to the peripheral nervous system (PNS) reported in the literature (5, 6). The authors suggested a possible lymphoma-specific interaction between immunologic ligands and endothelial receptors at the blood-nerve barrier as the potential cause.…”

Section: Introductionmentioning

confidence: 99%

Autopsy Proven Peripheral Nervous System Neurolymphomatosis Despite Negative Bilateral Sural Nerve Biopsy

et al. 2013

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Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system lymphoma or systemic lymphoma. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve. Infiltration of brain parenchyma, meninges or Virchow–Robin spaces is characteristic of systemic disease at autopsy. We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy.

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“…Other lymphomas may infiltrate peripheral nerve [53, 54], but infiltration of muscle is occasional [55]. Meningoradicular involvement by lymphoma generally does not concern peripheral nerve nor muscle [56]. …”

Section: Resultsmentioning

confidence: 99%

Clinical Neuropathology practice guide 3-2014: Combined nerve and muscle biopsy in the diagnostic workup of neuropathy â the Bordeaux experience

Vital¹,

Vital²

2014

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Simultaneous combined superficial peroneal nerve and peroneous brevis muscle biopsy, via the same cutaneous incision, allows examination of several tissue specimens and significantly improves the diagnosis of systemic diseases with peripheral nerve involvement. Vasculitides are certainly the most frequently diagnosed on neuro-muscular biopsies, but this procedure is also well advised to asses a diagnosis of sarcoidosis or amyloidosis. More occasionally, combined nerve and muscle biopsy may reveal an unpredicted diagnosis of cholesterol embolism, intra-vascular lymphoma, or enables complementary diagnosis investigations on mitochondrial cytopathy or storage disease.

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Peripheral nerve involvement in lymphoma: the meninges as the crucial barrier between meningoradicular spread and neurolymphomatosis

Cited by 23 publications

References 10 publications

Peripheral nervous system involvement in lymphomas

Peripheral nervous system involvement in lymphomas

Autopsy Proven Peripheral Nervous System Neurolymphomatosis Despite Negative Bilateral Sural Nerve Biopsy

Clinical Neuropathology practice guide 3-2014: Combined nerve and muscle biopsy in the diagnostic workup of neuropathy â the Bordeaux experience

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Peripheral nerve involvement in lymphoma: the meninges as the crucial barrier between meningoradicular spread and neurolymphomatosis

Cited by 23 publications

References 10 publications

Peripheral nervous system involvement in lymphomas

Peripheral nervous system involvement in lymphomas

Autopsy Proven Peripheral Nervous System Neurolymphomatosis Despite Negative Bilateral Sural Nerve Biopsy

Clinical Neuropathology practice guide 3-2014: Combined nerve and muscle biopsy in the diagnostic workup of neuropathy â the Bordeaux experience

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Product

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Clinical Neuropathology practice guide 3-2014: Combined nerve and muscle biopsy in the diagnostic workup of neuropathy â the Bordeaux experience