Peripheral nerve injury elicits microstructural and neurochemical changes in the striatum and substantia nigra of a DYT-TOR1A mouse model with dystonia-like movements

Rauschenberger, Lisa; Krenig, Esther-Marie; Stengl, Alea; Knörr, Susanne; Harder, Tristan H.; Steeg, Felix; Friedrich, M; Grundmann-Hauser, Kathrin; Volkmann, Jens; Ip, Chi Wang

doi:10.1016/j.nbd.2023.106056

Cited by 5 publications

(7 citation statements)

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“…Their high sensitivity has recently been shown to facilitate clinical trials, genotype predictions and continuous monitoring in neurological disorders [24,42,55]. Moreover, our framework may bridge methodological gaps between clinical and experimental neuroscience, which has already widely adapted computer vision for phenotyping animal models of dystonia [15][16][17]. We envisage the proposed tool to strengthen translational and precision medicine approaches in modern neurology.…”

Section: Discussionmentioning

confidence: 99%

“…These kinematic features aimed to quantify clinically relevant observations in dystonia that are commonly noted but seldom quantified in clinical settings, such as movement overflow to other bodyparts as well as action-induced changes of dystonia, both resulting in asymmetrical or abnormal movement trajectories, dystonic tremor[14] and the complexity of dystonia characterised by the involvement of multiple axes in phasic or tonic movements and movement predictability over time. The features were partially harmonised with kinematic features recently reported to be relevant to dystonia phenotype and genetics in rodent models of dystonia [15, 16] as well as the characterisation of brain dynamics more broadly [37, 38]. The derived features primarily included correlations, symmetries, oscillatory and entropy-related characteristics, which are further described below.…”

Section: Methodsmentioning

confidence: 99%

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Quantitative assessment of head movement dynamics in dystonia using visual perceptive deep learning: a multi-centre retrospective longitudinal cohort study

