Peripheral nerve abnormality in multiple sclerosis

Pollock, M. R.; Calder, Christopher; Allpress, S.

doi:10.1002/ana.410020107

Cited by 105 publications

(57 citation statements)

References 17 publications

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“…MRI signs of CNS involvement were also detected in patient 2. Optic neuritis, evoked potentials abnormalities, and central MRI abnormalities are common findings in multiple sclerosis, and pathological 14 and electrophysiological 20 abnormalities in the peripheral nerve have been described in patients with otherwise typical multiple sclerosis. The relation between acquired demyelinating peripheral neuropathy and multiple sclerosis is still uncertain.…”

Section: Discussionmentioning

confidence: 99%

Steroid-responsive multifocal demyelinating neuropathy with central involvement

et al. 1999

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We describe 2 patients with associated central and peripheral demyelination. Electrophysiological studies revealed a demyelinating polyneuropathy with sensory and motor conduction blocks. Visual evoked potentials were abnormal. Motor evoked potentials showed abnormal central conduction time in 1 patient. Magnetic resonance imaging revealed regions of abnormal high signal in the spinal cord and brain; sural nerve biopsy disclosed a demyelinating neuropathy. Both patients showed clinical and electrophysiological improvement after steroid therapy. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 262–265, 1999

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Section: Discussionmentioning

confidence: 99%

Steroid-responsive multifocal demyelinating neuropathy with central involvement

et al. 1999

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“…Although MS has classically been considered a CNS disease, many patients have been identified with changes in their peripheral nervous system (Hasson et al, 1958;Pollock et al, 1977;Riggs et al, 1986;Ro et al, 1983;Sarova-Pinhas et al, 1995). Some MS patients exhibit decreased motor conduction (Hopf, 1963) and prolonged proximal peripheral nerve segment conduction time (Mills and Murray, 1986).…”

Section: Mechanisms Of Tmev-infection Induced Painmentioning

confidence: 99%

Analysis of nociception, sex and peripheral nerve innervation in the TMEV animal model of multiple sclerosis

Lynch

Gallus

Ericson

et al. 2008

Pain

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Although pain was previously not considered an important element of multiple sclerosis (MS), recent evidence indicates that over 50% of MS patients suffer from chronic pain. In the present study, we utilized the Theiler's murine encephalomyelitis virus (TMEV) model of MS to examine whether changes in nociception occur during disease progression and to investigate whether sex influences the development of nociception or disease-associated neurological symptoms. Using the rotarod assay, TMEV infected male mice displayed increased neurological deficits when compared to TMEV infected female mice, which mimics what is observed in human MS. While both male and female TMEV infected mice exhibited thermal hyperalgesia and mechanical allodynia, female mice developed mechanical allodynia at a faster rate and displayed significantly more mechanical allodynia than male mice. Since neuropathic symptoms have been described in MS patients, we quantified sensory nerve fibers in the epidermis of TMEV-infected and non-infected mice to determine if there were alterations in epidermal nerve density. There was a significantly higher density of PGP9.5 and CGRP immunoreactive axons in the epidermis of TMEV-infected mice versus controls. Collectively these results indicate that the TMEV model is well suited to study the mechanisms of MS-induced nociception and suggest that alterations in peripheral nerve innervation may contribute to MS pain.

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“…Subsquent to the studies by Hasson et al (1958), several investigations have suggested that the association of MS and peripheral nerve involvement may not be exceptional (Hopf, 1965;Pollock et al 1977;Hopf and Eysholdt ;1978;Weir et al 1980). Hopf (1965) reported that the maximum conduction velocity of the ulnar nerve in 15 randomly selected MS patients was normal in all cases, but the difference in conduction velocity of fastest and slowest neurons was increased in 10 patients.…”

Section: Discussionmentioning

confidence: 98%

“…Hopf (1965) concluded that MS is a generalized disease in the initial stages and in acute exacerbations. Similarly, Pollock et al (1977) studied the sural nerve from 10 MS-patients and 12 age-matched controls, among whom none had clinical evidence of peripheral neuropathy, and only one was severely disabled. They stated that the frequency of abnormal teased fibers was increased in MS.…”

Section: Discussionmentioning

confidence: 99%