Peripheral nerve injuries: Long term follow-up results of rehabilitation

Adıgüzel, Emre; Yaşar, Evren; Tecer, Duygu; Güzelküçük, Ümüt; Kesikburun, Serdar; Özgül, Ahmet

doi:10.3233/bmr-160681

Cited by 20 publications

(25 citation statements)

References 21 publications

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“…In our cases, the most commonly injured nerve was the ulnar nerve (36.67%). This went in accordance with Adiguzel and colleagues [4] who explained the ulnar nerve as the largest unprotected nerve in the body; it is entirely subcutaneous and lacks overlying protective osseous or muscular structures.…”

Section: Discussionsupporting

confidence: 88%

Role of nerve ultrasound versus electrophysiological studies in the evaluation of nerve injuries

El-Fayoumy

Elgendy

Saad

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background: High-resolution ultrasonography (US) is a non-invasive, readily applicable imaging modality capable of depicting real-time static and dynamic information concerning the peripheral nerves and their surrounding tissues. Although electrophysiological studies are the gold standard in the evaluation of nerve injuries, US can be used also to evaluate the morphological changes of nerve injuries. Objectives: To evaluate the role of the high-resolution US in the assessment of nerve injuries and to compare it to the role of electrodiagnostic studies. Subjects and methods: A total of 30 nerves from 22 consecutive patients with clinically definite nerve injury were considered. Two independent and blinded clinicians perform electrodiagnosis and US. The clinical, neurophysiological, and US findings were collected, and the contribution of US was then classified as " contributive" or "non-contributive", according to whether US confirmed the clinical and neurophysiological diagnosis or not. Results: US was "contributive" (confirming the electrophysiological diagnosis) in 66.67% of cases (n = 20), providing information about continuity of the nerve, morphological changes after injury as swelling, scar tissue formation, or neuroma formation with sensitivity of 75% compared to the electrodiagnostic studies and accuracy of 66.67%. Conclusion: Ultrasound can be used, when available, as a complementary tool for electrodiagnostic studies to provide anatomical information about the injured nerves in case of complete axonal lesion.

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Section: Discussionsupporting

confidence: 88%

Role of nerve ultrasound versus electrophysiological studies in the evaluation of nerve injuries

El-Fayoumy

Elgendy

Saad

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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“…In addition, the PNS is also vulnerable to different kinds of traumatic injuries due to the extensive presence of nerves throughout the body [12]. The most common types of traumatic peripheral nerve injuries are penetrating injury, crush injury, traction injury, ischemia, laceration, compression, and thermal injury [13–15]. Trauma due to motor vehicle accidents, penetrating trauma related to violence, falls, and occupational accidents are the most common causes of traumatic injuries to the PNS [16].…”

Section: Introductionmentioning

confidence: 99%

Current and novel polymeric biomaterials for neural tissue engineering

et al. 2018

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The nervous system is a crucial component of the body and damages to this system, either by of injury or disease, can result in serious or potentially lethal consequences. Restoring the damaged nervous system is a great challenge due to the complex physiology system and limited regenerative capacity.Polymers, either synthetic or natural in origin, have been extensively evaluated as a solution for restoring functions in damaged neural tissues. Polymers offer a wide range of versatility, in particular regarding shape and mechanical characteristics, and their biocompatibility is unmatched by other biomaterials, such as metals and ceramics. Several studies have shown that polymers can be shaped into suitable support structures, including nerve conduits, scaffolds, and electrospun matrices, capable of improving the regeneration of damaged neural tissues. In general, natural polymers offer the advantage of better biocompatibility and bioactivity, while synthetic or non-natural polymers have better mechanical properties and structural stability. Often, combinations of the two allow for the development of polymeric conduits able to mimic the native physiological environment of healthy neural tissues and, consequently, regulate cell behaviour and support the regeneration of injured nervous tissues.Currently, most of neural tissue engineering applications are in pre-clinical study, in particular for use in the central nervous system, however collagen polymer conduits aimed at regeneration of peripheral nerves have already been successfully tested in clinical trials.This review highlights different types of natural and synthetic polymers used in neural tissue engineering and their advantages and disadvantages for neural regeneration.

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“…Most common conditions that require replacement of a piece of peripheral nervous tissue are crushing injuries, penetrating injury, traction injury, ischemia, laceration, compression and burns [ 9 , 10 , 11 ]. Trauma due to motor accidents, penetrating trauma related to violence, falls and occupational accidents are the most common causes of traumatic injuries to the peripheral nerves [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Perspectives on 3D Bioprinting of Peripheral Nerve Conduits

Soman¹,

Vijayavenkataraman

2020

IJMS

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The peripheral nervous system controls the functions of sensation, movement and motor coordination of the body. Peripheral nerves can get damaged easily by trauma or neurodegenerative diseases. The injury can cause a devastating effect on the affected individual and his aides. Treatment modalities include anti-inflammatory medications, physiotherapy, surgery, nerve grafting and rehabilitation. 3D bioprinted peripheral nerve conduits serve as nerve grafts to fill the gaps of severed nerve bodies. The application of induced pluripotent stem cells, its derivatives and bioprinting are important techniques that come in handy while making living peripheral nerve conduits. The design of nerve conduits and bioprinting require comprehensive information on neural architecture, type of injury, neural supporting cells, scaffold materials to use, neural growth factors to add and to streamline the mechanical properties of the conduit. This paper gives a perspective on the factors to consider while bioprinting the peripheral nerve conduits.

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Peripheral nerve injuries: Long term follow-up results of rehabilitation

Abstract: Etiology of the patients didn't affect long term results in peripheral nerve injury. The results of this study might help rehabilitation teams to guide their follow-up.

Cited by 20 publications

References 21 publications

Role of nerve ultrasound versus electrophysiological studies in the evaluation of nerve injuries

Role of nerve ultrasound versus electrophysiological studies in the evaluation of nerve injuries

Current and novel polymeric biomaterials for neural tissue engineering

Perspectives on 3D Bioprinting of Peripheral Nerve Conduits

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