Peripheral nerve functions may deteriorate parallel to the progression of microangiopathy in diabetic patients

Ogawa, Kenichi; Sasaki, Hideyuki; Yamasaki, Hiroshi; Okamoto, K.; Matsuno, Shohei; Shono, Toshiyuki; Doi, Takuya; Arimoto, Keiko; Furuta, Hiroto; Nishi, Masahiro; Nakao, Taisei; Nanjo, Kishio

doi:10.1016/j.numecd.2005.06.003

Cited by 19 publications

(18 citation statements)

References 24 publications

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“…It imposes a heavy burden both on a society and patients themselves due to severe complications such as retinopathy, nephropathy as well as other macro-and microangiopathies (5,8,15). Among such complications, peripheral nerve disorders appear at the early stage of DM, and thus its prevalence is high in the patients (4,8,15). Further, somatic nerve disorders, when advanced, lead to sensory paralysis and autonomic disturbance such as orthostatic hypotension, dyshidrosis and digestive disfunctions, which frequently influence prognosis and quality of life of the patients (5,15,24).…”

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confidence: 99%

“…Among such complications, peripheral nerve disorders appear at the early stage of DM, and thus its prevalence is high in the patients (4,8,15). Further, somatic nerve disorders, when advanced, lead to sensory paralysis and autonomic disturbance such as orthostatic hypotension, dyshidrosis and digestive disfunctions, which frequently influence prognosis and quality of life of the patients (5,15,24). To prevent the complications above, it is therefore important to diagnose the diabetic neuropathy at the early stage.…”

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Evaluation of diabetic neuropathy using the tone-entropy analysis, a noninvasive method to estimate the autonomic nervous function

Karino¹,

Nabika²,

Nishiki³

et al. 2009

Biomed. Res.

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It is clinically important to diagnose diabetic neuropathy at the early stage. In this study, the toneentropy analysis of electrocardiogram was applied to diabetic patients to evaluate its usability in the screening of diabetic neuropathy. Consecutive 102 diabetic patients were invited to the study. Electrocardiogram was obtained and analyzed for the tone and the entropy using an original software developed previously. Nerve conduction velocity (NCV) was examined on the median, the posterior tibial and the sural nerves. Patients were divided into quartile subpopulations according to the NCVs in the analysis. Both the tone and the entropy significantly correlated with NCVs, while coefficient of variation in R-R intervals did not show a significant correlation. The correlation was most significant between the entropy and the NCV on the sural nerve. When a multivariate analysis (ordinary regression) was applied to examine independent effects of the factors influencing the NCV on the sural nerve, the entropy was the most potent independent factor (β = 1.14 ± 0.32, P = 0.0004) along with sex (β = 0.43 ± 0.19, P = 0.02) and BMI (β = 0.11 ± 0.05, P = 0.04). The tone-entropy analysis on electrocardiogram may be a promising non-invasive screening method for diabetic neuropathy.

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Evaluation of diabetic neuropathy using the tone-entropy analysis, a noninvasive method to estimate the autonomic nervous function

Karino¹,

Nabika²,

Nishiki³

et al. 2009

Biomed. Res.

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“…The statistically significant associations between the GPx‐1 genotype and DSPN, painful leg cramp, history of MVD and QVP impairment did not disappear, even if it was adjusted for microangiopathies (proteinuria and retinopathy), which are closely related to diabetic neuropathy 20 . The associations between the GPx‐1 genotype and DSPN, painful leg cramp and QVP impairment also kept statistical significance, even after the adjustment for the history of MVD.…”

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confidence: 91%

Pro198Leu missense polymorphism of the glutathione peroxidase 1 gene might be a common genetic predisposition of distal symmetric polyneuropathy and macrovascular disease in Japanese type 2 diabetic patients

Matsuno

Sasaki

Yamasaki

et al. 2011

Journal of Diabetes Investigation

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Aims/Introduction: We have previously reported that the Pro198Leu missense polymorphism in the glutathione peroxidase 1 (GPx‐1) gene was associated with frequent macrovascular disease (MVD). Our goal was to examine whether the GPx‐1 genotype is associated with diabetic neuropathy.Materials and Methods: We determined the GPx‐1 genotype in 173 Japanese type 2 diabetic patients who received medical interviews, physical examinations, nerve conduction studies, quantitative vibratory perception (QVP), head‐up tilt and heart rate variability tests by polymerase chain reaction‐restriction fragment‐length polymorphism. Diabetic sensorimotor distal symmetric polyneuropathy (DSPN) and diabetic autonomic neuropathy (DAN) were evaluated separately. DSPN and DAN were defined by two or more abnormalities of neuropathic leg symptoms, diminished Achilles tendon reflexes or impaired QVP in toes, and two autonomic dysfunctions, respectively. The association of the GPx‐1 genotype with DSPN, DAN, MVD and other clinical manifestations was analyzed.Results: The prevalence of DSPN, impaired QVP and painful leg cramps in patients having a genotype with Pro/Leu at the codon 198 (Pro/Leu type) was significantly higher than those with Pro/Pro type. As a result of multivariate analyses that contained the GPx‐1 genotype as an independent variable, the Pro/Leu type was extracted as a significant risk factor of DSPN, QVP impairment and MVD. The statistical significance did not disappear, even after proteinuria, retinopathy and a history of MVD were introduced as independent variables. In contrast, the GPx‐1 genotype was not associated with DAN.Conclusions: The Pro198Leu missense polymorphism of the GPx‐1 gene might have a common genetic predisposition to DSPN and MVD. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00127.x, 2011)

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“…This figure is estimated to more than double by 2030 1 Advanced DPN causes serious complications, such as diabetic foot ulcers, gangrene, and Charcot joint, all of which worsen the quality of life of diabetic patients 2 .…”

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Ultrasonographic evaluation of peripheral nerves in Diabetic and it`s correlation with nerve conduction

Varadharaju¹

2016

Int.J.Curr.Res.Aca.Rev

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Peripheral nerve functions may deteriorate parallel to the progression of microangiopathy in diabetic patients

Cited by 19 publications

References 24 publications

Evaluation of diabetic neuropathy using the tone-entropy analysis, a noninvasive method to estimate the autonomic nervous function

Evaluation of diabetic neuropathy using the tone-entropy analysis, a noninvasive method to estimate the autonomic nervous function

Pro198Leu missense polymorphism of the glutathione peroxidase 1 gene might be a common genetic predisposition of distal symmetric polyneuropathy and macrovascular disease in Japanese type 2 diabetic patients

Ultrasonographic evaluation of peripheral nerves in Diabetic and it`s correlation with nerve conduction

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