Peripheral lymphadenopathy as the initial manifestation of malignant mesothelioma in a child

Gong, Yu-Sen; Yao, Rong; Han, Wen Bo; Zhang, Yingchun

doi:10.1016/j.humpath.2012.09.011

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…20 In the literature, few cases of pediatric MPMs and in young adults have been published; there are a few reports and old articles. [21][22][23][24][25][26] In our study, the average age at diagnosis was 53 years.…”

Section: Discussionmentioning

confidence: 64%

Malignant pleural mesothelioma: Experience of the Medical Oncology Department of Hassan II Hospital in Fez, Morocco

Nouiakh¹,

Benbrahim²,

Oualla³

et al. 2021

JLPRR

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Background: Malignant pleural mesothelioma (MPM) is a primary, rare and aggressive malignant tumor, closely correlated with asbestos exposure. Aim: The objective of this work is to study the main epidemiological, clinical, histological and therapeutic aspects of these tumors and to compare our results with those reported in the literature. Methods: We conducted a retrospective study of 8 cases of MPM collected at the medical oncology department of CHU Hassan II in Fez, for a period of 8 years from January 2011 to January 2019. Results: The mean age at diagnosis was 53 years with an F/H sex ratio of 1.7. Occupational exposure to asbestos was found in only one patient. Pleural effusion syndrome was present in all patients. Biopsy was done under thoracoscopy in 7patients (87.5%). MPM were mostly stage IV (50%). The standard treatment was conventional chemotherapy based on platinum, administered to all patients. After an average number of 4 courses, the objective response rate was 12.5%, and the disease control rate was 50%. Second line chemotherapy consisted of monotherapy with NAVELBINE (67%) or PEMETREXED (33%). After a median follow–up of 17 months, the median of progression–free survival was 5 months, and that of overall survival was 8 months. Conclusion: Based on the results of this study, we conclude that MPM is a very rare tumor in Morocco with poor prognosis. Prognostic factors affecting survival could not be studied due to the low number of patients included in the study, and the lack of data on medical records.

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Section: Discussionmentioning

confidence: 64%

Malignant pleural mesothelioma: Experience of the Medical Oncology Department of Hassan II Hospital in Fez, Morocco

Nouiakh¹,

Benbrahim²,

Oualla³

et al. 2021

JLPRR

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“…12 Cases of mesothelioma associated with asbestos in young adults have, however, been reported in the literature, starting with asbestos exposure between 6 and 11 years of age with a latency period of 11 to 34 years before the development of the disease. 17 In this case, asbestos exposure was not documented in the patient or his direct relatives. Additionally, although pediatric mesotheliomas are more frequently located in the pleura than in the peritoneum, the incidence of peritoneal mesotheliomas are proportionally higher in children than in adults.…”

Section: Discussionmentioning

confidence: 78%

“…Only three pediatric cases have been found 2,6 with a possible association between asbestos exposure and mesothelioma out of 109 cases reported in the literature. 2,12,[14][15][16][17][18] In three other cases, 6 the patients' fathers worked in the construction industry, but asbestos exposure was not confirmed. Moreover, the necessary latency period between asbestos exposure and the development of mesothelioma in adults was absent in these cases.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Malignant Peritoneal Mesothelioma Mimicking an Autoinflammatory Syndrome in a 12-Year-Old Boy

et al. 2021

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A case of a malignant peritoneal mesothelioma mimicking an autoinflammatory syndrome in a 12-year-old boy is reported. The patient initially presented with lymphadenopathy and weight loss but without abdominal pain. Three things confounded the initial diagnosis: a positive test result for a gene related to cryopyrin-associated periodic syndrome, a positive response to the autoinflammatory syndrome treatment, and a lymph node biopsy which showed “hyperplastic mesothelial cells in the lymph sinuses.” His symptoms relapsed several years later, and a peritoneal biopsy confirmed the final diagnosis. Complete morphological, immunohistochemical, and molecular diagnoses are described. A translocation in the TERT gene involving the truncation of the promoter was found in the mesothelioma. The translocation has never been described in mesotheliomas and is of an unknown significance.

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“…Only a few pediatric cases of DMPM are reported in literature. [3][4][5][6][7][8][9][10][11] Its incidence is estimated to be 0.5-1 case/10 million/year. 12 The female-to-male ratio is 2:1.…”

Section: F I G U R Ementioning

confidence: 99%

“…The initial symptoms of DMPM are unspecific, such as abdominal pain, abdominal distension, ascitis and weight loss. Only a few pediatric cases of DMPM are reported in literature 3‐11 . Its incidence is estimated to be 0.5‐1 case/10 million/year 12 .…”

Section: Introductionmentioning

confidence: 99%

Multicystic and diffuse malignant peritoneal mesothelioma in children

Vermersch

Arnaud

Orbach

et al. 2020

Pediatric Blood & Cancer

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Background: Malignant and multicystic peritoneal mesotheliomas are extremely rare tumors in children, developing from mesothelial cells. No specific guidelines are available at this age. Methods: We performed a retrospective analysis of all identified children (< 18-year-old) treated in France from 1987 to 2017 for a diffuse malignant peritoneal mesothelioma (DMPM) or a multicystic peritoneal mesothelioma (MCPM). Results: Fourteen patients (5 males and nine females), aged 2.2 to 17.5 years, were included. The most frequent presenting symptoms were abdominal pain, ascitis, and alteration in the general condition. Eight patients had epithelioid mesothelioma, three had biphasic mesothelioma, and three had MCPM. Eight patients with DMPM diagnosis received cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). Among them, six patients had neoadjuvant systemic chemotherapy, one patient, post-operative chemotherapy, and one patient CRS and HIPEC only. Three patients received only systemic chemotherapy. All patients with MCPM had only surgery. After a median follow-up of seven years (2-15), six patients (6/11; one death) with DMPM and two patients (two/three) with MCPM had a local and distant recurrences. Conclusion: Peritoneal mesothelioma in children is a rare condition with difficult diagnosis and high risk of recurrence. Worldwide interdisciplinary collaboration and networking are mandatory to help diagnosis and provide harmonious treatment guidelines.

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Peripheral lymphadenopathy as the initial manifestation of malignant mesothelioma in a child

Cited by 4 publications

References 18 publications

Malignant pleural mesothelioma: Experience of the Medical Oncology Department of Hassan II Hospital in Fez, Morocco

Malignant pleural mesothelioma: Experience of the Medical Oncology Department of Hassan II Hospital in Fez, Morocco

Metastatic Malignant Peritoneal Mesothelioma Mimicking an Autoinflammatory Syndrome in a 12-Year-Old Boy

Multicystic and diffuse malignant peritoneal mesothelioma in children

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