Peach,

Friedrich,

Fronemann

et al. 2023

Preprint

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BackgroundDystonia is a neurological movement disorder characterised by abnormal involuntary movements and postures, particularly affecting the head and neck. However, current clinical assessment methods for dystonia rely on simplified rating scales which lack the ability to capture the intricate spatiotemporal features of dystonic phenomena, hindering clinical management and limiting understanding of the underlying neurobiology. To address this, we developed a visual perceptive deep learning framework that utilizes standard clinical videos to comprehensively evaluate and quantify disease states and the impact of therapeutic interventions, specifically deep brain stimulation. This framework overcomes the limitations of traditional rating scales and offers an efficient and accurate method that is rater-independent for evaluating and monitoring dystonia patients.MethodsTo evaluate the framework, we leveraged semi-standardized clinical video data collected in three retrospective, longitudinal cohort studies across seven academic centres in Germany. We extracted static head angle excursions for clinical validation and derived kinematic variables reflecting naturalistic head dynamics to predict dystonia severity, subtype, and neuromodulation effects. The framework was validated in a fully independent cohort of generalised dystonia patients.FindingsComputer vision-derived measurements of head angle excursions showed a strong correlation with clinically assigned scores, outperforming previous approaches employing specialised camera equipment. Across comparisons, we discovered a consistent set of kinematic features derived from full video assessments, which encoded information relevant to disease severity, subtype, and effects of neural circuit intervention more strongly and independently of static head angle deviations predominantly used for scoring.InterpretationThe proposed visual perceptive machine learning framework reveals kinematic pathosignatures of dystonia which may be utilized to augment clinical management, facilitate scientific translation and inform personalised and precision approaches in Neurology.Research in contextEvidence before this studyClinical assessment of dystonia, a neurological movement disorder, has traditionally relied on rating scales that aim to simplify complex phenomenology into lowerdimensional rating items. However, these score-based assessments have significant clinimetric limitations and do not fully capture the rich spatiotemporal dynamics of dystonic phenomena, which are crucial for clinical judgment and pathophysiological understanding. In contrast, recent investigations in animal models of dystonia have already demonstrated the utility and relevance of quantitative methods for phenotyping, which gradually supersedes previous observer-dependent behavioural analyses. Taken together, this has led to a need for more objective and detailed clinical evaluation methods of dystonia.We performed a PubMed search up to July 2023 combining the terms “dystonia” AND (”deep learning” OR “machine learning” or “computer vision” OR “vision-based” OR “video-based”) AND (”angle” OR “kinematic” OR “rating” OR “scoring” OR “movement analysis”) including abstracts in English or German. The search yielded three studies that validated vision-based frameworks for automating the assessment of cervical dystonia severity compared to clinician-annotated ratings. Two of these studies focused on deriving head angle deviations from specialised camera setups, while the third study utilised computer vision in a retrospective video dataset recorded using conventional equipment. These studies reported fair to moderately strong correlations between vision-based head angle measurements and clinical scores. Additionally, two studies investigated computer vision for assessing head tremor in the context of cervical dystonia: one single case report demonstrated the clinical validity of computer vision-derived head angle and head tremor metrics, while a retrospective cross-sectional study reported moderately strong clinical agreement of computer vision-derived head oscillation metrics across different dystonia subgroups. Two additional studies used computer visionbased kinematics to quantify dystonia-like phenomena in rodent models of monogenetic dystonia, demonstrating utility in both phenotype and genotype predictions.However, most of the clinical studies were limited to static task conditions, where patients attempted to hold a neutral position of the head, thus not providing a naturalistic account of dystonia. Moreover, beyond head angular deviations and oscillation metrics, no study explored a broader kinematic feature space that reflects the true spatiotemporal complexity of dystonic movements. Additionally, the studies assessed patients at single time points without considering different therapy conditions, particularly the effects of deep brain stimulation, which is a highly effective intervention targeting brain circuits. Nor did they compare dystonia sub-types, such as cervical and generalised systonia.Added value of this studyIn this study, we present a comprehensive visual perceptive deep learning framework that addresses the gaps in current dystonia assessments. We use this framework to retrospectively analyse a unique dataset from three multi-centric, studies encompassing video examinations of patients along the dystonic severity continuum, including different deep brain stimulation states. Our framework goes beyond the automation of suboptimal symptom severity assessments by reverse engineering a set of clinically inspired kinematic features. The resulting high dimensional, yet intuitively interpretable kinematic feature space enabled us to explore disease states and effects of brain circuit therapies in a level of detail comparable to experimental neuroscientific investigations. Through a data-driven approach, we have identified a consistent set of only four dynamic parameters that encode dystonia severity, subtype, and the efficacy of brain circuit interventions. Notably, these features are independent of static head angle deviations, which play a central role in dystonia severity scores, pointing to the involvement of partially distinct neurobiological processes not captured by these scores. Our findings align with emerging concepts of symptom-specific brain circuits and findings in rodent models of dystonia, thereby exemplifying the visual perceptive framework’s potential to augment clinical management and bridge translational gaps in movement disorders research. By providing a more comprehensive and precise assessment of the disorder, our study offers valuable insights for improved treatment strategies and further understanding of dystonia’s complex neurobiology.Implications of all the available evidenceThe available evidence collectively underscores the limitations of traditional rating scales in capturing the informative spatiotemporal dynamics of dystonic movements, emphasizing the need for more objective and granular evaluation methods. In line with recent animal studies using computer vision for dystonia quantification, recent clinical studies have shown the potential of computer vision-based frameworks in automating cervical dystonia severity assessment and capturing head tremor metrics. However, their underlying study designs may inadvertently reinforce limitations associated with the clinical scoring process.In this study, we introduce a comprehensive visual perceptive deep learning framework that serves as a powerful platform to augment clinical judgement and generate valuable pathophysiological insights by extracting a set of clinically inspired, interpretable kinematic features. Our findings have implications beyond dystonia, showcasing the utility of visual perceptive frameworks in enhancing clinical management and fostering integration with advanced neuroimaging and neurotechnological methods. This study opens doors for future translational research to explore the broader application of computer vision and deep learning techniques to derive kinematic signatures of movement disorders across species and experimental conditions, promising more precise and personalised assessments that can significantly improve therapeutic strategies and patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Quantitative assessment of head movement dynamics in dystonia using visual perceptive deep learning: a multi-centre retrospective longitudinal cohort study

