Peripheral Lung Adenocarcinoma: Correlation of Thin-Section CT Findings with Histologic Prognostic Factors and Survival

Abstract

Thin-section CT findings of peripheral lung adenocarcinomas correlate well with histologic prognostic factors.

Correlation between computed tomography findings and epidermal growth factor receptor and Kras gene mutations in patients with pulmonary adenocarcinoma

“…1), which can be determined readily in the clinical setting. the tumor-length ratio has been reported to be approximately the same value as the tumor area ratio and tumor volume ratio (33). We observed a tendency for the EGFR mutation to occur in tumors with ggo that suggests a close association between g/t ratio and the frequency of EGFR mutation.…”

Correlation in histological subtypes with high resolution computed tomography signatures of early stage lung adenocarcinoma

“…While on CT scans, these indolent and less aggressive tumors of AIS, MIA, and lepidic predominant adenocarcinomas frequently present as pure ground-glass opacity (pGGO) or mixed groundglass opacity (mGGO) (5). Several other studies confirmed a well correlation between CT findings and histologic prognostic factors in lung adenocarcinomas (5)(6)(7). However, when pGGOs are greater than 15 mm in diameter or have high pixel attenuation (>−472 HU), the nodules are more likely to be IA (8).…”

Detection and quantification of the solid component in pulmonary subsolid nodules by semiautomatic segmentation

“…It is recommended to measure the diameter of the solid components and to determine the percentage of solid versus ground-glass components of SSNs. This is important because it has been shown that the greater the extent of the solid component, the more likely the lesion will be an invasive adenocarcinoma with an associated poorer prognosis [8][9][10][11][12][13][14][15]. An SSN with a solid component larger than 5 mm should be considered malignant until proven otherwise, and important decisions to possibly resect a nodule are based on this cut-off.…”

“…Furthermore, different values for the window level and width are used. Aoki et al used electronic calipers to measure the dimensions of the SSN and the solid component on a lung window [8]. The ground glass opacity (GGO) ratio of the SSN is then based on the dimension of the diameter of the solid part divided by the diameter of the whole nodule (Fig.…”