Peach,

Friedrich,

Fronemann

et al. 2023

Preprint

Self Cite

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“…Their high sensitivity has recently been shown to facilitate clinical trials, genotype predictions and continuous monitoring in neurological disorders 25,38,56 . Moreover, our framework may bridge methodological gaps between clinical and experimental neuroscience, which has already widely adapted computer vision for phenotyping animal models of dystonia [15][16][17] . We envisage the proposed tool to strengthen translational and precision medicine approaches in modern neurology.…”

Section: Discussionmentioning

confidence: 99%

“…These kinematic features aimed to quantify clinically relevant observations in dystonia that are commonly noted but seldom quantified in clinical settings, such as movement overflow to other bodyparts as well as action-induced changes of dystonia, both resulting in asymmetrical or abnormal movement trajectories, dystonic tremor 14 and the complexity of dystonia characterised by the involvement of multiple axes in phasic or tonic movements and movement predictability over time. The features were partially harmonised with kinematic features recently reported to be relevant to dystonia phenotype and genetics in rodent models of dystonia 15 , 16 as well as the characterisation of brain dynamics more broadly 59 , 60 .…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, the original versions of these scales fail to quantify important information regarding abnormal movement trajectories, action-induced changes of dystonia, dystonic overflow (i.e., the spread of dystonic posturing/movement to adjacent body parts), and tremor, which has recently been recognised as affecting a majority of dystonia patients 14 . Yet, emerging evidence from animal models highlights the critical role played by the rich spatiotemporal structure of motor behaviour in understanding the pathocircuitry of dystonia, thereby shaping our approach to investigation and treatment [15][16][17] . The lack of standardised operational and shared measures hampers translational efforts, thus necessitating the development of objective outcome measures 3,18 .…”

mentioning

confidence: 99%

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Head movement dynamics in dystonia: a multi-centre retrospective study using visual perceptive deep learning

Peach,

Friedrich,

Fronemann

et al. 2024

npj Digit. Med.

Self Cite

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Dystonia is a neurological movement disorder characterised by abnormal involuntary movements and postures, particularly affecting the head and neck. However, current clinical assessment methods for dystonia rely on simplified rating scales which lack the ability to capture the intricate spatiotemporal features of dystonic phenomena, hindering clinical management and limiting understanding of the underlying neurobiology. To address this, we developed a visual perceptive deep learning framework that utilizes standard clinical videos to comprehensively evaluate and quantify disease states and the impact of therapeutic interventions, specifically deep brain stimulation. This framework overcomes the limitations of traditional rating scales and offers an efficient and accurate method that is rater-independent for evaluating and monitoring dystonia patients. To evaluate the framework, we leveraged semi-standardized clinical video data collected in three retrospective, longitudinal cohort studies across seven academic centres. We extracted static head angle excursions for clinical validation and derived kinematic variables reflecting naturalistic head dynamics to predict dystonia severity, subtype, and neuromodulation effects. The framework was also applied to a fully independent cohort of generalised dystonia patients for comparison between dystonia sub-types. Computer vision-derived measurements of head angle excursions showed a strong correlation with clinically assigned scores. Across comparisons, we identified consistent kinematic features from full video assessments encoding information critical to disease severity, subtype, and effects of neural circuit interventions, independent of static head angle deviations used in scoring. Our visual perceptive machine learning framework reveals kinematic pathosignatures of dystonia, potentially augmenting clinical management, facilitating scientific translation, and informing personalized precision neurology approaches.

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Gene-environment interaction elicits dystonia-like features and impaired translational regulation in a DYT-TOR1A mouse model

Reinhold,

Knorr,

McFleder

et al. 2024

Neurobiology of Disease

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Peripheral nerve injury elicits microstructural and neurochemical changes in the striatum and substantia nigra of a DYT-TOR1A mouse model with dystonia-like movements

Cited by 5 publications

References 84 publications

Quantitative assessment of head movement dynamics in dystonia using visual perceptive deep learning: a multi-centre retrospective longitudinal cohort study

Quantitative assessment of head movement dynamics in dystonia using visual perceptive deep learning: a multi-centre retrospective longitudinal cohort study

Head movement dynamics in dystonia: a multi-centre retrospective study using visual perceptive deep learning

Gene-environment interaction elicits dystonia-like features and impaired translational regulation in a DYT-TOR1A mouse model

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